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CATH Superfamily 1.20.58.60

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 244: Spectrin beta chain

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 11 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
 3 E9PX29 (/IPI) Q8VIE5 (/IPI) Q9H254 (/IPI)
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
 2 E9PX29 (/IDA) Q8VIE5 (/IDA)
Phosphatase binding GO:0019902
Interacting selectively and non-covalently with any phosphatase.
 2 E9PX29 (/ISO) Q8VIE5 (/ISO)
Ankyrin binding GO:0030506
Interacting selectively and non-covalently with ankyrin, a 200 kDa cytoskeletal protein that attaches other cytoskeletal proteins to integral membrane proteins.
 2 E9PX29 (/ISO) Q8VIE5 (/ISO)
Spectrin binding GO:0030507
Interacting selectively and non-covalently with spectrin, a protein that is the major constituent of the erythrocyte cytoskeletal network. It associates with band 4.1 (see band protein) and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. It is composed of nonhomologous chains, alpha and beta, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers.
 2 E9PX29 (/IDA) Q8VIE5 (/IDA)
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
 1 Q9H254 (/ISS)
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
 1 Q9H254 (/TAS)
Structural constituent of cytoskeleton GO:0005200
The action of a molecule that contributes to the structural integrity of a cytoskeletal structure.
 1 Q9H254 (/TAS)
Phosphatase binding GO:0019902
Interacting selectively and non-covalently with any phosphatase.
 1 Q9H254 (/IPI)
Ankyrin binding GO:0030506
Interacting selectively and non-covalently with ankyrin, a 200 kDa cytoskeletal protein that attaches other cytoskeletal proteins to integral membrane proteins.
 1 Q9H254 (/IDA)
Spectrin binding GO:0030507
Interacting selectively and non-covalently with spectrin, a protein that is the major constituent of the erythrocyte cytoskeletal network. It associates with band 4.1 (see band protein) and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. It is composed of nonhomologous chains, alpha and beta, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers.
 1 Q9H254 (/ISS)

There are 31 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of sodium ion transport GO:0002028
Any process that modulates the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
 2 E9PX29 (/IMP) Q8VIE5 (/IMP)
Axonogenesis GO:0007409
De novo generation of a long process of a neuron, including the terminal branched region. Refers to the morphogenesis or creation of shape or form of the developing axon, which carries efferent (outgoing) action potentials from the cell body towards target cells.
 2 E9PX29 (/IMP) Q8VIE5 (/IMP)
Sensory perception of sound GO:0007605
The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound.
 2 E9PX29 (/IMP) Q8VIE5 (/IMP)
Adult walking behavior GO:0007628
The behavior of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg.
 2 E9PX29 (/IMP) Q8VIE5 (/IMP)
Fertilization GO:0009566
The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy).
 2 E9PX29 (/IMP) Q8VIE5 (/IMP)
Negative regulation of heart rate GO:0010459
Any process that stops, prevents or reduces the frequency or rate of heart contraction.
 2 E9PX29 (/IMP) Q8VIE5 (/IMP)
Transmission of nerve impulse GO:0019226
The neurological system process in which a signal is transmitted through the nervous system by a combination of action potential propagation and synaptic transmission.
 2 E9PX29 (/IMP) Q8VIE5 (/IMP)
Central nervous system projection neuron axonogenesis GO:0021952
Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells in a different central nervous system region.
 2 E9PX29 (/IMP) Q8VIE5 (/IMP)
Reproductive process GO:0022414
A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents.
 2 E9PX29 (/IMP) Q8VIE5 (/IMP)
Adult behavior GO:0030534
Behavior in a fully developed and mature organism.
 2 E9PX29 (/IMP) Q8VIE5 (/IMP)
Regulation of peptidyl-serine phosphorylation GO:0033135
Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-serine.
 2 E9PX29 (/IDA) Q8VIE5 (/IDA)
Cellular protein localization GO:0034613
Any process in which a protein is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell.
 2 E9PX29 (/IMP) Q8VIE5 (/IMP)
Positive regulation of multicellular organism growth GO:0040018
Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size.
 2 E9PX29 (/IMP) Q8VIE5 (/IMP)
Clustering of voltage-gated sodium channels GO:0045162
The process in which voltage-gated sodium channels become localized together in high densities. In animals, nodes of Ranvier differ dramatically from internodal axonal regions in very high densities of voltage-dependent sodium (Nav) channels responsible for the rapid, inward ionic currents that produce membrane depolarization.
 2 E9PX29 (/IMP) Q8VIE5 (/IMP)
Cardiac conduction GO:0061337
Transfer of an organized electrical impulse across the heart to coordinate the contraction of cardiac muscles. The process begins with generation of an action potential (in the sinoatrial node (SA) in humans) and ends with a change in the rate, frequency, or extent of the contraction of the heart muscles.
 2 E9PX29 (/IMP) Q8VIE5 (/IMP)
MAPK cascade GO:0000165
An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
 1 Q9H254 (/TAS)
Regulation of sodium ion transport GO:0002028
Any process that modulates the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
 1 Q9H254 (/ISS)
Endoplasmic reticulum to Golgi vesicle-mediated transport GO:0006888
The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi.
 1 Q9H254 (/TAS)
Cytoskeletal anchoring at plasma membrane GO:0007016
A cytoskeleton organization process that directly or indirectly links cytoskeletal filaments to the plasma membrane.
 1 Q9H254 (/TAS)
Axonogenesis GO:0007409
De novo generation of a long process of a neuron, including the terminal branched region. Refers to the morphogenesis or creation of shape or form of the developing axon, which carries efferent (outgoing) action potentials from the cell body towards target cells.
 1 Q9H254 (/ISS)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
 1 Q9H254 (/TAS)
Sensory perception of sound GO:0007605
The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound.
 1 Q9H254 (/ISS)
Adult walking behavior GO:0007628
The behavior of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg.
 1 Q9H254 (/ISS)
Negative regulation of heart rate GO:0010459
Any process that stops, prevents or reduces the frequency or rate of heart contraction.
 1 Q9H254 (/ISS)
Vesicle-mediated transport GO:0016192
A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.
 1 Q9H254 (/TAS)
Transmission of nerve impulse GO:0019226
The neurological system process in which a signal is transmitted through the nervous system by a combination of action potential propagation and synaptic transmission.
 1 Q9H254 (/ISS)
Central nervous system projection neuron axonogenesis GO:0021952
Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells in a different central nervous system region.
 1 Q9H254 (/ISS)
Regulation of peptidyl-serine phosphorylation GO:0033135
Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-serine.
 1 Q9H254 (/ISS)
Clustering of voltage-gated sodium channels GO:0045162
The process in which voltage-gated sodium channels become localized together in high densities. In animals, nodes of Ranvier differ dramatically from internodal axonal regions in very high densities of voltage-dependent sodium (Nav) channels responsible for the rapid, inward ionic currents that produce membrane depolarization.
 1 Q9H254 (/ISS)
Cardiac conduction GO:0061337
Transfer of an organized electrical impulse across the heart to coordinate the contraction of cardiac muscles. The process begins with generation of an action potential (in the sinoatrial node (SA) in humans) and ends with a change in the rate, frequency, or extent of the contraction of the heart muscles.
 1 Q9H254 (/ISS)
Protein localization to plasma membrane GO:0072659
A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
 1 Q9H254 (/ISS)

There are 30 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
 3 A0A0G2K677 (/IDA) E9PX29 (/IDA) Q8VIE5 (/IDA)
Axon initial segment GO:0043194
Portion of the axon proximal to the neuronal cell body, at the level of the axon hillock. The action potentials that propagate along the axon are generated at the level of this initial segment.
 3 A0A0G2K677 (/IDA) E9PX29 (/IDA) Q8VIE5 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
 2 A0A0G2K677 (/IDA) Q9H254 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
 2 E9PX29 (/ISO) Q8VIE5 (/ISO)
Spectrin GO:0008091
Membrane associated dimeric protein (240 and 220 kDa) of erythrocytes. Forms a complex with ankyrin, actin and probably other components of the membrane cytoskeleton, so that there is a mesh of proteins underlying the plasma membrane, potentially restricting the lateral mobility of integral proteins.
 2 E9PX29 (/ISO) Q8VIE5 (/ISO)
Intercalated disc GO:0014704
A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells.
 2 E9PX29 (/IDA) Q8VIE5 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
 2 E9PX29 (/ISO) Q8VIE5 (/ISO)
Nuclear matrix GO:0016363
The dense fibrillar network lying on the inner side of the nuclear membrane.
 2 E9PX29 (/ISO) Q8VIE5 (/ISO)
PML body GO:0016605
A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection.
 2 E9PX29 (/ISO) Q8VIE5 (/ISO)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
 2 E9PX29 (/ISO) Q8VIE5 (/ISO)
Node of Ranvier GO:0033268
An axon part that is a gap in the myelin where voltage-gated sodium channels cluster and saltatory conduction is executed.
 2 E9PX29 (/ISO) Q8VIE5 (/ISO)
Paranode region of axon GO:0033270
An axon part that is located adjacent to the nodes of Ranvier and surrounded by lateral loop portions of myelin sheath.
 2 E9PX29 (/IDA) Q8VIE5 (/IDA)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
 2 E9PX29 (/IDA) Q8VIE5 (/IDA)
Axon initial segment GO:0043194
Portion of the axon proximal to the neuronal cell body, at the level of the axon hillock. The action potentials that propagate along the axon are generated at the level of this initial segment.
 2 E9PX29 (/ISO) Q8VIE5 (/ISO)
Axon hillock GO:0043203
Portion of the neuronal cell soma from which the axon originates.
 2 E9PX29 (/IDA) Q8VIE5 (/IDA)
Cell body fiber GO:0070852
A neuron projection that is found in unipolar neurons and corresponds to the region between the cell body and the point at which the single projection branches.
 2 E9PX29 (/IDA) Q8VIE5 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
 1 Q9H254 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
 1 Q9H254 (/ISS)
Adherens junction GO:0005912
A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments.
 1 Q9H254 (/ISS)
Spectrin GO:0008091
Membrane associated dimeric protein (240 and 220 kDa) of erythrocytes. Forms a complex with ankyrin, actin and probably other components of the membrane cytoskeleton, so that there is a mesh of proteins underlying the plasma membrane, potentially restricting the lateral mobility of integral proteins.
 1 Q9H254 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
 1 Q9H254 (/IDA)
Nuclear matrix GO:0016363
The dense fibrillar network lying on the inner side of the nuclear membrane.
 1 Q9H254 (/IDA)
PML body GO:0016605
A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection.
 1 Q9H254 (/IDA)
Node of Ranvier GO:0033268
An axon part that is a gap in the myelin where voltage-gated sodium channels cluster and saltatory conduction is executed.
 1 A0A0G2K677 (/IDA)
Node of Ranvier GO:0033268
An axon part that is a gap in the myelin where voltage-gated sodium channels cluster and saltatory conduction is executed.
 1 Q9H254 (/ISS)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
 1 Q9H254 (/ISS)
Axon initial segment GO:0043194
Portion of the axon proximal to the neuronal cell body, at the level of the axon hillock. The action potentials that propagate along the axon are generated at the level of this initial segment.
 1 Q9H254 (/ISS)
Axon hillock GO:0043203
Portion of the neuronal cell soma from which the axon originates.
 1 Q9H254 (/ISS)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
 1 Q9H254 (/HDA)
Cell body fiber GO:0070852
A neuron projection that is found in unipolar neurons and corresponds to the region between the cell body and the point at which the single projection branches.
 1 Q9H254 (/ISS)