CATH Classification

Domain Context

CATH Clusters

Superfamily Divalent-metal-dependent TIM barrel enzymes
Functional Family Xylose isomerase

Enzyme Information

5.3.1.5
Xylose isomerase.
based on mapping to UniProt Q8A9M2
D-xylopyranose = D-xylulose.
-!- The enzyme catalyzes the interconversion of aldose and ketose sugars with broad substrate specificity. -!- The enzyme binds the closed form of its sugar substrate (in the case of glucose, only the alpha anomer) and catalyzes ring opening to generate a form of open-chain conformation that is coordinated to one of the metal sites. -!- Isomerization proceeds via a hydride-shift mechanism.

UniProtKB Entries (1)

Q8A9M2
XYLA_BACTN
Bacteroides thetaiotaomicron VPI-5482
Xylose isomerase

PDB Structure

PDB 4XKM
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of a class 2 D-xylose isomerase from the human intestinal tract microbe Bacteroides thetaiotaomicron
Han, B.G., Bong, S.M., Cho, J.W., Kim, M.D., Kim, S.J., Lee, B.I.
Biodesign