The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 7: Phosphodiesterase 10A

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 13 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
CGMP-stimulated cyclic-nucleotide phosphodiesterase activity GO:0004118
Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is increased in the presence of cGMP.
10 F1MPW5 (/ISS) F1PLV5 (/ISS) F1SBW6 (/ISS) F6QYL3 (/ISS) F6URL1 (/ISS) F6ZRI6 (/ISS) F7HBA5 (/ISS) F7IPQ1 (/ISS) Q8CA95 (/ISS) Q9QYJ6 (/ISS)
CAMP binding GO:0030552
Interacting selectively and non-covalently with cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate).
9 F1MPW5 (/ISS) F1PLV5 (/ISS) F1SBW6 (/ISS) F6QYL3 (/ISS) F6URL1 (/ISS) F6ZRI6 (/ISS) F7HBA5 (/ISS) F7IPQ1 (/ISS) Q8CA95 (/ISS)
3',5'-cyclic-nucleotide phosphodiesterase activity GO:0004114
Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate.
3 Q9Y233 (/TAS) Q9Y233 (/TAS) Q9Y233 (/TAS)
CGMP-stimulated cyclic-nucleotide phosphodiesterase activity GO:0004118
Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is increased in the presence of cGMP.
3 Q9Y233 (/IDA) Q9Y233 (/IDA) Q9Y233 (/IDA)
CAMP binding GO:0030552
Interacting selectively and non-covalently with cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate).
3 Q9Y233 (/IDA) Q9Y233 (/IDA) Q9Y233 (/IDA)
CAMP binding GO:0030552
Interacting selectively and non-covalently with cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate).
3 Q9Y233 (/NAS) Q9Y233 (/NAS) Q9Y233 (/NAS)
CGMP binding GO:0030553
Interacting selectively and non-covalently with cGMP, the nucleotide cyclic GMP (guanosine 3',5'-cyclophosphate).
3 Q9Y233 (/NAS) Q9Y233 (/NAS) Q9Y233 (/NAS)
Cyclic-nucleotide phosphodiesterase activity GO:0004112
Catalysis of the reaction: a nucleoside cyclic phosphate + H2O = a nucleoside phosphate.
1 Q9QYJ6 (/IDA)
Cyclic-nucleotide phosphodiesterase activity GO:0004112
Catalysis of the reaction: a nucleoside cyclic phosphate + H2O = a nucleoside phosphate.
1 Q8CA95 (/ISO)
3',5'-cyclic-nucleotide phosphodiesterase activity GO:0004114
Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate.
1 Q8CA95 (/IDA)
3',5'-cyclic-nucleotide phosphodiesterase activity GO:0004114
Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate.
1 Q8CA95 (/IMP)
CGMP-stimulated cyclic-nucleotide phosphodiesterase activity GO:0004118
Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is increased in the presence of cGMP.
1 Q8CA95 (/ISO)
CAMP binding GO:0030552
Interacting selectively and non-covalently with cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate).
1 Q8CA95 (/ISO)

There are 7 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
3 Q9Y233 (/TAS) Q9Y233 (/TAS) Q9Y233 (/TAS)
Regulation of protein kinase A signaling GO:0010738
Any process that modulates the rate, frequency, or extent of protein kinase A signaling. PKA signaling is the series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound.
1 Q8CA95 (/IMP)
Negative regulation of cGMP-mediated signaling GO:0010754
Any process that decreases the rate, frequency or extent of cGMP-mediated signaling. cGMP-mediated signaling is a series of molecular signals in which a cell uses cyclic GMP to convert an extracellular signal into a response.
1 Q9QYJ6 (/IDA)
Negative regulation of cGMP-mediated signaling GO:0010754
Any process that decreases the rate, frequency or extent of cGMP-mediated signaling. cGMP-mediated signaling is a series of molecular signals in which a cell uses cyclic GMP to convert an extracellular signal into a response.
1 Q8CA95 (/ISO)
Regulation of cAMP-mediated signaling GO:0043949
Any process which modulates the frequency, rate or extent of cAMP-mediated signaling, a series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response.
1 Q8CA95 (/IMP)
Negative regulation of cAMP-mediated signaling GO:0043951
Any process which stops, prevents, or reduces the frequency, rate or extent of cAMP-mediated signaling, a series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response.
1 Q9QYJ6 (/IDA)
Negative regulation of cAMP-mediated signaling GO:0043951
Any process which stops, prevents, or reduces the frequency, rate or extent of cAMP-mediated signaling, a series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response.
1 Q8CA95 (/ISO)

There are 7 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 Q9Y233 (/TAS) Q9Y233 (/TAS) Q9Y233 (/TAS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q9QYJ6 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q8CA95 (/ISO)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 Q9QYJ6 (/IDA)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 Q8CA95 (/ISO)
Perikaryon GO:0043204
The portion of the cell soma (neuronal cell body) that excludes the nucleus.
1 Q9QYJ6 (/IDA)
Perikaryon GO:0043204
The portion of the cell soma (neuronal cell body) that excludes the nucleus.
1 Q8CA95 (/ISO)