CATH Classification

Domain Context

CATH Clusters

Superfamily Aldolase class I
Functional Family 4-hydroxy-2-oxoglutarate aldolase, mitochondrial isoform X1

Enzyme Information

4.1.3.16
4-hydroxy-2-oxoglutarate aldolase.
based on mapping to UniProt Q86XE5
4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate.
-!- The enzymes from rat liver and bovine liver act on both enantiomers of 4-hydroxy-2-oxoglutarate. -!- Formerly EC 4.1.2.1 and EC 4.1.2.31.

UniProtKB Entries (1)

Q86XE5
HOGA1_HUMAN
Homo sapiens
4-hydroxy-2-oxoglutarate aldolase, mitochondrial

PDB Structure

PDB 3S5O
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural and Biochemical Studies of Human 4-hydroxy-2-oxoglutarate Aldolase: Implications for Hydroxyproline Metabolism in Primary Hyperoxaluria.
Riedel, T.J., Johnson, L.C., Knight, J., Hantgan, R.R., Holmes, R.P., Lowther, W.T.
Plos One