CATH Superfamily 2.30.29.30
Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
".
FunFam 175: switch-associated protein 70 isoform X2
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 4 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
3 | Q6A028 (/IPI) Q9UH65 (/IPI) Q9UH65 (/IPI) |
|
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
|
2 | Q9UH65 (/HDA) Q9UH65 (/HDA) |
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
1 | Q6A028 (/IDA) |
|
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
|
1 | Q6A028 (/IDA) |
There are 16 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Regulation of exit from mitosis GO:0007096
Any process involved in the progression from anaphase/telophase to G1 that is associated with a conversion from high to low mitotic CDK activity.
|
4 | A0A2R8RXH3 (/IMP) Q1LYD9 (/IMP) Q1LYE0 (/IMP) Q1RLS2 (/IMP) |
|
Positive regulation of oligodendrocyte differentiation GO:0048714
Any process that activates or increases the frequency, rate or extent of oligodendrocyte differentiation.
|
4 | A0A2R8RXH3 (/IMP) Q1LYD9 (/IMP) Q1LYE0 (/IMP) Q1RLS2 (/IMP) |
|
Convergent extension GO:0060026
The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis.
|
4 | A0A2R8RXH3 (/IGI) Q1LYD9 (/IGI) Q1LYE0 (/IGI) Q1RLS2 (/IGI) |
|
Convergent extension involved in gastrulation GO:0060027
The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis usually resulting in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm.
|
4 | A0A2R8RXH3 (/IMP) Q1LYD9 (/IMP) Q1LYE0 (/IMP) Q1RLS2 (/IMP) |
|
Convergent extension involved in axis elongation GO:0060028
The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis contributing to the lengthening of the axis of an organism.
|
4 | A0A2R8RXH3 (/IGI) Q1LYD9 (/IGI) Q1LYE0 (/IGI) Q1RLS2 (/IGI) |
|
Positive regulation of cytosolic calcium ion concentration GO:0007204
Any process that increases the concentration of calcium ions in the cytosol.
|
1 | Q6A028 (/IMP) |
|
Regulation of actin polymerization or depolymerization GO:0008064
Any process that modulates the frequency, rate or extent of the assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament.
|
1 | Q6A028 (/IMP) |
|
Somatic cell DNA recombination GO:0016444
Recombination occurring within or between DNA molecules in somatic cells.
|
1 | Q6A028 (/IDA) |
|
Negative regulation of actin filament depolymerization GO:0030835
Any process that stops, prevents, or reduces the frequency, rate or extent of actin depolymerization.
|
1 | Q6A028 (/IDA) |
|
Positive regulation of actin filament bundle assembly GO:0032233
Any process that activates or increases the frequency, rate or extent of the assembly of actin filament bundles.
|
1 | Q6A028 (/IMP) |
|
Regulation of protein localization GO:0032880
Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location.
|
1 | Q6A028 (/IMP) |
|
Negative regulation of cell-cell adhesion mediated by integrin GO:0033633
Any process that stops, prevents, or reduces the frequency, rate, or extent of cell-cell adhesion mediated by integrin.
|
1 | Q6A028 (/IMP) |
|
Isotype switching GO:0045190
The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus.
|
1 | Q6A028 (/IDA) |
|
Actin filament bundle assembly GO:0051017
The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness.
|
1 | Q6A028 (/IDA) |
|
Positive regulation of mast cell chemotaxis GO:0060754
Any process that increases the rate, frequency or extent of mast cell chemotaxis. Mast cell chemotaxis is the movement of a mast cell in response to an external stimulus.
|
1 | Q6A028 (/IMP) |
|
Negative regulation of peptidyl-serine dephosphorylation GO:1902309
Any process that stops, prevents or reduces the frequency, rate or extent of peptidyl-serine dephosphorylation.
|
1 | Q6A028 (/IMP) |
There are 3 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | Q9UH65 (/IDA) Q9UH65 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q6A028 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q6A028 (/ISO) |