CATH Classification

Domain Context

CATH Clusters

Superfamily Glycosidases
Functional Family O-GlcNAcase BT_4395

Enzyme Information

3.2.1.169
Protein O-GlcNAcase.
based on mapping to UniProt O60502
(1) [Protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-serine + H(2)O = [protein]-L-serine + N-acetyl-D-glucosamine. (2) [Protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonine + H(2)O = [protein]-L-threonine + N-acetyl-D-glucosamine.
-!- Within higher eukaryotes post-translational modification of protein serines/threonines with N-acetylglucosamine (O-GlcNAc) is dynamic, inducible and abundant, regulating many cellular processes by interfering with protein phosphorylation. -!- EC 2.4.1.155 transfers GlcNAc onto substrate proteins and EC 3.2.1.169 cleaves GlcNAc from the modified proteins.

UniProtKB Entries (1)

O60502
OGA_HUMAN
Homo sapiens
Protein O-GlcNAcase

PDB Structure

PDB 5UN9
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structures of human O-GlcNAcase and its complexes reveal a new substrate recognition mode.
Li, B., Li, H., Lu, L., Jiang, J.
Nat. Struct. Mol. Biol.