The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Peroxidase, domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 4: Catalase-peroxidase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 10 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Catalase activity GO:0004096
Catalysis of the reaction: 2 hydrogen peroxide = O2 + 2 H2O.
34 P13029 (/IDA) P13029 (/IDA) P13029 (/IDA) P13029 (/IDA) P13029 (/IDA) P13029 (/IDA) P13029 (/IDA) P13029 (/IDA) P13029 (/IDA) P13029 (/IDA)
(24 more)
Peroxidase activity GO:0004601
Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O.
33 P13029 (/IDA) P13029 (/IDA) P13029 (/IDA) P13029 (/IDA) P13029 (/IDA) P13029 (/IDA) P13029 (/IDA) P13029 (/IDA) P13029 (/IDA) P13029 (/IDA)
(23 more)
Heme binding GO:0020037
Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.
30 P13029 (/IDA) P13029 (/IDA) P13029 (/IDA) P13029 (/IDA) P13029 (/IDA) P13029 (/IDA) P13029 (/IDA) P13029 (/IDA) P13029 (/IDA) P13029 (/IDA)
(20 more)
Oxidoreductase activity GO:0016491
Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
24 P13029 (/IDA) P13029 (/IDA) P13029 (/IDA) P13029 (/IDA) P13029 (/IDA) P13029 (/IDA) P13029 (/IDA) P13029 (/IDA) P13029 (/IDA) P13029 (/IDA)
(14 more)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
24 P13029 (/IDA) P13029 (/IDA) P13029 (/IDA) P13029 (/IDA) P13029 (/IDA) P13029 (/IDA) P13029 (/IDA) P13029 (/IDA) P13029 (/IDA) P13029 (/IDA)
(14 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
6 P9WIE5 (/IPI) P9WIE5 (/IPI) P9WIE5 (/IPI) P9WIE5 (/IPI) P9WIE5 (/IPI) P9WIE5 (/IPI)
Oxidoreductase activity, acting on a heme group of donors, nitrogenous group as acceptor GO:0016677
Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces a nitrogenous group.
6 P9WIE5 (/IDA) P9WIE5 (/IDA) P9WIE5 (/IDA) P9WIE5 (/IDA) P9WIE5 (/IDA) P9WIE5 (/IDA)
NADPH binding GO:0070402
Interacting selectively and non-covalently with the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions.
6 P9WIE5 (/IDA) P9WIE5 (/IDA) P9WIE5 (/IDA) P9WIE5 (/IDA) P9WIE5 (/IDA) P9WIE5 (/IDA)
NADH binding GO:0070404
Interacting selectively and non-covalently with the reduced form, NADH, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions.
6 P9WIE5 (/IDA) P9WIE5 (/IDA) P9WIE5 (/IDA) P9WIE5 (/IDA) P9WIE5 (/IDA) P9WIE5 (/IDA)
Catalase activity GO:0004096
Catalysis of the reaction: 2 hydrogen peroxide = O2 + 2 H2O.
1 Q96VT4 (/RCA)

There are 12 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Response to oxidative stress GO:0006979
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
24 P13029 (/IEP) P13029 (/IEP) P13029 (/IEP) P13029 (/IEP) P13029 (/IEP) P13029 (/IEP) P13029 (/IEP) P13029 (/IEP) P13029 (/IEP) P13029 (/IEP)
(14 more)
Hydrogen peroxide catabolic process GO:0042744
The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2).
24 P13029 (/IMP) P13029 (/IMP) P13029 (/IMP) P13029 (/IMP) P13029 (/IMP) P13029 (/IMP) P13029 (/IMP) P13029 (/IMP) P13029 (/IMP) P13029 (/IMP)
(14 more)
Cellular response to hydrogen peroxide GO:0070301
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
24 P13029 (/IEP) P13029 (/IEP) P13029 (/IEP) P13029 (/IEP) P13029 (/IEP) P13029 (/IEP) P13029 (/IEP) P13029 (/IEP) P13029 (/IEP) P13029 (/IEP)
(14 more)
Response to oxidative stress GO:0006979
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
6 P9WIE5 (/IMP) P9WIE5 (/IMP) P9WIE5 (/IMP) P9WIE5 (/IMP) P9WIE5 (/IMP) P9WIE5 (/IMP)
Hydrogen peroxide catabolic process GO:0042744
The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2).
6 P9WIE5 (/IDA) P9WIE5 (/IDA) P9WIE5 (/IDA) P9WIE5 (/IDA) P9WIE5 (/IDA) P9WIE5 (/IDA)
Positive regulation of DNA repair GO:0045739
Any process that activates or increases the frequency, rate or extent of DNA repair.
6 P9WIE5 (/IGI) P9WIE5 (/IGI) P9WIE5 (/IGI) P9WIE5 (/IGI) P9WIE5 (/IGI) P9WIE5 (/IGI)
Evasion or tolerance by symbiont of host-produced reactive oxygen species GO:0052059
The process in which an organism avoids the effects of reactive oxygen species produced as a defense response by the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
6 P9WIE5 (/TAS) P9WIE5 (/TAS) P9WIE5 (/TAS) P9WIE5 (/TAS) P9WIE5 (/TAS) P9WIE5 (/TAS)
Response to reactive oxygen species GO:0000302
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals.
1 Q96VT4 (/IEP)
Cellular response to starvation GO:0009267
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment.
1 Q96VT4 (/IEP)
D-gluconate metabolic process GO:0019521
The chemical reactions and pathways involving D-gluconate, the anion of D-gluconic acid, the aldonic acid derived from glucose.
1 Q96VT4 (/RCA)
Sexual reproduction GO:0019953
A reproduction process that creates a new organism by combining the genetic material of two gametes, which may come from two organisms or from a single organism, in the case of self-fertilizing hermaphrodites, e.g. C. elegans, or self-fertilization in plants. It occurs both in eukaryotes and prokaryotes: in multicellular eukaryotic organisms, an individual is created anew; in prokaryotes, the initial cell has additional or transformed genetic material. In a process called genetic recombination, genetic material (DNA) originating from two gametes join up so that homologous sequences are aligned with each other, and this is followed by exchange of genetic information. After the new recombinant chromosome is formed, it is passed on to progeny.
1 Q96VT4 (/IEP)
Cellular response to heat GO:0034605
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
1 Q96VT4 (/IEP)

There are 8 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
30 P13029 (/HDA) P13029 (/HDA) P13029 (/HDA) P13029 (/HDA) P13029 (/HDA) P13029 (/HDA) P13029 (/HDA) P13029 (/HDA) P13029 (/HDA) P13029 (/HDA)
(20 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
30 P13029 (/IDA) P13029 (/IDA) P13029 (/IDA) P13029 (/IDA) P13029 (/IDA) P13029 (/IDA) P13029 (/IDA) P13029 (/IDA) P13029 (/IDA) P13029 (/IDA)
(20 more)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
6 P9WIE5 (/HDA) P9WIE5 (/HDA) P9WIE5 (/HDA) P9WIE5 (/HDA) P9WIE5 (/HDA) P9WIE5 (/HDA)
Cell wall GO:0005618
The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins.
6 P9WIE5 (/HDA) P9WIE5 (/HDA) P9WIE5 (/HDA) P9WIE5 (/HDA) P9WIE5 (/HDA) P9WIE5 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
6 P9WIE5 (/TAS) P9WIE5 (/TAS) P9WIE5 (/TAS) P9WIE5 (/TAS) P9WIE5 (/TAS) P9WIE5 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
6 P9WIE5 (/HDA) P9WIE5 (/HDA) P9WIE5 (/HDA) P9WIE5 (/HDA) P9WIE5 (/HDA) P9WIE5 (/HDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
1 Q96VT4 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q96VT4 (/IDA)