CATH Classification

Domain Context

CATH Clusters

Superfamily 2.40.50.40
Functional Family Chromodomain-helicase-DNA-binding protein 2 isoform 1

Enzyme Information

3.6.4.12
DNA helicase.
based on mapping to UniProt O14646
ATP + H(2)O = ADP + phosphate.
-!- DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA. -!- Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15). -!- Some helicases unwind DNA as well as RNA (4,9). -!- May be identical with EC 3.6.4.13 (RNA helicase).

UniProtKB Entries (1)

O60341
KDM1A_HUMAN
Homo sapiens
Lysine-specific histone demethylase 1A

PDB Structure

PDB 5AFW
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Assembly of Methylated Kdm1A and Chd1 Drives Androgen Receptor-Dependent Transcription and Translocation.
Metzger, E., Willmann, D., Mcmillan, J., Forne, I., Metzger, P., Gerhardt, S., Petroll, K., Von Maessenhausen, A., Urban, S., Schott, A., Espejo, A., Eberlin, A., Wohlwend, D., Schule, K.M., Schleicher, M., Perner, S., Bedford, M.T., Jung, M., Dengjel, J., Flaig, R., Imhof, A., Einsle, O., Schule, R.
Nat.Struct.Mol.Biol.