CATH Classification

Domain Context

CATH Clusters

Superfamily Glycosidases
Functional Family Alpha,alpha-phosphotrehalase

Enzyme Information

3.2.1.10
Oligo-1,6-glucosidase.
based on mapping to UniProt O06994
Hydrolysis of (1->6)-alpha-D-glucosidic linkages in some oligosaccharides produced from starch and glycogen by alpha-amylase, and in isomaltose.
-!- This enzyme, like EC 3.2.1.33, can release an alpha-1->6-linked glucose, whereas the shortest chain that can be released by EC 3.2.1.41, EC 3.2.1.142 and EC 3.2.1.68 is maltose. -!- It also hydrolyzes isomaltulose (palatinose), isomaltotriose and panose, but has no action on glycogen or phosphorylase limit dextrin. -!- The enzyme from intestinal mucosa is a single polypeptide chain that also catalyzes the reaction of EC 3.2.1.48. -!- Differs from EC 3.2.1.33 in its preference for short-chain substrates and in its not requiring the 6-glucosylated residue to be at a branch point, i.e. linked at both C-1 and C-4.

UniProtKB Entries (1)

O06994
O16G1_BACSU
Bacillus subtilis subsp. subtilis str. 168
Oligo-1,6-glucosidase 1

PDB Structure

PDB 5WCZ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Dynamical origins of heat capacity changes in enzyme-catalysed reactions.
van der Kamp, M.W., Prentice, E.J., Kraakman, K.L., Connolly, M., Mulholland, A.J., Arcus, V.L.
Nat Commun