CATH Classification

Domain Context

CATH Clusters

Superfamily Glycosidases
Functional Family Beta-hexosaminidase A

Enzyme Information

3.2.1.52
Beta-N-acetylhexosaminidase.
based on mapping to UniProt P07686
Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.
-!- Acts on N-acetylglucosides and N-acetylgalactosides. -!- Formerly EC 3.2.1.29 and EC 3.2.1.30.

UniProtKB Entries (1)

P07686
HEXB_HUMAN
Homo sapiens
Beta-hexosaminidase subunit beta

PDB Structure

PDB 5BRO
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Protease-resistant modified human beta-hexosaminidase B ameliorates symptoms in GM2 gangliosidosis model.
Kitakaze, K., Mizutani, Y., Sugiyama, E., Tasaki, C., Tsuji, D., Maita, N., Hirokawa, T., Asanuma, D., Kamiya, M., Sato, K., Setou, M., Urano, Y., Togawa, T., Otaka, A., Sakuraba, H., Itoh, K.
J.Clin.Invest.