The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
5' to 3' exonuclease, C-terminal subdomain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 32: meiotic recombination protein DMC1/LIM15 homolog

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 17 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
10 O42634 (/IPI) Q14565 (/IPI) Q14565 (/IPI) Q14565 (/IPI) Q14565 (/IPI) Q14565 (/IPI) Q14565 (/IPI) Q14565 (/IPI) Q14565 (/IPI) Q14565 (/IPI)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
9 Q14565 (/TAS) Q14565 (/TAS) Q14565 (/TAS) Q14565 (/TAS) Q14565 (/TAS) Q14565 (/TAS) Q14565 (/TAS) Q14565 (/TAS) Q14565 (/TAS)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
9 Q14565 (/TAS) Q14565 (/TAS) Q14565 (/TAS) Q14565 (/TAS) Q14565 (/TAS) Q14565 (/TAS) Q14565 (/TAS) Q14565 (/TAS) Q14565 (/TAS)
Recombinase activity GO:0000150
Catalysis of the identification and base-pairing of homologous sequences between single-stranded DNA and double-stranded DNA.
8 Q14AN8 (/ISS) Q14AN8 (/ISS) Q50LF6 (/ISS) Q50LF7 (/ISS) Q61880 (/ISS) Q61880 (/ISS) Q9DGC3 (/ISS) Q9GRA3 (/ISS)
Double-stranded DNA binding GO:0003690
Interacting selectively and non-covalently with double-stranded DNA.
8 Q14AN8 (/ISS) Q14AN8 (/ISS) Q50LF6 (/ISS) Q50LF7 (/ISS) Q61880 (/ISS) Q61880 (/ISS) Q9DGC3 (/ISS) Q9GRA3 (/ISS)
Single-stranded DNA binding GO:0003697
Interacting selectively and non-covalently with single-stranded DNA.
8 Q14AN8 (/ISS) Q14AN8 (/ISS) Q50LF6 (/ISS) Q50LF7 (/ISS) Q61880 (/ISS) Q61880 (/ISS) Q9DGC3 (/ISS) Q9GRA3 (/ISS)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
8 Q14AN8 (/ISS) Q14AN8 (/ISS) Q50LF6 (/ISS) Q50LF7 (/ISS) Q61880 (/ISS) Q61880 (/ISS) Q9DGC3 (/ISS) Q9GRA3 (/ISS)
ATPase activity GO:0016887
Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
8 Q14AN8 (/ISS) Q14AN8 (/ISS) Q50LF6 (/ISS) Q50LF7 (/ISS) Q61880 (/ISS) Q61880 (/ISS) Q9DGC3 (/ISS) Q9GRA3 (/ISS)
Recombinase activity GO:0000150
Catalysis of the identification and base-pairing of homologous sequences between single-stranded DNA and double-stranded DNA.
1 O42634 (/IDA)
Double-stranded DNA binding GO:0003690
Interacting selectively and non-covalently with double-stranded DNA.
1 O42634 (/IDA)
Single-stranded DNA binding GO:0003697
Interacting selectively and non-covalently with single-stranded DNA.
1 O42634 (/IDA)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
1 O42634 (/IDA)
DNA-dependent ATPase activity GO:0008094
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of single- or double-stranded DNA, and it drives another reaction.
1 O42634 (/IDA)
ATPase activity GO:0016887
Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
1 O42634 (/IDA)
Single-stranded DNA helicase activity GO:0017116
Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of a DNA helix.
1 O42634 (/IDA)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 O42634 (/IPI)
Swi5-Sfr1 complex binding GO:1905334
Interacting selectively and non-covalently with a Swi5-Sfr1 complex.
1 O42634 (/IPI)

There are 18 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Reciprocal meiotic recombination GO:0007131
The cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity.
9 Q14565 (/TAS) Q14565 (/TAS) Q14565 (/TAS) Q14565 (/TAS) Q14565 (/TAS) Q14565 (/TAS) Q14565 (/TAS) Q14565 (/TAS) Q14565 (/TAS)
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
9 Q14565 (/TAS) Q14565 (/TAS) Q14565 (/TAS) Q14565 (/TAS) Q14565 (/TAS) Q14565 (/TAS) Q14565 (/TAS) Q14565 (/TAS) Q14565 (/TAS)
Female gamete generation GO:0007292
Generation of the female gamete; specialised haploid cells produced by meiosis and along with a male gamete takes part in sexual reproduction.
9 Q14565 (/TAS) Q14565 (/TAS) Q14565 (/TAS) Q14565 (/TAS) Q14565 (/TAS) Q14565 (/TAS) Q14565 (/TAS) Q14565 (/TAS) Q14565 (/TAS)
Meiotic cell cycle GO:0051321
Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions.
9 Q14565 (/TAS) Q14565 (/TAS) Q14565 (/TAS) Q14565 (/TAS) Q14565 (/TAS) Q14565 (/TAS) Q14565 (/TAS) Q14565 (/TAS) Q14565 (/TAS)
Ovarian follicle development GO:0001541
The process whose specific outcome is the progression of the ovarian follicle over time, from its formation to the mature structure.
2 Q61880 (/IMP) Q61880 (/IMP)
Oocyte maturation GO:0001556
A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization.
2 Q61880 (/IMP) Q61880 (/IMP)
Synapsis GO:0007129
The meiotic cell cycle process where side by side pairing and physical juxtaposition of homologous chromosomes is created during meiotic prophase. Synapsis begins when the chromosome arms begin to pair from the clustered telomeres and ends when synaptonemal complex or linear element assembly is complete.
2 Q61880 (/IMP) Q61880 (/IMP)
Male meiosis I GO:0007141
A cell cycle process comprising the steps by which a cell progresses through male meiosis I, the first meiotic division in the male germline.
2 Q61880 (/IMP) Q61880 (/IMP)
Gamete generation GO:0007276
The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell.
2 Q61880 (/IMP) Q61880 (/IMP)
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
2 Q61880 (/IMP) Q61880 (/IMP)
Spermatid development GO:0007286
The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure.
2 Q61880 (/IMP) Q61880 (/IMP)
Meiotic joint molecule formation GO:0000709
The conversion of the paired broken DNA and homologous duplex DNA into a four-stranded branched intermediate, known as a joint molecule, formed during meiotic recombination. These joint molecules contain Holliday junctions on either side of heteroduplex DNA.
1 O42634 (/IDA)
Meiotic gene conversion GO:0006311
The cell cycle process in which genetic information is transferred from one helix to another. It often occurs in association with general genetic recombination events, and is believed to be a straightforward consequence of the mechanisms of general recombination and DNA repair. For example, meiosis might yield three copies of the maternal version of an allele and only one copy of the paternal allele, indicating that one of the two copies of the paternal allele has been changed to a copy of the maternal allele.
1 O42634 (/IMP)
Reciprocal meiotic recombination GO:0007131
The cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity.
1 O42634 (/IMP)
Regulation of reciprocal meiotic recombination GO:0010520
Any process that modulates the frequency, rate or extent of recombination during meiosis. Reciprocal meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate.
1 O42634 (/IGI)
Regulation of reciprocal meiotic recombination GO:0010520
Any process that modulates the frequency, rate or extent of recombination during meiosis. Reciprocal meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate.
1 O42634 (/IMP)
Strand invasion GO:0042148
The process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules.
1 O42634 (/IDA)
Protein homooligomerization GO:0051260
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
1 O42634 (/IPI)

There are 11 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
11 Q14565 (/IDA) Q14565 (/IDA) Q14565 (/IDA) Q14565 (/IDA) Q14565 (/IDA) Q14565 (/IDA) Q14565 (/IDA) Q14565 (/IDA) Q14565 (/IDA) Q61880 (/IDA)
(1 more)
Condensed nuclear chromosome GO:0000794
A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct nuclear chromosome.
9 Q14565 (/TAS) Q14565 (/TAS) Q14565 (/TAS) Q14565 (/TAS) Q14565 (/TAS) Q14565 (/TAS) Q14565 (/TAS) Q14565 (/TAS) Q14565 (/TAS)
Chromosome GO:0005694
A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
9 Q14565 (/ISS) Q14565 (/ISS) Q14565 (/ISS) Q14565 (/ISS) Q14565 (/ISS) Q14565 (/ISS) Q14565 (/ISS) Q14565 (/ISS) Q14565 (/ISS)
Chromosome, telomeric region GO:0000781
The terminal region of a linear chromosome that includes the telomeric DNA repeats and associated proteins.
2 Q61880 (/IDA) Q61880 (/IDA)
Condensed nuclear chromosome GO:0000794
A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct nuclear chromosome.
2 Q61880 (/IDA) Q61880 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 Q61880 (/ISO) Q61880 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 Q61880 (/TAS) Q61880 (/TAS)
Chromosome GO:0005694
A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
2 Q61880 (/IDA) Q61880 (/IDA)
Condensed nuclear chromosome GO:0000794
A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct nuclear chromosome.
1 O42634 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 O42634 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 O42634 (/HDA)