CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
Functional Family TANK binding kinase TBK1

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt Q9UHD2
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

Q9UHD2
TBK1_HUMAN
Homo sapiens
Serine/threonine-protein kinase TBK1

PDB Structure

PDB 6O8B
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1.
Zhao, B., Du, F., Xu, P., Shu, C., Sankaran, B., Bell, S.L., Liu, M., Lei, Y., Gao, X., Fu, X., Zhu, F., Liu, Y., Laganowsky, A., Zheng, X., Ji, J.Y., West, A.P., Watson, R.O., Li, P.
Nature