CATH Classification

Domain Context

CATH Clusters

Superfamily Dihydropteroate synthase-like
Functional Family Dihydropteroate synthase

Enzyme Information

2.5.1.15
Dihydropteroate synthase.
based on mapping to UniProt O05701
6-hydroxymethyl-7,8-dihydropterin diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate.
-!- The enzyme participates in the biosynthetic pathways for folate (in bacteria, plants and fungi) and methanopterin (in archaea). -!- The enzyme exists in varying types of multifunctional proteins in different organisms. -!- The enzyme from the plant Arabidopsis thaliana also harbors the activity of EC 2.7.6.3, while the enzyme from yeast Saccharomyces cerevisiae is trifunctional with the two above mentioned activities as well as EC 4.1.2.25.

UniProtKB Entries (1)

O05701
DHPS_STAAU
Staphylococcus aureus
Dihydropteroate synthase

PDB Structure

PDB 6CLV
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The Structural and Functional Basis for Recurring Sulfa Drug Resistance Mutations inStaphylococcus aureusDihydropteroate Synthase.
Griffith, E.C., Wallace, M.J., Wu, Y., Kumar, G., Gajewski, S., Jackson, P., Phelps, G.A., Zheng, Z., Rock, C.O., Lee, R.E., White, S.W.
Front Microbiol