CATH Classification

Domain Context

CATH Clusters

Superfamily 3.90.940.10
Functional Family DNA-directed RNA polymerase subunit omega

Enzyme Information

2.7.7.6
DNA-directed RNA polymerase.
based on mapping to UniProt P0A800
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.

UniProtKB Entries (2)

P0A7Z4
RPOA_ECOLI
Escherichia coli K-12
DNA-directed RNA polymerase subunit alpha
Q0P6L9
Q0P6L9_ECOLX
Escherichia coli
RNA polymerase sigma factor RpoD

PDB Structure

PDB 6N61
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural mechanism of transcription inhibition by lasso peptides microcin J25 and capistruin.
Braffman, N.R., Piscotta, F.J., Hauver, J., Campbell, E.A., Link, A.J., Darst, S.A.
Proc. Natl. Acad. Sci. U.S.A.