The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 14: Homer homolog 1 (Drosophila)

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 33 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
16 M9PB54 (/IPI) M9PEX1 (/IPI) O88801 (/IPI) O96607 (/IPI) Q0E8S7 (/IPI) Q86YM7 (/IPI) Q86YM7 (/IPI) Q86YM7 (/IPI) Q99JP6 (/IPI) Q9NSB8 (/IPI)
(6 more)
Signaling adaptor activity GO:0035591
The binding activity of a molecule that brings together two or more molecules in a signaling pathway, permitting those molecules to function in a coordinated way. Adaptor molecules themselves do not have catalytic activity.
3 Q86YM7 (/IC) Q86YM7 (/IC) Q86YM7 (/IC)
Ion channel binding GO:0044325
Interacting selectively and non-covalently with one or more specific sites on an ion channel, a protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.
3 Q86YM7 (/IPI) Q86YM7 (/IPI) Q86YM7 (/IPI)
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
2 Q0VCH1 (/ISS) Q0VCH1 (/ISS)
GKAP/Homer scaffold activity GO:0030160
Functions as a physical support bridging the N-methyl-D-aspartate receptor-PSD-95-GKAP complex and the mGluR-Homer complex, which are involved in receptor signaling in synapses.
2 Q0VCH1 (/ISS) Q0VCH1 (/ISS)
G protein-coupled glutamate receptor binding GO:0035256
Interacting selectively and non-covalently with a G protein-coupled glutamate receptor (a metabotropic glutamate receptor).
2 O88801 (/IPI) Q9Z214 (/IPI)
G protein-coupled glutamate receptor binding GO:0035256
Interacting selectively and non-covalently with a G protein-coupled glutamate receptor (a metabotropic glutamate receptor).
2 Q9QWW1 (/ISO) Q9Z2Y3 (/ISO)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
2 Q99JP6 (/ISO) Q9Z2Y3 (/ISO)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
2 O88801 (/IPI) Q9Z214 (/IPI)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
2 Q9QWW1 (/ISO) Q9Z2Y3 (/ISO)
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
1 Q9QWW1 (/IDA)
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
1 Q9Z214 (/IDA)
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
1 Q9Z2Y3 (/ISO)
Protein C-terminus binding GO:0008022
Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
1 Q99JP6 (/IPI)
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
1 O88801 (/IMP)
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
1 Q99JP6 (/IPI)
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
1 Q9QWW1 (/ISO)
GKAP/Homer scaffold activity GO:0030160
Functions as a physical support bridging the N-methyl-D-aspartate receptor-PSD-95-GKAP complex and the mGluR-Homer complex, which are involved in receptor signaling in synapses.
1 Q9QWW1 (/IDA)
Type 5 metabotropic glutamate receptor binding GO:0031802
Interacting selectively and non-covalently with a type 5 metabotropic glutamate receptor.
1 Q9Z214 (/IPI)
Type 5 metabotropic glutamate receptor binding GO:0031802
Interacting selectively and non-covalently with a type 5 metabotropic glutamate receptor.
1 Q9Z2Y3 (/ISO)
Glutamate receptor binding GO:0035254
Interacting selectively and non-covalently with a glutamate receptor.
1 O88801 (/IPI)
Glutamate receptor binding GO:0035254
Interacting selectively and non-covalently with a glutamate receptor.
1 Q9QWW1 (/ISO)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 Q9NSC5 (/IPI)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 O88801 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 Q9QWW1 (/ISO)
Ion channel binding GO:0044325
Interacting selectively and non-covalently with one or more specific sites on an ion channel, a protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.
1 Q9Z2Y3 (/ISO)
Molecular adaptor activity GO:0060090
The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way.
1 Q9Z214 (/IPI)
Molecular adaptor activity GO:0060090
The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way.
1 Q9Z2Y3 (/ISO)
Scaffold protein binding GO:0097110
Interacting selectively and non-covalently with a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes.
1 Q9Z214 (/IPI)
Scaffold protein binding GO:0097110
Interacting selectively and non-covalently with a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes.
1 Q9Z2Y3 (/ISO)
Structural constituent of postsynapse GO:0099186
The action of a molecule that contributes to the structural integrity of a postsynapse.
1 Q9Z214 (/IDA)
Structural constituent of postsynapse GO:0099186
The action of a molecule that contributes to the structural integrity of a postsynapse.
1 Q9Z214 (/IMP)
Structural constituent of postsynapse GO:0099186
The action of a molecule that contributes to the structural integrity of a postsynapse.
1 Q9Z2Y3 (/ISO)

There are 52 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
G protein-coupled glutamate receptor signaling pathway GO:0007216
A series of molecular signals initiated by glutamate binding to a glutamate receptor on the surface of the target cell, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. Ends with regulation of a downstream cellular process, e.g. transcription.
6 Q99JP6 (/TAS) Q9NSB8 (/TAS) Q9NSB8 (/TAS) Q9NSC5 (/TAS) Q9QWW1 (/TAS) Q9Z2Y3 (/TAS)
Regulation of synaptic transmission, glutamatergic GO:0051966
Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate.
6 Q2KJ56 (/ISS) Q86YM7 (/ISS) Q86YM7 (/ISS) Q86YM7 (/ISS) Q9Z214 (/ISS) Q9Z2Y3 (/ISS)
Regulation of dendritic spine maintenance GO:1902950
Any process that modulates the frequency, rate or extent of dendritic spine maintenance.
6 Q2KJ56 (/ISS) Q86YM7 (/ISS) Q86YM7 (/ISS) Q86YM7 (/ISS) Q9Z214 (/ISS) Q9Z2Y3 (/ISS)
Adult behavior GO:0030534
Behavior in a fully developed and mature organism.
5 M9PB54 (/IMP) M9PEX1 (/IMP) O96607 (/IMP) Q0E8S7 (/IMP) Q9VM94 (/IMP)
Regulation of locomotion GO:0040012
Any process that modulates the frequency, rate or extent of locomotion of a cell or organism.
5 M9PB54 (/IMP) M9PEX1 (/IMP) O96607 (/IMP) Q0E8S7 (/IMP) Q9VM94 (/IMP)
Response to ethanol GO:0045471
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.
5 M9PB54 (/IDA) M9PEX1 (/IDA) O96607 (/IDA) Q0E8S7 (/IDA) Q9VM94 (/IDA)
Positive regulation of circadian sleep/wake cycle, sleep GO:0045938
Any process that activates or increases the duration or quality of sleep, a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals.
5 M9PB54 (/IMP) M9PEX1 (/IMP) O96607 (/IMP) Q0E8S7 (/IMP) Q9VM94 (/IMP)
Behavioral response to ethanol GO:0048149
Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus.
5 M9PB54 (/IMP) M9PEX1 (/IMP) O96607 (/IMP) Q0E8S7 (/IMP) Q9VM94 (/IMP)
Protein tetramerization GO:0051262
The formation of a protein tetramer, a macromolecular structure consisting of four noncovalently associated identical or nonidentical subunits.
5 Q2KJ56 (/ISS) Q86YM7 (/ISS) Q86YM7 (/ISS) Q86YM7 (/ISS) Q9Z2Y3 (/ISS)
Cellular calcium ion homeostasis GO:0006874
Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell.
4 A0A0R4INT7 (/IGI) B8JIC5 (/IGI) Q6DEI7 (/IGI) Q6DGN5 (/IGI)
Negative regulation of interleukin-2 production GO:0032703
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-2 production.
4 O88801 (/ISS) Q99JP6 (/ISS) Q9QWW1 (/ISS) Q9Z2X5 (/ISS)
Muscle structure development GO:0061061
The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms.
4 A0A0R4INT7 (/IMP) B8JIC5 (/IMP) Q6DEI7 (/IMP) Q6DGN5 (/IMP)
Negative regulation of calcineurin-NFAT signaling cascade GO:0070885
Any process that stops, prevents, or reduces the frequency, rate or extent of the calcineurin-NFAT signaling cascade.
4 O88801 (/ISS) Q99JP6 (/ISS) Q9QWW1 (/ISS) Q9Z2X5 (/ISS)
Phospholipase C-activating G protein-coupled glutamate receptor signaling pathway GO:0007206
The series of molecular signals generated as a consequence of a G protein-coupled glutamate receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent release of inositol trisphosphate (IP3) and diacylglycerol (DAG).
3 Q86YM7 (/TAS) Q86YM7 (/TAS) Q86YM7 (/TAS)
Chemical synaptic transmission GO:0007268
The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
3 Q86YM7 (/TAS) Q86YM7 (/TAS) Q86YM7 (/TAS)
Sensory perception of sound GO:0007605
The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound.
3 Q9NSB8 (/IMP) Q9NSB8 (/IMP) Q9QWW1 (/IMP)
Positive regulation of signal transduction GO:0009967
Any process that activates or increases the frequency, rate or extent of signal transduction.
3 Q86YM7 (/IC) Q86YM7 (/IC) Q86YM7 (/IC)
Negative regulation of interleukin-2 production GO:0032703
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-2 production.
3 Q9NSB8 (/IMP) Q9NSB8 (/IMP) Q9NSC5 (/IMP)
Response to calcium ion GO:0051592
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
3 Q86YM7 (/IDA) Q86YM7 (/IDA) Q86YM7 (/IDA)
Negative regulation of calcineurin-NFAT signaling cascade GO:0070885
Any process that stops, prevents, or reduces the frequency, rate or extent of the calcineurin-NFAT signaling cascade.
3 Q9NSB8 (/IMP) Q9NSB8 (/IMP) Q9NSC5 (/IMP)
Regulation of store-operated calcium entry GO:2001256
Any process that modulates the frequency, rate or extent of store-operated calcium entry.
3 Q86YM7 (/TAS) Q86YM7 (/TAS) Q86YM7 (/TAS)
Regulation of cation channel activity GO:2001257
Any process that modulates the frequency, rate or extent of cation channel activity.
3 Q86YM7 (/TAS) Q86YM7 (/TAS) Q86YM7 (/TAS)
Olfactory nerve formation GO:0021628
The process that gives rise to the olfactory nerve. This process pertains to the initial formation of a structure from unspecified parts. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem.
2 B0JZL8 (/IMP) Q502P2 (/IMP)
Negative regulation of interleukin-2 production GO:0032703
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-2 production.
2 Q99JP6 (/ISO) Q9QWW1 (/ISO)
Behavioral response to cocaine GO:0048148
Any process that results in a change in the behavior of an organism as a result of a cocaine stimulus.
2 Q9QWW1 (/IMP) Q9Z2Y3 (/IMP)
Chemical homeostasis within a tissue GO:0048875
Any process involved in the maintenance of the internal steady state of the amount of a chemical at the level of the tissue.
2 Q9QWW1 (/IMP) Q9Z2Y3 (/IMP)
Negative regulation of calcineurin-NFAT signaling cascade GO:0070885
Any process that stops, prevents, or reduces the frequency, rate or extent of the calcineurin-NFAT signaling cascade.
2 Q99JP6 (/ISO) Q9QWW1 (/ISO)
Olfactory placode morphogenesis GO:0071699
The process in which the anatomical structures of the olfactory placode are generated and organized. The olfactory placode is a thickening of the neural ectoderm in the head region of the vertebrate embryo which develops into the olfactory region of the nasal cavity.
2 B0JZL8 (/IMP) Q502P2 (/IMP)
Regulation of postsynaptic neurotransmitter receptor activity GO:0098962
Any process that modulates the frequency, rate or extent of neurotransmitter receptor activity involved in synaptic transmission. Modulation may be via an effect on ligand affinity, or effector funtion such as ion selectivity or pore opening/closing in ionotropic receptors.
2 Q99JP6 (/IDA) Q9Z2Y3 (/IDA)
Regulation of postsynaptic neurotransmitter receptor activity GO:0098962
Any process that modulates the frequency, rate or extent of neurotransmitter receptor activity involved in synaptic transmission. Modulation may be via an effect on ligand affinity, or effector funtion such as ion selectivity or pore opening/closing in ionotropic receptors.
2 Q99JP6 (/IMP) Q9Z2Y3 (/IMP)
Skeletal muscle contraction GO:0003009
A process in which force is generated within skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and in most cases it is under voluntary control.
1 Q9Z2Y3 (/IMP)
Protein targeting GO:0006605
The process of targeting specific proteins to particular regions of the cell, typically membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif.
1 Q9NSC5 (/TAS)
G protein-coupled glutamate receptor signaling pathway GO:0007216
A series of molecular signals initiated by glutamate binding to a glutamate receptor on the surface of the target cell, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. Ends with regulation of a downstream cellular process, e.g. transcription.
1 Q9Z214 (/IDA)
G protein-coupled glutamate receptor signaling pathway GO:0007216
A series of molecular signals initiated by glutamate binding to a glutamate receptor on the surface of the target cell, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. Ends with regulation of a downstream cellular process, e.g. transcription.
1 Q9Z2Y3 (/ISO)
Sensory perception of sound GO:0007605
The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound.
1 Q9QWW1 (/ISO)
Sensory perception of sound GO:0007605
The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound.
1 O88801 (/ISS)
Circadian rhythm GO:0007623
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
1 Q9Z214 (/IEP)
Regulation of G protein-coupled receptor signaling pathway GO:0008277
Any process that modulates the frequency, rate or extent of G protein-coupled receptor signaling pathway.
1 Q9QWW1 (/IDA)
Response to nicotine GO:0035094
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus.
1 Q9Z214 (/IEP)
Protein localization to synapse GO:0035418
Any process in which a protein is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.
1 Q9Z214 (/IDA)
Protein localization to synapse GO:0035418
Any process in which a protein is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.
1 Q9Z2Y3 (/ISO)
Calcium-mediated signaling using intracellular calcium source GO:0035584
A series of molecular signals in which a cell uses calcium ions released from an intracellular store to convert a signal into a response.
1 Q9QWW1 (/IMP)
Response to cocaine GO:0042220
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant.
1 Q9Z214 (/IEP)
Skeletal muscle fiber development GO:0048741
The process whose specific outcome is the progression of the skeletal muscle fiber over time, from its formation to the mature structure. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast.
1 Q9Z2Y3 (/IMP)
Protein tetramerization GO:0051262
The formation of a protein tetramer, a macromolecular structure consisting of four noncovalently associated identical or nonidentical subunits.
1 Q9Z2Y3 (/ISO)
Response to calcium ion GO:0051592
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
1 Q9Z2Y3 (/ISO)
Positive regulation of calcium ion transport GO:0051928
Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q9Z2Y3 (/IMP)
Regulation of synaptic transmission, glutamatergic GO:0051966
Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate.
1 Q9Z2Y3 (/ISO)
Regulation of calcium ion import GO:0090279
Any process that modulates the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle.
1 Q9Z2Y3 (/IMP)
Regulation of dendritic spine maintenance GO:1902950
Any process that modulates the frequency, rate or extent of dendritic spine maintenance.
1 Q9Z2Y3 (/ISO)
Regulation of store-operated calcium entry GO:2001256
Any process that modulates the frequency, rate or extent of store-operated calcium entry.
1 Q9Z2Y3 (/IMP)
Regulation of cation channel activity GO:2001257
Any process that modulates the frequency, rate or extent of cation channel activity.
1 Q9Z2Y3 (/IMP)

There are 37 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
7 Q86YM7 (/TAS) Q86YM7 (/TAS) Q86YM7 (/TAS) Q9NSB8 (/TAS) Q9NSB8 (/TAS) Q9NSC5 (/TAS) Q9Z214 (/TAS)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
7 M9PB54 (/IDA) M9PEX1 (/IDA) O88801 (/IDA) O96607 (/IDA) Q0E8S7 (/IDA) Q9VM94 (/IDA) Q9Z214 (/IDA)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
5 M9PB54 (/IDA) M9PEX1 (/IDA) O96607 (/IDA) Q0E8S7 (/IDA) Q9VM94 (/IDA)
Neuron spine GO:0044309
A small membranous protrusion, often ending in a bulbous head and attached to the neuron by a narrow stalk or neck.
5 Q2KJ56 (/ISS) Q86YM7 (/ISS) Q86YM7 (/ISS) Q86YM7 (/ISS) Q9Z2Y3 (/ISS)
Postsynaptic density GO:0014069
An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
4 Q99JP6 (/IDA) Q9QWW1 (/IDA) Q9Z214 (/IDA) Q9Z2Y3 (/IDA)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
4 Q99JP6 (/IDA) Q9QWW1 (/IDA) Q9Z214 (/IDA) Q9Z2Y3 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 Q9NSB8 (/IDA) Q9NSB8 (/IDA) Q9Z2Y3 (/IDA)
Stereocilium tip GO:0032426
A distinct compartment at the tip of a stereocilium, distal to the site of attachment to the apical cell surface. It consists of a dense matrix bridging the barbed ends of the stereocilium actin filaments with the overlying plasma membrane, is dynamic compared to the shaft, and is required for stereocilium elongation.
3 O88801 (/ISS) Q9NSB8 (/ISS) Q9NSB8 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q0VCH1 (/ISS) Q0VCH1 (/ISS)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
2 Q9QWW1 (/ISO) Q9Z2Y3 (/ISO)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
2 Q9Z214 (/IDA) Q9Z2Y3 (/IDA)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
2 O88801 (/IDA) Q9Z214 (/IDA)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
2 Q9QWW1 (/ISO) Q9Z2Y3 (/ISO)
Apical part of cell GO:0045177
The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.
2 Q9QWW1 (/IDA) Q9Z2Y3 (/IDA)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
2 Q9Z214 (/IMP) Q9Z2Y3 (/IMP)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q9QWW1 (/IMP)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q9QWW1 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q99JP6 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q9Z2Y3 (/IDA)
Postsynaptic density GO:0014069
An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
1 Q9Z2Y3 (/IMP)
Postsynaptic density GO:0014069
An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
1 Q9Z2Y3 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q9Z2Y3 (/IDA)
Z disc GO:0030018
Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.
1 Q9Z2Y3 (/IDA)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
1 Q9Z2Y3 (/IDA)
Stereocilium tip GO:0032426
A distinct compartment at the tip of a stereocilium, distal to the site of attachment to the apical cell surface. It consists of a dense matrix bridging the barbed ends of the stereocilium actin filaments with the overlying plasma membrane, is dynamic compared to the shaft, and is required for stereocilium elongation.
1 Q9QWW1 (/IDA)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
1 Q9Z2Y3 (/IMP)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
1 Q9Z2Y3 (/ISO)
Costamere GO:0043034
Regular periodic sub membranous arrays of vinculin in skeletal and cardiac muscle cells, these arrays link Z-discs to the sarcolemma and are associated with links to extracellular matrix.
1 Q9Z2Y3 (/IDA)
Dendritic shaft GO:0043198
Cylindric portion of the dendrite, directly stemming from the perikaryon, and carrying the dendritic spines.
1 Q9Z214 (/IDA)
Dendritic shaft GO:0043198
Cylindric portion of the dendrite, directly stemming from the perikaryon, and carrying the dendritic spines.
1 Q9Z2Y3 (/ISO)
Neuron spine GO:0044309
A small membranous protrusion, often ending in a bulbous head and attached to the neuron by a narrow stalk or neck.
1 Q9Z2Y3 (/ISO)
Basal part of cell GO:0045178
The region of a cell situated near the base. For example, in a polarized epithelial cell, the basal surface rests on the basal lamina that separates the epithelium from other tissue.
1 Q99JP6 (/IDA)
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
1 Q9Z214 (/IDA)
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
1 Q9Z2Y3 (/ISO)
Postsynapse GO:0098794
The part of a synapse that is part of the post-synaptic cell.
1 Q9Z2Y3 (/IDA)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
1 Q9Z2Y3 (/ISO)
Postsynaptic cytosol GO:0099524
The region of the cytosol consisting of all cytosol that is part of the postsynapse.
1 Q9Z2Y3 (/IDA)