The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 169: Fibroblast growth factor receptor substrate 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 10 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
5 O43559 (/IPI) O43559 (/IPI) Q8C180 (/IPI) Q8WU20 (/IPI) Q8WU20 (/IPI)
Fibroblast growth factor receptor binding GO:0005104
Interacting selectively and non-covalently with the fibroblast growth factor receptor (FGFR).
4 O43559 (/IPI) O43559 (/IPI) Q8WU20 (/IPI) Q8WU20 (/IPI)
Transmembrane receptor protein tyrosine kinase adaptor activity GO:0005068
The binding activity of a molecule that brings together a transmembrane receptor protein tyrosine kinase and one or more other molecules, permitting them to function in a coordinated way.
2 Q8WU20 (/TAS) Q8WU20 (/TAS)
Fibroblast growth factor receptor binding GO:0005104
Interacting selectively and non-covalently with the fibroblast growth factor receptor (FGFR).
2 Q8C180 (/ISO) Q91WJ0 (/ISO)
Neurotrophin TRKA receptor binding GO:0005168
Interacting selectively and non-covalently with the neurotrophin TRKA receptor.
2 Q8WU20 (/IPI) Q8WU20 (/IPI)
Phosphatase activator activity GO:0019211
Increases the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule.
2 Q8WU20 (/TAS) Q8WU20 (/TAS)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
2 O43559 (/IPI) O43559 (/IPI)
Transmembrane receptor protein tyrosine kinase adaptor activity GO:0005068
The binding activity of a molecule that brings together a transmembrane receptor protein tyrosine kinase and one or more other molecules, permitting them to function in a coordinated way.
1 Q8C180 (/IDA)
Neurotrophin TRKA receptor binding GO:0005168
Interacting selectively and non-covalently with the neurotrophin TRKA receptor.
1 Q8C180 (/ISO)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 Q91WJ0 (/ISO)

There are 35 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Fibroblast growth factor receptor signaling pathway GO:0008543
The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands.
5 O43559 (/IGI) O43559 (/IGI) Q8C180 (/IGI) Q8WU20 (/IGI) Q8WU20 (/IGI)
MAPK cascade GO:0000165
An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
4 O43559 (/TAS) O43559 (/TAS) Q8WU20 (/TAS) Q8WU20 (/TAS)
Fibroblast growth factor receptor signaling pathway GO:0008543
The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands.
4 O43559 (/TAS) O43559 (/TAS) Q8WU20 (/TAS) Q8WU20 (/TAS)
Activation of MAPKK activity GO:0000186
The initiation of the activity of the inactive enzyme MAP kinase kinase (MAPKK).
2 Q8WU20 (/TAS) Q8WU20 (/TAS)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
2 O43559 (/TAS) O43559 (/TAS)
Transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185
A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses protein tyrosine phosphatase activity, and ending with regulation of a downstream cellular process, e.g. transcription.
2 Q8WU20 (/TAS) Q8WU20 (/TAS)
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
2 Q8WU20 (/TAS) Q8WU20 (/TAS)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
2 Q8WU20 (/TAS) Q8WU20 (/TAS)
Fibroblast growth factor receptor signaling pathway GO:0008543
The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands.
2 Q8C180 (/ISO) Q91WJ0 (/ISO)
Neurotrophin TRK receptor signaling pathway GO:0048011
A series of molecular signals initiated by the binding of a neurotrophin to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription.
2 Q8WU20 (/TAS) Q8WU20 (/TAS)
Positive regulation of protein kinase B signaling GO:0051897
Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
2 Q8WU20 (/TAS) Q8WU20 (/TAS)
Negative regulation of cardiac muscle cell differentiation GO:2000726
Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle cell differentiation.
2 Q8WU20 (/IGI) Q8WU20 (/IGI)
Activation of MAPK activity GO:0000187
The initiation of the activity of the inactive enzyme MAP kinase (MAPK).
1 Q8C180 (/IMP)
Gastrulation with mouth forming second GO:0001702
A gastrulation process in which the initial invagination becomes the anus and the mouth forms second.
1 Q8C180 (/IMP)
Organ induction GO:0001759
The interaction of two or more cells or tissues that causes them to change their fates and specify the development of an organ.
1 Q8C180 (/IMP)
Lens development in camera-type eye GO:0002088
The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus.
1 Q8C180 (/IMP)
Ventricular septum development GO:0003281
The progression of the ventricular septum over time from its formation to the mature structure.
1 Q8C180 (/IMP)
Transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169
A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription.
1 Q8C180 (/IDA)
Neuroblast proliferation GO:0007405
The expansion of a neuroblast population by cell division. A neuroblast is any cell that will divide and give rise to a neuron.
1 Q8C180 (/IGI)
Neuroblast proliferation GO:0007405
The expansion of a neuroblast population by cell division. A neuroblast is any cell that will divide and give rise to a neuron.
1 Q8C180 (/IMP)
Fibroblast growth factor receptor signaling pathway GO:0008543
The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands.
1 Q8C180 (/IMP)
Anterior/posterior axis specification, embryo GO:0008595
The specification of the anterior/posterior axis of the embryo by the products of genes expressed maternally and genes expressed in the zygote.
1 Q8C180 (/IMP)
Forebrain development GO:0030900
The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions).
1 Q8C180 (/IMP)
Regulation of apoptotic process GO:0042981
Any process that modulates the occurrence or rate of cell death by apoptotic process.
1 Q8C180 (/IMP)
Cellular response to fibroblast growth factor stimulus GO:0044344
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an fibroblast growth factor stimulus.
1 D4A244 (/IMP)
Cellular response to fibroblast growth factor stimulus GO:0044344
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an fibroblast growth factor stimulus.
1 Q8C180 (/ISO)
Optic placode formation involved in camera-type eye formation GO:0046619
Establishment and formation of the optic placode, paired ectodermal placodes that become invaginated to form the embryonic lens vesicles.
1 Q8C180 (/IMP)
Regulation of epithelial cell proliferation GO:0050678
Any process that modulates the frequency, rate or extent of epithelial cell proliferation.
1 Q8C180 (/IMP)
Prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis GO:0060527
The branching morphogenesis process in which the prostate epithelial cords branch freely to create the structure of the prostate acini.
1 Q8C180 (/IMP)
Lens fiber cell development GO:0070307
The process whose specific outcome is the progression of a lens fiber cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a lens fiber cell fate. A lens fiber cell is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye.
1 Q8C180 (/IGI)
Lens fiber cell development GO:0070307
The process whose specific outcome is the progression of a lens fiber cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a lens fiber cell fate. A lens fiber cell is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye.
1 Q8C180 (/IMP)
Regulation of ERK1 and ERK2 cascade GO:0070372
Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
1 Q8C180 (/IMP)
Positive regulation of vascular smooth muscle cell proliferation GO:1904707
Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell proliferation.
1 D4A244 (/IMP)
Positive regulation of vascular smooth muscle cell proliferation GO:1904707
Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell proliferation.
1 Q8C180 (/ISO)
Negative regulation of cardiac muscle cell differentiation GO:2000726
Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle cell differentiation.
1 Q8C180 (/ISO)

There are 9 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
5 O43559 (/TAS) O43559 (/TAS) Q52RG8 (/TAS) Q8WU20 (/TAS) Q8WU20 (/TAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
4 D4A244 (/TAS) Q8C180 (/TAS) Q8WU20 (/TAS) Q8WU20 (/TAS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 Q8WU20 (/TAS) Q8WU20 (/TAS)
Cell-cell adherens junction GO:0005913
An adherens junction which connects a cell to another cell.
2 Q8WU20 (/IDA) Q8WU20 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 Q8WU20 (/TAS) Q8WU20 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q8C180 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q8C180 (/IDA)
Cell-cell junction GO:0005911
A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals.
1 Q8C180 (/IDA)
Cell-cell adherens junction GO:0005913
An adherens junction which connects a cell to another cell.
1 Q8C180 (/ISO)