CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.20 | Alpha-Beta Barrel | |
3.20.20 | TIM Barrel | |
3.20.20.80 | Glycosidases |
Domain Context
CATH Clusters
Superfamily | Glycosidases |
Functional Family | O-GlcNAcase BT_4395 |
Enzyme Information
3.2.1.169 |
Protein O-GlcNAcase.
based on mapping to UniProt O60502
(1) [Protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-serine + H(2)O = [protein]-L-serine + N-acetyl-D-glucosamine. (2) [Protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonine + H(2)O = [protein]-L-threonine + N-acetyl-D-glucosamine.
-!- Within higher eukaryotes post-translational modification of protein serines/threonines with N-acetylglucosamine (O-GlcNAc) is dynamic, inducible and abundant, regulating many cellular processes by interfering with protein phosphorylation. -!- EC 2.4.1.155 transfers GlcNAc onto substrate proteins and EC 3.2.1.169 cleaves GlcNAc from the modified proteins.
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UniProtKB Entries (1)
O60502 |
OGA_HUMAN
Homo sapiens
Protein O-GlcNAcase
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PDB Structure
PDB | 5UN9 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Structures of human O-GlcNAcase and its complexes reveal a new substrate recognition mode.
Nat. Struct. Mol. Biol.
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