The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: RNA polymerase subunit, RPB6/omega

Prokaryotes contain a single RNA polymerase (RNAP) that is responsible for the transcription of all genes, while eukaryotes have three classes of RNAPs (I-III) with specific transcriptional roles. In eukaryotes, the RPB6 subunit (also known as RPABC2) is common to all three polymerases. RPB6 is involved in the initiation of transcription. Bacterial DNA-dependent RNAP contains a small subunit termed omega, where the complete RNAP composition is beta'-beta-alpha(I)-alpha(II)-omega. The bacterial omega subunit is homologous in sequence and structure to the eukaryotic RPB6 subunit; they also have similar functional roles, being able to promote RNA polymerase assembly, possibly through a latching mechanism PMID:11158566.


GO Diversity

Unique GO annotations
43 Unique GO terms

EC Diversity

Unique EC annotations
1 Unique EC terms

Species Diversity

Unique species annotations
15025 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 296
Domain clusters (>95% seq id): 11
Domain clusters (>35% seq id): 6
Unique PDBs: 239
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 13
Unique EC: 1
Unique GO: 43
Unique Species: 15025