CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.20 | Alpha-Beta Barrel |
|
3.20.20 | TIM Barrel |
|
3.20.20.70 | Aldolase class I |
Domain Context
CATH Clusters
| Superfamily | Aldolase class I |
| Functional Family | Proline 2-methylase for pyrrolysine biosynthesis |
Enzyme Information
| 5.4.99.58 |
Methylornithine synthase.
based on mapping to UniProt Q46E78
L-lysine = (3R)-3-methyl-D-ornithine.
-!- The enzyme is a member of the superfamily of S-adenosyl-L-methionine- dependent radical (radical AdoMet) enzymes. -!- Binds a [4Fe-4S] cluster that is coordinated by 3 cysteines and an exchangeable S-adenosyl-L-methionine molecule. -!- The reaction is part of the biosynthesis pathway of pyrrolysine, a naturally occurring amino acid found in some archaeal methyltransferases.
|
UniProtKB Entries (1)
| Q46E78 |
PYLB_METBF
Methanosarcina barkeri str. Fusaro
3-methylornithine synthase
|
PDB Structure
| PDB | 3T7V |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structure of methylornithine synthase (PylB): insights into the pyrrolysine biosynthesis.
Angew.Chem.Int.Ed.Engl.
|