The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"5' to 3' exonuclease, C-terminal subdomain
".
FunFam 19: DNA polymerase IV
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 3 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
DNA-directed DNA polymerase activity GO:0003887
Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group.
|
31 |
Q47155 (/IDA)
Q47155 (/IDA)
Q47155 (/IDA)
Q47155 (/IDA)
Q47155 (/IDA)
Q47155 (/IDA)
Q47155 (/IDA)
Q47155 (/IDA)
Q47155 (/IDA)
Q47155 (/IDA)
(21 more) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
31 |
Q47155 (/IPI)
Q47155 (/IPI)
Q47155 (/IPI)
Q47155 (/IPI)
Q47155 (/IPI)
Q47155 (/IPI)
Q47155 (/IPI)
Q47155 (/IPI)
Q47155 (/IPI)
Q47155 (/IPI)
(21 more) |
|
DNA-directed DNA polymerase activity GO:0003887
Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group.
|
3 | Q48FB2 (/ISS) Q48FB2 (/ISS) Q87Y22 (/ISS) |
There are 8 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
DNA synthesis involved in DNA repair GO:0000731
Synthesis of DNA that proceeds from the broken 3' single-strand DNA end and uses the homologous intact duplex as the template.
|
31 |
Q47155 (/IDA)
Q47155 (/IDA)
Q47155 (/IDA)
Q47155 (/IDA)
Q47155 (/IDA)
Q47155 (/IDA)
Q47155 (/IDA)
Q47155 (/IDA)
Q47155 (/IDA)
Q47155 (/IDA)
(21 more) |
|
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
|
31 |
Q47155 (/IEP)
Q47155 (/IEP)
Q47155 (/IEP)
Q47155 (/IEP)
Q47155 (/IEP)
Q47155 (/IEP)
Q47155 (/IEP)
Q47155 (/IEP)
Q47155 (/IEP)
Q47155 (/IEP)
(21 more) |
|
SOS response GO:0009432
An error-prone process for repairing damaged microbial DNA.
|
31 |
Q47155 (/IDA)
Q47155 (/IDA)
Q47155 (/IDA)
Q47155 (/IDA)
Q47155 (/IDA)
Q47155 (/IDA)
Q47155 (/IDA)
Q47155 (/IDA)
Q47155 (/IDA)
Q47155 (/IDA)
(21 more) |
|
SOS response GO:0009432
An error-prone process for repairing damaged microbial DNA.
|
31 |
Q47155 (/IEP)
Q47155 (/IEP)
Q47155 (/IEP)
Q47155 (/IEP)
Q47155 (/IEP)
Q47155 (/IEP)
Q47155 (/IEP)
Q47155 (/IEP)
Q47155 (/IEP)
Q47155 (/IEP)
(21 more) |
|
Translesion synthesis GO:0019985
The replication of damaged DNA by synthesis across a lesion in the template strand; a specialized DNA polymerase or replication complex inserts a defined nucleotide across from the lesion which allows DNA synthesis to continue beyond the lesion. This process can be mutagenic depending on the damaged nucleotide and the inserted nucleotide.
|
31 |
Q47155 (/IDA)
Q47155 (/IDA)
Q47155 (/IDA)
Q47155 (/IDA)
Q47155 (/IDA)
Q47155 (/IDA)
Q47155 (/IDA)
Q47155 (/IDA)
Q47155 (/IDA)
Q47155 (/IDA)
(21 more) |
|
SOS response GO:0009432
An error-prone process for repairing damaged microbial DNA.
|
8 | Q72MY7 (/EXP) Q72MY7 (/EXP) Q72MY7 (/EXP) Q72MY7 (/EXP) Q72MY7 (/EXP) Q72MY7 (/EXP) Q72MY7 (/EXP) Q72MY7 (/EXP) |
|
DNA replication GO:0006260
The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
|
3 | Q48FB2 (/ISS) Q48FB2 (/ISS) Q87Y22 (/ISS) |
|
DNA repair GO:0006281
The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
|
3 | Q48FB2 (/ISS) Q48FB2 (/ISS) Q87Y22 (/ISS) |
There are 1 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
31 |
Q47155 (/IDA)
Q47155 (/IDA)
Q47155 (/IDA)
Q47155 (/IDA)
Q47155 (/IDA)
Q47155 (/IDA)
Q47155 (/IDA)
Q47155 (/IDA)
Q47155 (/IDA)
Q47155 (/IDA)
(21 more) |