CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.10 | Roll | |
3.10.20 | Ubiquitin-like (UB roll) | |
3.10.20.90 | Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1 |
Domain Context
CATH Clusters
Superfamily | Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1 |
Functional Family |
Enzyme Information
2.7.1.153 |
Phosphatidylinositol-4,5-bisphosphate 3-kinase.
based on mapping to UniProt O35904
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate.
-!- This enzyme also catalyzes the phosphorylation of PtdIns4P to PtdIns(3,4)P(2), and of PtdIns to PtdIns3P.
|
UniProtKB Entries (1)
O35904 |
PK3CD_MOUSE
Mus musculus
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
|
PDB Structure
PDB | 5IS5 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Discovery and Pharmacological Characterization of Novel Quinazoline-Based PI3K Delta-Selective Inhibitors.
Acs Med.Chem.Lett.
|