CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
Functional Family Putative ubiquitin carboxyl-terminal hydrolase 7

Enzyme Information

3.4.19.12
Ubiquitinyl hydrolase 1.
based on mapping to UniProt Q93009
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
-!- Links to polypeptides smaller than 60 residues are hydrolyzed more readily than those to larger polypeptides. -!- Isoforms exist with quantitatively different specificities among the best known being UCH-L1 and UCH-L3, major proteins of the brain of mammals. -!- Inhibited by ubiquitin aldehyde (in which Gly76 is replaced by aminoacetaldehyde). -!- Belongs to peptidase family C12.

UniProtKB Entries (1)

Q93009
UBP7_HUMAN
Homo sapiens
Ubiquitin carboxyl-terminal hydrolase 7

PDB Structure

PDB 5J7T
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Molecular Understanding of USP7 Substrate Recognition and C-Terminal Activation.
Rouge, L., Bainbridge, T.W., Kwok, M., Tong, R., Di Lello, P., Wertz, I.E., Maurer, T., Ernst, J.A., Murray, J.
Structure