The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
High mobility group box domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 9: Histone-lysine N-methyltransferase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 13 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
4 O14686 (/IPI) Q6PDK2 (/IPI) Q8BRH4 (/IPI) Q8NEZ4 (/IPI)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
3 A0A0B4LGG6 (/IDA) Q961F0 (/IDA) Q9W1H0 (/IDA)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
3 A0A0B4LGG6 (/ISM) Q961F0 (/ISM) Q9W1H0 (/ISM)
Nuclear receptor transcription coactivator activity GO:0030374
The function of a transcription cofactor that activates transcription in conjuction with a ligand-dependent nuclear receptor from a RNA polymerase II promoter; does not bind DNA itself.
3 A0A0B4LGG6 (/IDA) Q961F0 (/IDA) Q9W1H0 (/IDA)
Histone binding GO:0042393
Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity.
3 A0A0B4LGG6 (/IDA) Q961F0 (/IDA) Q9W1H0 (/IDA)
Histone methyltransferase activity (H3-K4 specific) GO:0042800
Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 4) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 4). This reaction is the addition of a methyl group onto lysine at position 4 of the histone H3 protein.
2 G5EGI1 (/IDA) Q8NEZ4 (/IDA)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
1 O14686 (/ISM)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
1 O14686 (/NAS)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
1 Q8NEZ4 (/HDA)
Histone methyltransferase activity (H3-K4 specific) GO:0042800
Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 4) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 4). This reaction is the addition of a methyl group onto lysine at position 4 of the histone H3 protein.
1 Q8BRH4 (/ISO)
Histone methyltransferase activity (H3-K4 specific) GO:0042800
Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 4) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 4). This reaction is the addition of a methyl group onto lysine at position 4 of the histone H3 protein.
1 O14686 (/TAS)
Transcription regulatory region DNA binding GO:0044212
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
1 O14686 (/IDA)
Transcription regulatory region DNA binding GO:0044212
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
1 Q6PDK2 (/ISO)

There are 35 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
4 A0A0B4LGG6 (/IMP) O14686 (/IMP) Q961F0 (/IMP) Q9W1H0 (/IMP)
Histone H3-K4 methylation GO:0051568
The modification of histone H3 by addition of one or more methyl groups to lysine at position 4 of the histone.
4 A0A0B4LGG6 (/IDA) G5EGI1 (/IDA) Q961F0 (/IDA) Q9W1H0 (/IDA)
Imaginal disc-derived wing vein specification GO:0007474
The regionalization process in which the area of a imaginal disc-derived wing that will form a wing vein is specified.
3 A0A0B4LGG6 (/IMP) Q961F0 (/IMP) Q9W1H0 (/IMP)
Imaginal disc-derived wing vein morphogenesis GO:0008586
The process in which anatomical structures of the veins on an imaginal disc-derived wing are generated and organized.
3 A0A0B4LGG6 (/IGI) Q961F0 (/IGI) Q9W1H0 (/IGI)
Imaginal disc-derived wing vein morphogenesis GO:0008586
The process in which anatomical structures of the veins on an imaginal disc-derived wing are generated and organized.
3 A0A0B4LGG6 (/IMP) Q961F0 (/IMP) Q9W1H0 (/IMP)
Ecdysis, chitin-based cuticle GO:0018990
The shedding of the old chitin-based cuticlar fragments during the molting cycle. An example of this is found in Drosophila melanogaster.
3 A0A0B4LGG6 (/IMP) Q961F0 (/IMP) Q9W1H0 (/IMP)
Ecdysone receptor-mediated signaling pathway GO:0035076
The series of molecular signals generated by ecdysone binding to the ecdysone receptor complex.
3 A0A0B4LGG6 (/IGI) Q961F0 (/IGI) Q9W1H0 (/IGI)
Cellular response to ecdysone GO:0071390
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ecdysone stimulus.
3 A0A0B4LGG6 (/IMP) Q961F0 (/IMP) Q9W1H0 (/IMP)
Positive regulation of histone H3-K9 trimethylation GO:1900114
Any process that activates or increases the frequency, rate or extent of histone H3-K9 trimethylation.
3 A0A0B4LGG6 (/IMP) Q961F0 (/IMP) Q9W1H0 (/IMP)
Regulation of gene expression GO:0010468
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
2 Q6PDK2 (/IMP) Q8BRH4 (/IMP)
Regulation of megakaryocyte differentiation GO:0045652
Any process that modulates the frequency, rate or extent of megakaryocyte differentiation.
2 O14686 (/TAS) Q8NEZ4 (/TAS)
Oocyte growth GO:0001555
The developmental growth process in which an oocyte irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present.
1 Q6PDK2 (/IMP)
Oocyte growth GO:0001555
The developmental growth process in which an oocyte irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present.
1 O14686 (/ISS)
In utero embryonic development GO:0001701
The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.
1 Q6PDK2 (/IMP)
Chromatin silencing GO:0006342
Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin.
1 Q6PDK2 (/IMP)
Chromatin silencing GO:0006342
Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin.
1 O14686 (/ISS)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
1 O14686 (/NAS)
Single fertilization GO:0007338
The union of male and female gametes to form a zygote.
1 Q8BRH4 (/IMP)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
1 O14686 (/IMP)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
1 Q6PDK2 (/ISO)
Histone methylation GO:0016571
The modification of histones by addition of methyl groups.
1 Q8BRH4 (/IDA)
Positive regulation of intracellular estrogen receptor signaling pathway GO:0033148
Any process that activates or increases the frequency, rate or extent of the activity of an intracellular estrogen receptor signaling pathway.
1 O14686 (/IMP)
Positive regulation of intracellular estrogen receptor signaling pathway GO:0033148
Any process that activates or increases the frequency, rate or extent of the activity of an intracellular estrogen receptor signaling pathway.
1 Q6PDK2 (/ISO)
Multicellular organism growth GO:0035264
The increase in size or mass of an entire multicellular organism, as opposed to cell growth.
1 Q8BRH4 (/IMP)
Regulation of vulval development GO:0040028
Any process that modulates the frequency, rate or extent of development of the vulva. Vulval development is the process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult.
1 G5EGI1 (/IGI)
Response to estrogen GO:0043627
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics.
1 O14686 (/IDA)
Response to estrogen GO:0043627
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics.
1 Q6PDK2 (/ISO)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 Q6PDK2 (/ISO)
Positive regulation of fibroblast proliferation GO:0048146
Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells.
1 Q8BRH4 (/IMP)
Oogenesis GO:0048477
The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster.
1 Q6PDK2 (/IMP)
Oogenesis GO:0048477
The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster.
1 O14686 (/ISS)
Histone H3-K4 methylation GO:0051568
The modification of histone H3 by addition of one or more methyl groups to lysine at position 4 of the histone.
1 Q6PDK2 (/IMP)
Histone H3-K4 methylation GO:0051568
The modification of histone H3 by addition of one or more methyl groups to lysine at position 4 of the histone.
1 O14686 (/ISS)
Eyelid development in camera-type eye GO:0061029
The progression of the eyelid in a camera-type eye from its formation to the mature state. The eyelid is a membranous cover that helps protect and lubricate the eye.
1 Q8BRH4 (/IMP)
Beta-catenin-TCF complex assembly GO:1904837
The aggregation, arrangement and bonding together of a set of components to form a beta-catenin-TCF complex.
1 O14686 (/TAS)

There are 11 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
MLL3/4 complex GO:0044666
A protein complex that can methylate lysine-4 of histone H3, and which contains either of the protein subunits MLL3 or MLL4 in mammals, or equivalent in other species.
6 A0A0B4LGG6 (/IDA) G5EGI1 (/IDA) O14686 (/IDA) Q8NEZ4 (/IDA) Q961F0 (/IDA) Q9W1H0 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
4 O14686 (/TAS) Q6PDK2 (/TAS) Q8BRH4 (/TAS) Q8NEZ4 (/TAS)
Polytene chromosome GO:0005700
A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible.
3 A0A0B4LGG6 (/IDA) Q961F0 (/IDA) Q9W1H0 (/IDA)
Ecdysone receptor holocomplex GO:0008230
A heterodimeric complex containing the products of the insect genes Ecdysone receptor (EcR) and ultraspiracle (usp). Binding of ecdysone promotes association between the two subunits, and the receptor complex then initiates molting and metamorphosis by binding DNA and regulating the transcription of target genes.
3 A0A0B4LGG6 (/IPI) Q961F0 (/IPI) Q9W1H0 (/IPI)
Histone methyltransferase complex GO:0035097
A multimeric complex that is able to catalyze the addition of methyl groups to histone proteins.
2 Q6PDK2 (/ISO) Q8BRH4 (/ISO)
MLL3/4 complex GO:0044666
A protein complex that can methylate lysine-4 of histone H3, and which contains either of the protein subunits MLL3 or MLL4 in mammals, or equivalent in other species.
2 Q6PDK2 (/ISO) Q8BRH4 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q8NEZ4 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q8BRH4 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 O14686 (/NAS)
Histone methyltransferase complex GO:0035097
A multimeric complex that is able to catalyze the addition of methyl groups to histone proteins.
1 Q8NEZ4 (/IDA)
Histone methyltransferase complex GO:0035097
A multimeric complex that is able to catalyze the addition of methyl groups to histone proteins.
1 O14686 (/IPI)