CATH Classification

Domain Context

CATH Clusters

Superfamily Glycosidases
Functional Family Chitotriosidase-1

Enzyme Information

3.2.1.14
Chitinase.
based on mapping to UniProt Q13231
Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta- linkages in chitin and chitodextrins.
-!- The enzyme binds to chitin and randomly cleaves glycosidic linkages in chitin and chitodextrins in a non-processive mode, generating chitooligosaccharides and free ends on which exo-chitinases and exo- chitodextrinases can act. -!- Activity is greatly stimulated in the presence of EC 1.14.99.53, which attacks the crystalline structure of chitin and makes the polymer more accesible to the chitinase. -!- Cf. EC 3.2.1.202.

UniProtKB Entries (1)

Q13231
CHIT1_HUMAN
Homo sapiens
Chitotriosidase-1

PDB Structure

PDB 5HBF
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
X-Ray Crystal Structure of the Full Length Human Chitotriosidase (CHIT1) Reveals Features of Its Chitin Binding Domain.
Fadel, F., Zhao, Y., Cousido-Siah, A., Ruiz, F.X., Mitschler, A., Podjarny, A.
Plos One