The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"High mobility group box domain
".
FunFam 18: High mobility group protein B2
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 48 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Drug binding GO:0008144
Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease.
|
202 |
A0A087QNV0 (/ISS)
A0A087QNV0 (/ISS)
A0A087QNV0 (/ISS)
A0A087QNV0 (/ISS)
A0A091F7A2 (/ISS)
A0A091GCL3 (/ISS)
A0A091GCL3 (/ISS)
A0A091H0T5 (/ISS)
A0A091IH21 (/ISS)
A0A091KT98 (/ISS)
(192 more) |
|
Four-way junction DNA binding GO:0000400
Interacting selectively and non-covalently with DNA containing four-way junctions, also known as Holliday junctions, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices.
|
193 |
A0A087QNV0 (/ISS)
A0A087QNV0 (/ISS)
A0A087QNV0 (/ISS)
A0A087QNV0 (/ISS)
A0A087VBG6 (/ISS)
A0A091F7A2 (/ISS)
A0A091GCL3 (/ISS)
A0A091GCL3 (/ISS)
A0A091H0T5 (/ISS)
A0A091IH21 (/ISS)
(183 more) |
|
DNA binding, bending GO:0008301
The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence.
|
190 |
A0A087QNV0 (/ISS)
A0A087QNV0 (/ISS)
A0A087QNV0 (/ISS)
A0A087QNV0 (/ISS)
A0A087VBG6 (/ISS)
A0A091F7A2 (/ISS)
A0A091GCL3 (/ISS)
A0A091GCL3 (/ISS)
A0A091H0T5 (/ISS)
A0A091IH21 (/ISS)
(180 more) |
|
Enhancer sequence-specific DNA binding GO:0001158
Interacting selectively and non-covalently with a specific sequence of DNA that is part of an enhancer, a transcription regulatory region that is somewhat distal from the core promoter and which enhances transcription from that promoter.
|
180 |
A0A091GCL3 (/ISS)
A0A091GCL3 (/ISS)
A0A091H0T5 (/ISS)
A0A091KT98 (/ISS)
A0A091KT98 (/ISS)
A0A091PGF7 (/ISS)
A0A091PGF7 (/ISS)
A0A091PGF7 (/ISS)
A0A093RXY1 (/ISS)
A0A093RXY1 (/ISS)
(170 more) |
|
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
|
180 |
A0A091GCL3 (/ISS)
A0A091GCL3 (/ISS)
A0A091H0T5 (/ISS)
A0A091KT98 (/ISS)
A0A091KT98 (/ISS)
A0A091PGF7 (/ISS)
A0A091PGF7 (/ISS)
A0A091PGF7 (/ISS)
A0A093RXY1 (/ISS)
A0A093RXY1 (/ISS)
(170 more) |
|
Supercoiled DNA binding GO:0097100
Interacting selectively and non-covalently with supercoiled DNA. For example, during replication and transcription, template DNA is negatively supercoiled in the receding downstream DNA and positively supercoiled in the approaching downstream DNA.
|
157 |
A0A096MR30 (/ISS)
A0A096MR30 (/ISS)
A0A096MR30 (/ISS)
A0A096MR30 (/ISS)
A0A2J8R9D1 (/ISS)
A0A2J8R9D1 (/ISS)
A0A2J8R9D1 (/ISS)
A0A2J8R9D1 (/ISS)
D2GUW1 (/ISS)
D2GUW1 (/ISS)
(147 more) |
|
Non-sequence-specific DNA binding, bending GO:0044378
The activity of binding selectively and non-covalently to DNA in a sequence-independent manner and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence.
|
153 |
A0A096MR30 (/ISS)
A0A096MR30 (/ISS)
A0A096MR30 (/ISS)
A0A096MR30 (/ISS)
A0A2J8R9D1 (/ISS)
A0A2J8R9D1 (/ISS)
A0A2J8R9D1 (/ISS)
A0A2J8R9D1 (/ISS)
D2GUW1 (/ISS)
D2GUW1 (/ISS)
(143 more) |
|
Double-stranded DNA binding GO:0003690
Interacting selectively and non-covalently with double-stranded DNA.
|
142 |
A0A096MR30 (/ISS)
A0A096MR30 (/ISS)
A0A096MR30 (/ISS)
A0A096MR30 (/ISS)
A0A2J8R9D1 (/ISS)
A0A2J8R9D1 (/ISS)
A0A2J8R9D1 (/ISS)
A0A2J8R9D1 (/ISS)
D2GUW1 (/ISS)
D2GUW1 (/ISS)
(132 more) |
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
131 |
A0A096MR30 (/ISS)
A0A096MR30 (/ISS)
A0A096MR30 (/ISS)
A0A096MR30 (/ISS)
A0A2J8R9D1 (/ISS)
A0A2J8R9D1 (/ISS)
A0A2J8R9D1 (/ISS)
A0A2J8R9D1 (/ISS)
D2GUW1 (/ISS)
D2GUW1 (/ISS)
(121 more) |
|
Single-stranded DNA binding GO:0003697
Interacting selectively and non-covalently with single-stranded DNA.
|
117 |
A0A096MR30 (/ISS)
A0A096MR30 (/ISS)
A0A096MR30 (/ISS)
A0A096MR30 (/ISS)
A0A2J8R9D1 (/ISS)
A0A2J8R9D1 (/ISS)
A0A2J8R9D1 (/ISS)
A0A2J8R9D1 (/ISS)
D2GUW1 (/ISS)
D2GUW1 (/ISS)
(107 more) |
|
DNA binding, bending GO:0008301
The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence.
|
25 |
F1NPU8 (/IDA)
P17741 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
(15 more) |
|
Damaged DNA binding GO:0003684
Interacting selectively and non-covalently with damaged DNA.
|
22 |
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
(12 more) |
|
Double-stranded DNA binding GO:0003690
Interacting selectively and non-covalently with double-stranded DNA.
|
14 |
F1RJ01 (/IDA)
P17741 (/IDA)
P30681 (/IDA)
P40673 (/IDA)
P40673 (/IDA)
P40673 (/IDA)
P40673 (/IDA)
P40673 (/IDA)
P40673 (/IDA)
P40673 (/IDA)
(4 more) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
13 |
P23497 (/IPI)
P26583 (/IPI)
P26583 (/IPI)
P26583 (/IPI)
P26583 (/IPI)
P26583 (/IPI)
P26583 (/IPI)
P26583 (/IPI)
P26583 (/IPI)
P26583 (/IPI)
(3 more) |
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
11 |
P26583 (/IMP)
P26583 (/IMP)
P26583 (/IMP)
P26583 (/IMP)
P26583 (/IMP)
P26583 (/IMP)
P26583 (/IMP)
P26583 (/IMP)
P26583 (/IMP)
P26583 (/IMP)
(1 more) |
|
Single-stranded DNA binding GO:0003697
Interacting selectively and non-covalently with single-stranded DNA.
|
11 |
P40673 (/IDA)
P40673 (/IDA)
P40673 (/IDA)
P40673 (/IDA)
P40673 (/IDA)
P40673 (/IDA)
P40673 (/IDA)
P40673 (/IDA)
P40673 (/IDA)
P40673 (/IDA)
(1 more) |
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
11 |
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
(1 more) |
|
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
|
11 |
P26583 (/HDA)
P26583 (/HDA)
P26583 (/HDA)
P26583 (/HDA)
P26583 (/HDA)
P26583 (/HDA)
P26583 (/HDA)
P26583 (/HDA)
P26583 (/HDA)
P26583 (/HDA)
(1 more) |
|
Chemoattractant activity GO:0042056
Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a higher concentration of that signal.
|
11 |
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
(1 more) |
|
Histone binding GO:0042393
Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity.
|
11 |
P40673 (/IDA)
P40673 (/IDA)
P40673 (/IDA)
P40673 (/IDA)
P40673 (/IDA)
P40673 (/IDA)
P40673 (/IDA)
P40673 (/IDA)
P40673 (/IDA)
P40673 (/IDA)
(1 more) |
|
Transcription regulatory region DNA binding GO:0044212
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
|
11 |
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
(1 more) |
|
RAGE receptor binding GO:0050786
Interacting selectively and non-covalently with the RAGE receptor, the receptor for advanced glycation end-products.
|
11 |
P26583 (/IGI)
P26583 (/IGI)
P26583 (/IGI)
P26583 (/IGI)
P26583 (/IGI)
P26583 (/IGI)
P26583 (/IGI)
P26583 (/IGI)
P26583 (/IGI)
P26583 (/IGI)
(1 more) |
|
Four-way junction DNA binding GO:0000400
Interacting selectively and non-covalently with DNA containing four-way junctions, also known as Holliday junctions, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices.
|
2 | F1NPU8 (/IDA) P26584 (/IDA) |
|
Enhancer sequence-specific DNA binding GO:0001158
Interacting selectively and non-covalently with a specific sequence of DNA that is part of an enhancer, a transcription regulatory region that is somewhat distal from the core promoter and which enhances transcription from that promoter.
|
2 | P30681 (/IDA) Q3U566 (/IDA) |
|
Double-stranded DNA binding GO:0003690
Interacting selectively and non-covalently with double-stranded DNA.
|
2 | F1RJ01 (/IMP) P17741 (/IMP) |
|
Single-stranded DNA binding GO:0003697
Interacting selectively and non-covalently with single-stranded DNA.
|
2 | F1RJ01 (/IMP) P17741 (/IMP) |
|
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
|
2 | P30681 (/IDA) Q3U566 (/IDA) |
|
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
|
2 | P23497 (/IPI) P30681 (/IPI) |
|
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
|
2 | F1RJ01 (/ISS) P17741 (/ISS) |
|
Non-sequence-specific DNA binding, bending GO:0044378
The activity of binding selectively and non-covalently to DNA in a sequence-independent manner and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence.
|
2 | F1RJ01 (/IDA) P17741 (/IDA) |
|
Supercoiled DNA binding GO:0097100
Interacting selectively and non-covalently with supercoiled DNA. For example, during replication and transcription, template DNA is negatively supercoiled in the receding downstream DNA and positively supercoiled in the approaching downstream DNA.
|
2 | F1RJ01 (/IDA) P17741 (/IDA) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
1 | P23497 (/IDA) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
1 | P23497 (/ISM) |
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
1 | P17741 (/IDA) |
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
1 | P30681 (/ISO) |
|
Damaged DNA binding GO:0003684
Interacting selectively and non-covalently with damaged DNA.
|
1 | P30681 (/ISO) |
|
Double-stranded DNA binding GO:0003690
Interacting selectively and non-covalently with double-stranded DNA.
|
1 | P52925 (/TAS) |
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
1 | P30681 (/ISO) |
|
Drug binding GO:0008144
Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease.
|
1 | Q3U566 (/IDA) |
|
Lipid binding GO:0008289
Interacting selectively and non-covalently with a lipid.
|
1 | P52925 (/IDA) |
|
DNA binding, bending GO:0008301
The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence.
|
1 | P30681 (/ISO) |
|
Kinase binding GO:0019900
Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group.
|
1 | P23497 (/IPI) |
|
Nucleosomal histone binding GO:0031493
Interacting selectively and non-covalently with a histone that is assembled into a nucleosome.
|
1 | P52925 (/IDA) |
|
Chemoattractant activity GO:0042056
Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a higher concentration of that signal.
|
1 | P30681 (/ISO) |
|
Transcription regulatory region DNA binding GO:0044212
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
|
1 | P30681 (/ISO) |
|
Protein dimerization activity GO:0046983
The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.
|
1 | P23497 (/IPI) |
|
RAGE receptor binding GO:0050786
Interacting selectively and non-covalently with the RAGE receptor, the receptor for advanced glycation end-products.
|
1 | P30681 (/ISO) |
|
Chromo shadow domain binding GO:0070087
Interacting selectively and non-covalently with a chromo shadow domain, a protein domain that is distantly related, and found in association with, the chromo domain.
|
1 | P23497 (/IPI) |
There are 101 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Inflammatory response to antigenic stimulus GO:0002437
An inflammatory response to an antigenic stimulus, which can be include any number of T cell or B cell epitopes.
|
202 |
A0A087QNV0 (/ISS)
A0A087QNV0 (/ISS)
A0A087QNV0 (/ISS)
A0A087QNV0 (/ISS)
A0A091F7A2 (/ISS)
A0A091GCL3 (/ISS)
A0A091GCL3 (/ISS)
A0A091H0T5 (/ISS)
A0A091IH21 (/ISS)
A0A091KT98 (/ISS)
(192 more) |
|
Response to lipopolysaccharide GO:0032496
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
|
202 |
A0A087QNV0 (/ISS)
A0A087QNV0 (/ISS)
A0A087QNV0 (/ISS)
A0A087QNV0 (/ISS)
A0A091F7A2 (/ISS)
A0A091GCL3 (/ISS)
A0A091GCL3 (/ISS)
A0A091H0T5 (/ISS)
A0A091IH21 (/ISS)
A0A091KT98 (/ISS)
(192 more) |
|
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
|
202 |
A0A087QNV0 (/ISS)
A0A087QNV0 (/ISS)
A0A087QNV0 (/ISS)
A0A087QNV0 (/ISS)
A0A091F7A2 (/ISS)
A0A091GCL3 (/ISS)
A0A091GCL3 (/ISS)
A0A091H0T5 (/ISS)
A0A091IH21 (/ISS)
A0A091KT98 (/ISS)
(192 more) |
|
Defense response to Gram-negative bacterium GO:0050829
Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.
|
196 |
A0A060Y547 (/ISS)
A0A087QNV0 (/ISS)
A0A087QNV0 (/ISS)
A0A087QNV0 (/ISS)
A0A087QNV0 (/ISS)
A0A087VBG6 (/ISS)
A0A091F7A2 (/ISS)
A0A091GCL3 (/ISS)
A0A091GCL3 (/ISS)
A0A091H0T5 (/ISS)
(186 more) |
|
DNA geometric change GO:0032392
The process in which a transformation is induced in the geometry of a DNA double helix, resulting in a change in twist, writhe, or both, but with no change in linking number. Includes the unwinding of double-stranded DNA by helicases.
|
193 |
A0A087QNV0 (/ISS)
A0A087QNV0 (/ISS)
A0A087QNV0 (/ISS)
A0A087QNV0 (/ISS)
A0A087VBG6 (/ISS)
A0A091F7A2 (/ISS)
A0A091GCL3 (/ISS)
A0A091GCL3 (/ISS)
A0A091H0T5 (/ISS)
A0A091IH21 (/ISS)
(183 more) |
|
Defense response to Gram-positive bacterium GO:0050830
Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism.
|
191 |
A0A087QNV0 (/ISS)
A0A087QNV0 (/ISS)
A0A087QNV0 (/ISS)
A0A087QNV0 (/ISS)
A0A087VBG6 (/ISS)
A0A091F7A2 (/ISS)
A0A091GCL3 (/ISS)
A0A091GCL3 (/ISS)
A0A091H0T5 (/ISS)
A0A091IH21 (/ISS)
(181 more) |
|
Regulation of neurogenesis GO:0050767
Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system.
|
180 |
A0A091GCL3 (/ISS)
A0A091GCL3 (/ISS)
A0A091H0T5 (/ISS)
A0A091KT98 (/ISS)
A0A091KT98 (/ISS)
A0A091PGF7 (/ISS)
A0A091PGF7 (/ISS)
A0A091PGF7 (/ISS)
A0A093RXY1 (/ISS)
A0A093RXY1 (/ISS)
(170 more) |
|
Regulation of stem cell proliferation GO:0072091
Any process that modulates the frequency, rate or extent of stem cell proliferation. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.
|
180 |
A0A091GCL3 (/ISS)
A0A091GCL3 (/ISS)
A0A091H0T5 (/ISS)
A0A091KT98 (/ISS)
A0A091KT98 (/ISS)
A0A091PGF7 (/ISS)
A0A091PGF7 (/ISS)
A0A091PGF7 (/ISS)
A0A093RXY1 (/ISS)
A0A093RXY1 (/ISS)
(170 more) |
|
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
169 |
A0A091GCL3 (/ISS)
A0A091GCL3 (/ISS)
A0A091H0T5 (/ISS)
A0A091KT98 (/ISS)
A0A091KT98 (/ISS)
A0A091PGF7 (/ISS)
A0A091PGF7 (/ISS)
A0A091PGF7 (/ISS)
A0A093RXY1 (/ISS)
A0A093RXY1 (/ISS)
(159 more) |
|
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
169 |
A0A091GCL3 (/ISS)
A0A091GCL3 (/ISS)
A0A091H0T5 (/ISS)
A0A091KT98 (/ISS)
A0A091KT98 (/ISS)
A0A091PGF7 (/ISS)
A0A091PGF7 (/ISS)
A0A091PGF7 (/ISS)
A0A093RXY1 (/ISS)
A0A093RXY1 (/ISS)
(159 more) |
|
DNA topological change GO:0006265
The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.
|
142 |
A0A096MR30 (/ISS)
A0A096MR30 (/ISS)
A0A096MR30 (/ISS)
A0A096MR30 (/ISS)
A0A2J8R9D1 (/ISS)
A0A2J8R9D1 (/ISS)
A0A2J8R9D1 (/ISS)
A0A2J8R9D1 (/ISS)
D2GUW1 (/ISS)
D2GUW1 (/ISS)
(132 more) |
|
Nucleosome assembly GO:0006334
The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA.
|
109 |
A0A096MR30 (/ISS)
A0A096MR30 (/ISS)
A0A096MR30 (/ISS)
A0A096MR30 (/ISS)
A0A2J8R9D1 (/ISS)
A0A2J8R9D1 (/ISS)
A0A2J8R9D1 (/ISS)
A0A2J8R9D1 (/ISS)
D2GUW1 (/ISS)
D2GUW1 (/ISS)
(99 more) |
|
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
16 |
F1RJ01 (/ISS)
P17741 (/ISS)
P26584 (/ISS)
P30681 (/ISS)
P40673 (/ISS)
P40673 (/ISS)
P40673 (/ISS)
P40673 (/ISS)
P40673 (/ISS)
P40673 (/ISS)
(6 more) |
|
Defense response to Gram-negative bacterium GO:0050829
Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.
|
15 |
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
(5 more) |
|
Defense response to Gram-positive bacterium GO:0050830
Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism.
|
14 |
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
(4 more) |
|
DNA topological change GO:0006265
The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.
|
13 |
F1RJ01 (/IDA)
P17741 (/IDA)
P40673 (/IDA)
P40673 (/IDA)
P40673 (/IDA)
P40673 (/IDA)
P40673 (/IDA)
P40673 (/IDA)
P40673 (/IDA)
P40673 (/IDA)
(3 more) |
|
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
12 |
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
(2 more) |
|
Positive regulation of DNA binding GO:0043388
Any process that increases the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid).
|
12 |
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
(2 more) |
|
Positive regulation of endothelial cell proliferation GO:0001938
Any process that activates or increases the rate or extent of endothelial cell proliferation.
|
11 |
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
(1 more) |
|
Apoptotic DNA fragmentation GO:0006309
The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments.
|
11 |
P26583 (/TAS)
P26583 (/TAS)
P26583 (/TAS)
P26583 (/TAS)
P26583 (/TAS)
P26583 (/TAS)
P26583 (/TAS)
P26583 (/TAS)
P26583 (/TAS)
P26583 (/TAS)
(1 more) |
|
DNA recombination GO:0006310
Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
|
11 |
P40673 (/IDA)
P40673 (/IDA)
P40673 (/IDA)
P40673 (/IDA)
P40673 (/IDA)
P40673 (/IDA)
P40673 (/IDA)
P40673 (/IDA)
P40673 (/IDA)
P40673 (/IDA)
(1 more) |
|
Chromatin organization GO:0006325
Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin.
|
11 |
P26583 (/NAS)
P26583 (/NAS)
P26583 (/NAS)
P26583 (/NAS)
P26583 (/NAS)
P26583 (/NAS)
P26583 (/NAS)
P26583 (/NAS)
P26583 (/NAS)
P26583 (/NAS)
(1 more) |
|
Nucleosome assembly GO:0006334
The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA.
|
11 |
P26583 (/NAS)
P26583 (/NAS)
P26583 (/NAS)
P26583 (/NAS)
P26583 (/NAS)
P26583 (/NAS)
P26583 (/NAS)
P26583 (/NAS)
P26583 (/NAS)
P26583 (/NAS)
(1 more) |
|
Chromatin remodeling GO:0006338
Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation.
|
11 |
P40673 (/NAS)
P40673 (/NAS)
P40673 (/NAS)
P40673 (/NAS)
P40673 (/NAS)
P40673 (/NAS)
P40673 (/NAS)
P40673 (/NAS)
P40673 (/NAS)
P40673 (/NAS)
(1 more) |
|
Positive regulation of nuclease activity GO:0032075
Any process that activates or increases the frequency, rate or extent of nuclease activity, the hydrolysis of ester linkages within nucleic acids.
|
11 |
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
(1 more) |
|
V(D)J recombination GO:0033151
The process in which immune receptor V, D, and J, or V and J gene segments, depending on the specific receptor, are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS).
|
11 |
P40673 (/IDA)
P40673 (/IDA)
P40673 (/IDA)
P40673 (/IDA)
P40673 (/IDA)
P40673 (/IDA)
P40673 (/IDA)
P40673 (/IDA)
P40673 (/IDA)
P40673 (/IDA)
(1 more) |
|
V(D)J recombination GO:0033151
The process in which immune receptor V, D, and J, or V and J gene segments, depending on the specific receptor, are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS).
|
11 |
P26583 (/ISS)
P26583 (/ISS)
P26583 (/ISS)
P26583 (/ISS)
P26583 (/ISS)
P26583 (/ISS)
P26583 (/ISS)
P26583 (/ISS)
P26583 (/ISS)
P26583 (/ISS)
(1 more) |
|
Positive regulation of erythrocyte differentiation GO:0045648
Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation.
|
11 |
P26583 (/IMP)
P26583 (/IMP)
P26583 (/IMP)
P26583 (/IMP)
P26583 (/IMP)
P26583 (/IMP)
P26583 (/IMP)
P26583 (/IMP)
P26583 (/IMP)
P26583 (/IMP)
(1 more) |
|
Positive regulation of megakaryocyte differentiation GO:0045654
Any process that activates or increases the frequency, rate or extent of megakaryocyte differentiation.
|
11 |
P26583 (/IMP)
P26583 (/IMP)
P26583 (/IMP)
P26583 (/IMP)
P26583 (/IMP)
P26583 (/IMP)
P26583 (/IMP)
P26583 (/IMP)
P26583 (/IMP)
P26583 (/IMP)
(1 more) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
11 |
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
(1 more) |
|
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
11 |
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
(1 more) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
11 |
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
(1 more) |
|
DNA ligation involved in DNA repair GO:0051103
The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase, that contributes to DNA repair.
|
11 |
P26583 (/ISS)
P26583 (/ISS)
P26583 (/ISS)
P26583 (/ISS)
P26583 (/ISS)
P26583 (/ISS)
P26583 (/ISS)
P26583 (/ISS)
P26583 (/ISS)
P26583 (/ISS)
(1 more) |
|
Cell chemotaxis GO:0060326
The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
|
11 |
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
(1 more) |
|
Cellular response to lipopolysaccharide GO:0071222
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
|
11 |
P26583 (/IEP)
P26583 (/IEP)
P26583 (/IEP)
P26583 (/IEP)
P26583 (/IEP)
P26583 (/IEP)
P26583 (/IEP)
P26583 (/IEP)
P26583 (/IEP)
P26583 (/IEP)
(1 more) |
|
Telomere maintenance GO:0000723
Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences.
|
3 | Q9N1Q5 (/ISS) Q9N1Q6 (/ISS) Q9N1Q7 (/ISS) |
|
Negative regulation of endothelial cell migration GO:0010596
Any process that decreases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.
|
3 | Q9N1Q5 (/ISS) Q9N1Q6 (/ISS) Q9N1Q7 (/ISS) |
|
Regulation of angiogenesis GO:0045765
Any process that modulates the frequency, rate or extent of angiogenesis.
|
3 | Q9N1Q5 (/ISS) Q9N1Q6 (/ISS) Q9N1Q7 (/ISS) |
|
Negative regulation of protein export from nucleus GO:0046826
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of proteins from the nucleus into the cytoplasm.
|
3 | Q9N1Q5 (/ISS) Q9N1Q6 (/ISS) Q9N1Q7 (/ISS) |
|
Regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041
Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors.
|
3 | Q9N1Q5 (/ISS) Q9N1Q6 (/ISS) Q9N1Q7 (/ISS) |
|
Regulation of Fas signaling pathway GO:1902044
Any process that modulates the frequency, rate or extent of Fas signaling pathway.
|
3 | Q9N1Q5 (/ISS) Q9N1Q6 (/ISS) Q9N1Q7 (/ISS) |
|
Inflammatory response to antigenic stimulus GO:0002437
An inflammatory response to an antigenic stimulus, which can be include any number of T cell or B cell epitopes.
|
2 | P30681 (/IMP) Q3U566 (/IMP) |
|
Nucleosome assembly GO:0006334
The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA.
|
2 | F1RJ01 (/IDA) P17741 (/IDA) |
|
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
|
2 | F1RJ01 (/ISS) P17741 (/ISS) |
|
Spermatid nucleus differentiation GO:0007289
The specialization of the spermatid nucleus during the development of a spermatid into a mature male gamete competent for fertilization.
|
2 | F1RJ01 (/ISS) P17741 (/ISS) |
|
Male gonad development GO:0008584
The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure.
|
2 | F1RJ01 (/ISS) P17741 (/ISS) |
|
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
2 | P30681 (/IDA) Q3U566 (/IDA) |
|
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
2 | P30681 (/IDA) Q3U566 (/IDA) |
|
DNA geometric change GO:0032392
The process in which a transformation is induced in the geometry of a DNA double helix, resulting in a change in twist, writhe, or both, but with no change in linking number. Includes the unwinding of double-stranded DNA by helicases.
|
2 | F1NPU8 (/IDA) P26584 (/IDA) |
|
Response to lipopolysaccharide GO:0032496
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
|
2 | P30681 (/IMP) Q3U566 (/IMP) |
|
Positive regulation of DNA binding GO:0043388
Any process that increases the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid).
|
2 | F1RJ01 (/ISS) P17741 (/ISS) |
|
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
2 | P23497 (/IMP) P52925 (/IMP) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
2 | F1RJ01 (/ISS) P17741 (/ISS) |
|
Response to steroid hormone GO:0048545
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus.
|
2 | F1RJ01 (/ISS) P17741 (/ISS) |
|
Regulation of neurogenesis GO:0050767
Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system.
|
2 | P30681 (/IMP) Q3U566 (/IMP) |
|
DNA ligation involved in DNA repair GO:0051103
The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase, that contributes to DNA repair.
|
2 | F1RJ01 (/IDA) P17741 (/IDA) |
|
Regulation of stem cell proliferation GO:0072091
Any process that modulates the frequency, rate or extent of stem cell proliferation. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.
|
2 | P30681 (/IMP) Q3U566 (/IMP) |
|
Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042
Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors.
|
2 | F1RJ01 (/ISS) P17741 (/ISS) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
1 | P23497 (/IDA) |
|
Telomere maintenance GO:0000723
Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences.
|
1 | P23497 (/IMP) |
|
Positive regulation of endothelial cell proliferation GO:0001938
Any process that activates or increases the rate or extent of endothelial cell proliferation.
|
1 | P30681 (/ISO) |
|
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
1 | P30681 (/ISO) |
|
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978
A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, resulting in the induction of the transcription of p21 (also known as WAF1, CIP1 and SDI1) or any equivalent protein, in response to the detection of DNA damage.
|
1 | P23497 (/IDA) |
|
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
|
1 | P30681 (/IMP) |
|
Spermatid nucleus differentiation GO:0007289
The specialization of the spermatid nucleus during the development of a spermatid into a mature male gamete competent for fertilization.
|
1 | P30681 (/IMP) |
|
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
|
1 | P52925 (/IDA) |
|
Male gonad development GO:0008584
The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure.
|
1 | P30681 (/IMP) |
|
Negative regulation of endothelial cell migration GO:0010596
Any process that decreases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.
|
1 | P23497 (/IMP) |
|
Animal organ regeneration GO:0031100
The regrowth of a lost or destroyed animal organ.
|
1 | P52925 (/IEP) |
|
Positive regulation of nuclease activity GO:0032075
Any process that activates or increases the frequency, rate or extent of nuclease activity, the hydrolysis of ester linkages within nucleic acids.
|
1 | P30681 (/ISO) |
|
Positive regulation of interferon-beta production GO:0032728
Any process that activates or increases the frequency, rate, or extent of interferon-beta production.
|
1 | P30681 (/IMP) |
|
Response to type I interferon GO:0034340
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type I interferon stimulus. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
|
1 | P23497 (/IDA) |
|
Response to type I interferon GO:0034340
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type I interferon stimulus. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
|
1 | P23497 (/IMP) |
|
Response to interferon-gamma GO:0034341
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon-gamma is also known as type II interferon.
|
1 | P23497 (/IDA) |
|
Response to interferon-gamma GO:0034341
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon-gamma is also known as type II interferon.
|
1 | P23497 (/IMP) |
|
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
|
1 | Q3U566 (/IDA) |
|
Positive regulation of DNA binding GO:0043388
Any process that increases the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid).
|
1 | P30681 (/ISO) |
|
Negative regulation of DNA binding GO:0043392
Any process that stops or reduces the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid).
|
1 | P23497 (/IDA) |
|
Negative regulation of DNA-binding transcription factor activity GO:0043433
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
|
1 | P23497 (/IDA) |
|
Positive regulation of innate immune response GO:0045089
Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection.
|
1 | P30681 (/IMP) |
|
Maintenance of protein location GO:0045185
Any process in which a protein is maintained in a location and prevented from moving elsewhere. These include sequestration, stabilization to prevent transport elsewhere and the active retrieval of proteins that do move away.
|
1 | P23497 (/IDA) |
|
Positive regulation of erythrocyte differentiation GO:0045648
Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation.
|
1 | P30681 (/ISO) |
|
Positive regulation of megakaryocyte differentiation GO:0045654
Any process that activates or increases the frequency, rate or extent of megakaryocyte differentiation.
|
1 | P30681 (/ISO) |
|
Regulation of angiogenesis GO:0045765
Any process that modulates the frequency, rate or extent of angiogenesis.
|
1 | P23497 (/IMP) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | P30681 (/ISO) |
|
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | P30681 (/ISO) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
1 | P30681 (/IMP) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
1 | P30681 (/ISO) |
|
Negative regulation of protein export from nucleus GO:0046826
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of proteins from the nucleus into the cytoplasm.
|
1 | P23497 (/IMP) |
|
Response to steroid hormone GO:0048545
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus.
|
1 | P30681 (/IMP) |
|
Defense response to Gram-negative bacterium GO:0050829
Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.
|
1 | P30681 (/ISO) |
|
Defense response to Gram-positive bacterium GO:0050830
Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism.
|
1 | P30681 (/ISO) |
|
Positive regulation of DNA metabolic process GO:0051054
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA.
|
1 | P52925 (/IMP) |
|
Negative regulation of cellular component movement GO:0051271
Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of a cellular component.
|
1 | P23497 (/IMP) |
|
Cell chemotaxis GO:0060326
The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
|
1 | P30681 (/ISO) |
|
Interferon-gamma-mediated signaling pathway GO:0060333
A series of molecular signals initiated by the binding of interferon-gamma to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Interferon gamma is the only member of the type II interferon found so far.
|
1 | P23497 (/IC) |
|
Interferon-gamma-mediated signaling pathway GO:0060333
A series of molecular signals initiated by the binding of interferon-gamma to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Interferon gamma is the only member of the type II interferon found so far.
|
1 | P23497 (/TAS) |
|
Type I interferon signaling pathway GO:0060337
A series of molecular signals initiated by the binding of a type I interferon to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
|
1 | P23497 (/IC) |
|
Regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041
Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors.
|
1 | P23497 (/IMP) |
|
Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042
Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors.
|
1 | P30681 (/IMP) |
|
Regulation of Fas signaling pathway GO:1902044
Any process that modulates the frequency, rate or extent of Fas signaling pathway.
|
1 | P23497 (/IMP) |
There are 30 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
195 |
A0A087QNV0 (/ISS)
A0A087QNV0 (/ISS)
A0A087QNV0 (/ISS)
A0A087QNV0 (/ISS)
A0A091F7A2 (/ISS)
A0A091GCL3 (/ISS)
A0A091GCL3 (/ISS)
A0A091H0T5 (/ISS)
A0A091IH21 (/ISS)
A0A091KT98 (/ISS)
(185 more) |
|
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
191 |
A0A087QNV0 (/ISS)
A0A087QNV0 (/ISS)
A0A087QNV0 (/ISS)
A0A087QNV0 (/ISS)
A0A091F7A2 (/ISS)
A0A091GCL3 (/ISS)
A0A091GCL3 (/ISS)
A0A091H0T5 (/ISS)
A0A091IH21 (/ISS)
A0A091KT98 (/ISS)
(181 more) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
191 |
A0A087QNV0 (/ISS)
A0A087QNV0 (/ISS)
A0A087QNV0 (/ISS)
A0A087QNV0 (/ISS)
A0A091F7A2 (/ISS)
A0A091GCL3 (/ISS)
A0A091GCL3 (/ISS)
A0A091H0T5 (/ISS)
A0A091IH21 (/ISS)
A0A091KT98 (/ISS)
(181 more) |
|
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
|
178 |
A0A091GCL3 (/ISS)
A0A091GCL3 (/ISS)
A0A091H0T5 (/ISS)
A0A091KT98 (/ISS)
A0A091KT98 (/ISS)
A0A091PGF7 (/ISS)
A0A091PGF7 (/ISS)
A0A091PGF7 (/ISS)
A0A093RXY1 (/ISS)
A0A093RXY1 (/ISS)
(168 more) |
|
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
|
16 |
F1RJ01 (/ISS)
P17741 (/ISS)
P26584 (/ISS)
P30681 (/ISS)
P40673 (/ISS)
P40673 (/ISS)
P40673 (/ISS)
P40673 (/ISS)
P40673 (/ISS)
P40673 (/ISS)
(6 more) |
|
Condensed chromosome GO:0000793
A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure.
|
15 |
P17741 (/ISS)
P26584 (/ISS)
P30681 (/ISS)
P40673 (/ISS)
P40673 (/ISS)
P40673 (/ISS)
P40673 (/ISS)
P40673 (/ISS)
P40673 (/ISS)
P40673 (/ISS)
(5 more) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
15 |
P23497 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
(5 more) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
14 |
P23497 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
(4 more) |
|
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
13 |
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
(3 more) |
|
Cell GO:0005623
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
|
13 |
F1RJ01 (/IDA)
P17741 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
(3 more) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
12 |
P23497 (/TAS)
P26583 (/TAS)
P26583 (/TAS)
P26583 (/TAS)
P26583 (/TAS)
P26583 (/TAS)
P26583 (/TAS)
P26583 (/TAS)
P26583 (/TAS)
P26583 (/TAS)
(2 more) |
|
Condensed chromosome GO:0000793
A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure.
|
11 |
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
(1 more) |
|
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
|
11 |
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
(1 more) |
|
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
|
11 |
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
(1 more) |
|
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
|
11 |
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
P26583 (/IDA)
(1 more) |
|
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
|
4 | F1RJ01 (/IDA) P17741 (/IDA) P30681 (/IDA) Q3U566 (/IDA) |
|
PML body GO:0016605
A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection.
|
3 | Q9N1Q5 (/ISS) Q9N1Q6 (/ISS) Q9N1Q7 (/ISS) |
|
Cell GO:0005623
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
|
2 | F1RJ01 (/ISS) P17741 (/ISS) |
|
Nuclear chromosome, telomeric region GO:0000784
The terminal region of a linear nuclear chromosome that includes the telomeric DNA repeats and associated proteins.
|
1 | P23497 (/HDA) |
|
Condensed chromosome GO:0000793
A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure.
|
1 | P30681 (/ISO) |
|
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
1 | P30681 (/ISO) |
|
Cell GO:0005623
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
|
1 | P30681 (/ISO) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | P30681 (/IC) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | P30681 (/ISO) |
|
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
|
1 | P30681 (/ISO) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | P30681 (/ISO) |
|
Nuclear body GO:0016604
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
|
1 | P23497 (/IDA) |
|
PML body GO:0016605
A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection.
|
1 | P23497 (/IDA) |
|
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
|
1 | P30681 (/ISO) |
|
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
|
1 | P30681 (/ISO) |