Homologous Superfamily: 3.10.20.90

Molscript image for 3a4rA00
Representative domain: 3a4rA00
PDB coordinates for domain 3a4rA00

Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1

Classification Lineage (3.10.20.90)

CATH CodeLevel DescriptionLinks
3 Alpha Beta
3.10 Roll
3.10.20 Ubiquitin-like (UB roll)
3.10.20.90 Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1 Gene3D

Summary of Non-Redundant Representatives
- - - - 47 62 90 142 454

S35 Family Entries in Homologous Superfamily 3.10.20.90 (47)

CATH Level CATH code Representative Domain Representative Keywords Representative Thumbnail Number of Domains
3.10.20.90.1 3a4rA00 Mus musculusNFATC2-interacting proteinRegulation of transcription, DNA-dependentCytokine production Molscript image for 3a4rA00 5
3.10.20.90.2 2gbjB00 Molscript image for 2gbjB00 233
3.10.20.90.3 2bwfA00 Ubiquitin domain-containing protein DSK2Protein binding, bridgingSpindle pole body duplication in nuclear envelopeSaccharomyces cerevisiaeER-associated protein catabolic process Molscript image for 2bwfA00 5
3.10.20.90.4 1wm3A00 Small ubiquitin-related modifierHomo sapiensProtein sumoylationSmall ubiquitin-related modifier 2Protein binding Molscript image for 1wm3A00 5
3.10.20.90.5 2zeqA00 LearningSynaptic transmission, glutamatergicAdult locomotory behaviorParkinson's diseaseDopamine metabolic process Molscript image for 2zeqA00 4
3.10.20.90.6 1h4rA01 Negative regulation of cell-cell adhesionSchwann cell proliferationCytoskeletonNucleolusEarly endosome Molscript image for 1h4rA01 29
3.10.20.90.7 2v3sA00 Non-specific serine/threonine protein kinase.Identical protein bindingSerine/threonine-protein kinase OSR1Oxidative-stress responsive protein 1 [EC:2.7.11.1]ATP binding Molscript image for 2v3sA00 2
3.10.20.90.8 1lfdA00 Rattus norvegicusRal guanine nucleotide dissociation stimulatorSmall GTPase mediated signal transduction Molscript image for 1lfdA00 9
3.10.20.90.9 2he7A01 Tight junctionErythrocyte membrane protein band 4.1Homo sapiensBand 4.1-like protein 3Cell-cell junction Molscript image for 2he7A01 5
3.10.20.90.10 1c1yB00 RAF proto-oncogene serine/threonine-protein kinaseNeurotrophin signaling pathwayNon-small cell lung cancerProtein bindingT cell receptor signaling pathway Molscript image for 1c1yB00 6
3.10.20.90.11 2fnjB00 Renal cell carcinomaMus musculusPathways in cancerTranscription elongation factor B polypeptide 2Ubiquitin mediated proteolysis Molscript image for 2fnjB00 11
3.10.20.90.12 1oeyA00 Protein C-terminus bindingNeutrophil cytosol factor 2Leukocyte transendothelial migrationCellular defense responseSuperoxide anion generation Molscript image for 1oeyA00 4
3.10.20.90.13 2fazA00 E3 ubiquitin-protein ligase UHRF1RNA polymerase II transcription factor activityAcid--D-amino-acid ligases (peptide synthases).Protein bindingCell proliferation Molscript image for 2fazA00 2
3.10.20.90.14 1wywB00 Nuclear poreNegative regulation of transcriptionSmall ubiquitin-related modifier 1Protein bindingProtein sumoylation Molscript image for 1wywB00 23
3.10.20.90.15 3d32B00 Synaptic transmissionPlasma membraneProtein targetingGamma-aminobutyric acid receptor-associated proteinBeta-tubulin binding Molscript image for 3d32B00 20
3.10.20.90.16 2r2oA00 Semaphorin receptor bindingPlexin BSemaphorin receptor activityPlexin-B1Homo sapiens Molscript image for 2r2oA00 4
3.10.20.90.17 1yqbA01 Ubiquilin-3Homo sapiensUbiquilin Molscript image for 1yqbA01 3
3.10.20.90.18 3kh0A00 Ral guanine nucleotide dissociation stimulatorSmall GTPase regulator activityHomo sapiens Molscript image for 3kh0A00 2
3.10.20.90.19 1y8rC00 Nuclear poreNegative regulation of transcriptionSmall ubiquitin-related modifier 1Protein bindingProtein sumoylation Molscript image for 1y8rC00 3
3.10.20.90.20 1z2mA02 RIG-I-like receptor signaling pathwayInterferon-induced 17 kDa proteinISG15-protein conjugationHomo sapiensUbiquitin cross-reactive protein Molscript image for 1z2mA02 2
3.10.20.90.21 1z2mA01 RIG-I-like receptor signaling pathwayInterferon-induced 17 kDa proteinISG15-protein conjugationHomo sapiensUbiquitin cross-reactive protein Molscript image for 1z2mA01 2
3.10.20.90.22 2zjdA00 Homo sapiensMicrotubule-associated protein 1 light chainMicrotubule-associated proteins 1A/1B light chain 3BProtein binding Molscript image for 2zjdA00 10
3.10.20.90.23 1k8rB00 Plasma membraneInduction of conjugation upon nitrogen starvationProtein bindingSchizosaccharomyces pombeCytoplasm Molscript image for 1k8rB00 2
3.10.20.90.24 2rd0A01 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoformJak-STAT signaling pathwayPhosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]Aldosterone-regulated sodium reabsorptionNeurotrophin signaling pathway Molscript image for 2rd0A01 1
3.10.20.90.25 1s3sH00 Rattus norvegicusGolgi organizationCellular membrane fusionNSFL1 cofactor p47Protein binding Molscript image for 1s3sH00 2
3.10.20.90.26 1e8yA01 Jak-STAT signaling pathwayPhosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]Aldosterone-regulated sodium reabsorptionNeurotrophin signaling pathwayNon-small cell lung cancer Molscript image for 1e8yA01 24
3.10.20.90.27 2rd0A02 Jak-STAT signaling pathwayPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoformPhosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]Aldosterone-regulated sodium reabsorptionNeurotrophin signaling pathway Molscript image for 2rd0A02 1
3.10.20.90.28 1wx9A00 Large proline-rich protein BAT3Homo sapiensProtein binding Molscript image for 1wx9A00 2
3.10.20.90.29 1p1aA00 UV excision repair protein RAD23 homolog BNucleotide excision repairSingle-stranded DNA bindingHomo sapiensUV excision repair protein RAD23 Molscript image for 1p1aA00 2
3.10.20.90.30 1wxsA00 CytoplasmUbiquitin-fold modifier 1Protein ufmylationNucleusHomo sapiens Molscript image for 1wxsA00 3
3.10.20.90.31 1i42A00 Rattus norvegicusGolgi organizationCellular membrane fusionNSFL1 cofactor p47Protein binding Molscript image for 1i42A00 2
3.10.20.90.32 1h8cA00 Cytoplasmic sequestering of NF-kappaBHeat shock protein bindingFAS-associated factor 1CytosolPositive regulation of protein complex assembly Molscript image for 1h8cA00 1
3.10.20.90.33 1t0yA00 Caenorhabditis elegansTubulin-specific chaperone B Molscript image for 1t0yA00 1
3.10.20.90.34 1v5tA00 Mus musculusUbiquitin-like domain-containing CTD phosphatase 1Phosphoprotein phosphatase.Protein phosphatase [EC:3.1.3.16] Molscript image for 1v5tA00 2
3.10.20.90.35 1oqyA01 Nucleotide excision repairNucleotide-excision repairSingle-stranded DNA bindingUV excision repair protein RAD23 homolog AHomo sapiens Molscript image for 1oqyA01 4
3.10.20.90.36 1wgdA00 Endoplasmic reticulum membraneHomocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 proteinHomo sapiensProtein binding Molscript image for 1wgdA00 2
3.10.20.90.37 1v86A00 Mus musculusPutative uncharacterized protein Molscript image for 1v86A00 1
3.10.20.90.38 1m94A00 Mating projectionProtein tagUbiquitin-like modifier HUB1Ubiquitin-like protein 5Cell morphogenesis involved in conjugation with cellular fusion Molscript image for 1m94A00 2
3.10.20.90.39 1uh6A00 Mus musculusUbiquitin-like protein 5Ubiquitin-like protein 5 Molscript image for 1uh6A00 3
3.10.20.90.40 1wh3A01 CytoplasmDNA bindingThyroid hormone receptor binding59 kDa 2'-5'-oligoadenylate synthase-like proteinNucleolus Molscript image for 1wh3A01 1
3.10.20.90.41 1wxmA01 Non-specific serine/threonine protein kinase.Bladder cancerPathways in cancerNon-small cell lung cancerAcute myeloid leukemia Molscript image for 1wxmA01 2
3.10.20.90.42 2kd0A01 LRR repeats and ubiquitin-like domain-containing protein At2g30105Arabidopsis thaliana Molscript image for 2kd0A01 1
3.10.20.90.43 1se9A00 Membrane-anchored ubiquitin-fold protein 1Arabidopsis thaliana Molscript image for 1se9A00 1
3.10.20.90.44 1v5oA00 Mus musculusDNA damage-inducible protein 1Protein DDI1 homolog 1 Molscript image for 1v5oA00 1
3.10.20.90.45 1j8cA00 CytoplasmPlasma membraneHomo sapiensUbiquilinUbiquilin-2 Molscript image for 1j8cA00 1
3.10.20.90.46 1v2yA00 Mus musculusU11/U12 small nuclear ribonucleoprotein 25 kDa protein Molscript image for 1v2yA00 1
3.10.20.90.47 1gjzA00 Molscript image for 1gjzA00 2

Close Structural Clusters 3.10.20.90 (< 5Å)

Summary of "distant" structural clusters found within this level of CATH.
Cluster ID Example Domain Domains in Cluster Structural Alignment (Core) Structural Alignment (Expanded)
00003.00010.00020.00090/SSG5/1 1wxmA01 4
00003.00010.00020.00090/SSG5/2 2zjdA00 2
00003.00010.00020.00090/SSG5/3 1e8yA01 2
00003.00010.00020.00090/SSG5/4 1wm3A00 8
00003.00010.00020.00090/SSG5/5 2r2oA00 5
00003.00010.00020.00090/SSG5/6 1k8rB00 2
00003.00010.00020.00090/SSG5/7 1lfdA00 2
00003.00010.00020.00090/SSG5/8 1m94A00 15


Distant Structural Clusters 3.10.20.90 (< 9Å)

Summary of "distant" structural clusters found within this level of CATH.
Cluster ID Example Domain Domains in Cluster Structural Alignment (Core) Structural Alignment (Expanded)
00003.00010.00020.00090/SSGA9/1 1v2yA00 2
00003.00010.00020.00090/SSGA9/2 3d32B00 8
00003.00010.00020.00090/SSGA9/3 1v86A00 2


Structural Comparisons for Non-redundant S35 Representatives of 3.10.20.90 ( entries)