The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 14: DNA-binding transcriptional regulator NtrC

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 16 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Phosphorelay response regulator activity GO:0000156
Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response.
103 Q48CE7 (/ISS) Q48CE7 (/ISS) Q48CE7 (/ISS) Q48CE7 (/ISS) Q48CE7 (/ISS) Q48CE7 (/ISS) Q48CE7 (/ISS) Q48CE7 (/ISS) Q48CE7 (/ISS) Q48CE7 (/ISS)
(93 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
69 O67198 (/IPI) P0AFB8 (/IPI) P0AFB8 (/IPI) P0AFB8 (/IPI) P0AFB8 (/IPI) P0AFB8 (/IPI) P0AFB8 (/IPI) P0AFB8 (/IPI) P0AFB8 (/IPI) P0AFB8 (/IPI)
(59 more)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
28 Q06065 (/IDA) Q06065 (/IDA) Q06065 (/IDA) Q06065 (/IDA) Q06065 (/IDA) Q06065 (/IDA) Q06065 (/IDA) Q06065 (/IDA) Q06065 (/IDA) Q06065 (/IDA)
(18 more)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
28 Q06065 (/ISS) Q06065 (/ISS) Q06065 (/ISS) Q06065 (/ISS) Q06065 (/ISS) Q06065 (/ISS) Q06065 (/ISS) Q06065 (/ISS) Q06065 (/ISS) Q06065 (/ISS)
(18 more)
Ornithine decarboxylase inhibitor activity GO:0008073
The stopping, prevention or reduction of the activity of the enzyme ornithine decarboxylase.
28 Q06065 (/IDA) Q06065 (/IDA) Q06065 (/IDA) Q06065 (/IDA) Q06065 (/IDA) Q06065 (/IDA) Q06065 (/IDA) Q06065 (/IDA) Q06065 (/IDA) Q06065 (/IDA)
(18 more)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
19 P14375 (/IDA) P14375 (/IDA) P14375 (/IDA) P14375 (/IDA) P14375 (/IDA) P14375 (/IDA) P14375 (/IDA) P14375 (/IDA) P14375 (/IDA) P14375 (/IDA)
(9 more)
Phosphorelay response regulator activity GO:0000156
Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response.
12 P14375 (/IDA) P14375 (/IDA) P14375 (/IDA) P14375 (/IDA) P14375 (/IDA) P14375 (/IDA) P14375 (/IDA) P14375 (/IDA) P14375 (/IDA) P14375 (/IDA)
(2 more)
Bacterial-type RNA polymerase enhancer sequence-specific DNA binding GO:0001150
Interacting selectively and non-covalently with a sequence of DNA that is an enhancer region that helps activate transcription of a gene or operon by a bacterial-type RNA polymerase. Enhancers for sigma-54 holoenzymes are typically located 80 to 150 base pairs upstream from the transcription start site, although they can be further away or may be downstream of the promoter. Some transcription units dependent on sigma-70 holoenzymes may also include enhancer sequences.
11 P19323 (/IDA) P19323 (/IDA) P19323 (/IDA) P19323 (/IDA) P19323 (/IDA) P19323 (/IDA) P19323 (/IDA) P19323 (/IDA) P19323 (/IDA) P19323 (/IDA)
(1 more)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
11 P19323 (/IDA) P19323 (/IDA) P19323 (/IDA) P19323 (/IDA) P19323 (/IDA) P19323 (/IDA) P19323 (/IDA) P19323 (/IDA) P19323 (/IDA) P19323 (/IDA)
(1 more)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
7 Q88CY1 (/IMP) Q88CY1 (/IMP) Q88CY1 (/IMP) Q88CY1 (/IMP) Q88CY1 (/IMP) Q88CY1 (/IMP) Q88CY1 (/IMP)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
7 Q88CY1 (/IPI) Q88CY1 (/IPI) Q88CY1 (/IPI) Q88CY1 (/IPI) Q88CY1 (/IPI) Q88CY1 (/IPI) Q88CY1 (/IPI)
DNA-binding transcription activator activity GO:0001216
Interacting selectively and non-covalently with a specific DNA sequence in order to activate or increase the frequency, rate or extent of transcription by a RNA polymerase.
7 Q88CY1 (/IPI) Q88CY1 (/IPI) Q88CY1 (/IPI) Q88CY1 (/IPI) Q88CY1 (/IPI) Q88CY1 (/IPI) Q88CY1 (/IPI)
DNA-binding transcription repressor activity GO:0001217
Interacting selectively and non-covalently with a specific DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by a RNA polymerase.
7 Q88CY1 (/IMP) Q88CY1 (/IMP) Q88CY1 (/IMP) Q88CY1 (/IMP) Q88CY1 (/IMP) Q88CY1 (/IMP) Q88CY1 (/IMP)
DNA-binding transcription repressor activity GO:0001217
Interacting selectively and non-covalently with a specific DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by a RNA polymerase.
7 Q88CY1 (/IPI) Q88CY1 (/IPI) Q88CY1 (/IPI) Q88CY1 (/IPI) Q88CY1 (/IPI) Q88CY1 (/IPI) Q88CY1 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
6 C1DI41 (/IPI) C1DI41 (/IPI) C1DI41 (/IPI) O67198 (/IPI) O84957 (/IPI) P12627 (/IPI)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
1 Q5LKZ2 (/ISS)

There are 21 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Phosphorelay signal transduction system GO:0000160
A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins.
103 Q48CE7 (/ISS) Q48CE7 (/ISS) Q48CE7 (/ISS) Q48CE7 (/ISS) Q48CE7 (/ISS) Q48CE7 (/ISS) Q48CE7 (/ISS) Q48CE7 (/ISS) Q48CE7 (/ISS) Q48CE7 (/ISS)
(93 more)
Regulation of nitrogen utilization GO:0006808
Any process that modulates the frequency, rate or extent of nitrogen utilization.
95 Q48CE7 (/ISS) Q48CE7 (/ISS) Q48CE7 (/ISS) Q48CE7 (/ISS) Q48CE7 (/ISS) Q48CE7 (/ISS) Q48CE7 (/ISS) Q48CE7 (/ISS) Q48CE7 (/ISS) Q48CE7 (/ISS)
(85 more)
Regulation of polyamine biosynthetic process GO:0010967
Any process that modulates the frequency, rate or extent of polyamine biosynthesis. Polyamine biosynthesis is the chemical reactions and pathways resulting in the formation of polyamines, any organic compound containing two or more amino groups.
28 Q06065 (/IDA) Q06065 (/IDA) Q06065 (/IDA) Q06065 (/IDA) Q06065 (/IDA) Q06065 (/IDA) Q06065 (/IDA) Q06065 (/IDA) Q06065 (/IDA) Q06065 (/IDA)
(18 more)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
28 Q06065 (/IDA) Q06065 (/IDA) Q06065 (/IDA) Q06065 (/IDA) Q06065 (/IDA) Q06065 (/IDA) Q06065 (/IDA) Q06065 (/IDA) Q06065 (/IDA) Q06065 (/IDA)
(18 more)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
28 Q06065 (/ISS) Q06065 (/ISS) Q06065 (/ISS) Q06065 (/ISS) Q06065 (/ISS) Q06065 (/ISS) Q06065 (/ISS) Q06065 (/ISS) Q06065 (/ISS) Q06065 (/ISS)
(18 more)
Phosphorelay signal transduction system GO:0000160
A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins.
12 P14375 (/IDA) P14375 (/IDA) P14375 (/IDA) P14375 (/IDA) P14375 (/IDA) P14375 (/IDA) P14375 (/IDA) P14375 (/IDA) P14375 (/IDA) P14375 (/IDA)
(2 more)
Transcription, DNA-templated GO:0006351
The cellular synthesis of RNA on a template of DNA.
12 P14375 (/IEP) P14375 (/IEP) P14375 (/IEP) P14375 (/IEP) P14375 (/IEP) P14375 (/IEP) P14375 (/IEP) P14375 (/IEP) P14375 (/IEP) P14375 (/IEP)
(2 more)
Transcription, DNA-templated GO:0006351
The cellular synthesis of RNA on a template of DNA.
12 P14375 (/ISS) P14375 (/ISS) P14375 (/ISS) P14375 (/ISS) P14375 (/ISS) P14375 (/ISS) P14375 (/ISS) P14375 (/ISS) P14375 (/ISS) P14375 (/ISS)
(2 more)
Transcription, DNA-templated GO:0006351
The cellular synthesis of RNA on a template of DNA.
11 P19323 (/IDA) P19323 (/IDA) P19323 (/IDA) P19323 (/IDA) P19323 (/IDA) P19323 (/IDA) P19323 (/IDA) P19323 (/IDA) P19323 (/IDA) P19323 (/IDA)
(1 more)
Protein homotetramerization GO:0051289
The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.
11 P19323 (/IDA) P19323 (/IDA) P19323 (/IDA) P19323 (/IDA) P19323 (/IDA) P19323 (/IDA) P19323 (/IDA) P19323 (/IDA) P19323 (/IDA) P19323 (/IDA)
(1 more)
Positive regulation of DNA-templated transcription, initiation GO:2000144
Any process that activates or increases the frequency, rate or extent of DNA-templated transcription initiation.
11 P19323 (/IDA) P19323 (/IDA) P19323 (/IDA) P19323 (/IDA) P19323 (/IDA) P19323 (/IDA) P19323 (/IDA) P19323 (/IDA) P19323 (/IDA) P19323 (/IDA)
(1 more)
Positive regulation of organic acid transport GO:0032892
Any process that activates or increases the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
10 Q9HU19 (/IMP) Q9HU19 (/IMP) Q9HU19 (/IMP) Q9HU19 (/IMP) Q9HU19 (/IMP) Q9HU19 (/IMP) Q9HU19 (/IMP) Q9HU19 (/IMP) Q9HU19 (/IMP) Q9HU19 (/IMP)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
8 P03029 (/IMP) P03029 (/IMP) P03029 (/IMP) P03029 (/IMP) P03029 (/IMP) P03029 (/IMP) P03029 (/IMP) P03029 (/IMP)
C4-dicarboxylate transport GO:0015740
The directed movement of a C4-dicarboxylate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A C4-dicarboxylate is the anion of a dicarboxylic acid that contains four carbon atoms.
8 Q5LKZ2 (/ISS) Q8ECK1 (/ISS) Q9KQS2 (/ISS) Q9KQS2 (/ISS) Q9KQS2 (/ISS) Q9KQS2 (/ISS) Q9KQS2 (/ISS) Q9KQS2 (/ISS)
Positive regulation of single-species biofilm formation on inanimate substrate GO:1900233
Any process that activates or increases the frequency, rate or extent of single-species biofilm formation on inanimate substrate.
8 Q9HT62 (/IMP) Q9HT62 (/IMP) Q9HT62 (/IMP) Q9HT62 (/IMP) Q9HT62 (/IMP) Q9HT62 (/IMP) Q9HT62 (/IMP) Q9HT62 (/IMP)
DNA-templated transcription, initiation GO:0006352
Any process involved in the assembly of the RNA polymerase preinitiation complex (PIC) at the core promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. The initiation phase ends just before and does not include promoter clearance, or release, which is the transition between the initiation and elongation phases of transcription.
7 P71229 (/IMP) P71229 (/IMP) P71229 (/IMP) P71229 (/IMP) P71229 (/IMP) P71229 (/IMP) P71229 (/IMP)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
7 Q88CY1 (/IDA) Q88CY1 (/IDA) Q88CY1 (/IDA) Q88CY1 (/IDA) Q88CY1 (/IDA) Q88CY1 (/IDA) Q88CY1 (/IDA)
Regulation of DNA-templated transcription, initiation GO:2000142
Any process that modulates the frequency, rate or extent of DNA-templated transcription initiation.
7 P71229 (/IMP) P71229 (/IMP) P71229 (/IMP) P71229 (/IMP) P71229 (/IMP) P71229 (/IMP) P71229 (/IMP)
Response to starvation GO:0042594
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment.
2 Q1D7F8 (/IMP) Q1D7F8 (/IMP)
Regulation of sporulation GO:0043937
Any process that modulates the frequency, rate or extent of sporulation, the process whose specific outcome is the progression of a spore over time, from its initiation to the mature structure.
2 Q1D7F8 (/IMP) Q1D7F8 (/IMP)
Nitrogen fixation GO:0009399
The process in which nitrogen is taken from its relatively inert molecular form (N2) in the atmosphere and converted into nitrogen compounds useful for other chemical processes, such as ammonia, nitrate and nitrogen dioxide.
1 Q5LRP0 (/ISS)

There are 3 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
68 P0AFB8 (/IDA) P0AFB8 (/IDA) P0AFB8 (/IDA) P0AFB8 (/IDA) P0AFB8 (/IDA) P0AFB8 (/IDA) P0AFB8 (/IDA) P0AFB8 (/IDA) P0AFB8 (/IDA) P0AFB8 (/IDA)
(58 more)
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
7 Q88CY1 (/IMP) Q88CY1 (/IMP) Q88CY1 (/IMP) Q88CY1 (/IMP) Q88CY1 (/IMP) Q88CY1 (/IMP) Q88CY1 (/IMP)
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
7 Q88CY1 (/IPI) Q88CY1 (/IPI) Q88CY1 (/IPI) Q88CY1 (/IPI) Q88CY1 (/IPI) Q88CY1 (/IPI) Q88CY1 (/IPI)