CATH Classification

Domain Context

CATH Clusters

Superfamily Aldolase class I
Functional Family Hydroxymethylglutaryl-CoA lyase, mitochondrial

Enzyme Information

4.1.3.4
Hydroxymethylglutaryl-CoA lyase.
based on mapping to UniProt P35914
(S)-3-hydroxy-3-methylglutaryl-CoA = acetyl-CoA + acetoacetate.

UniProtKB Entries (1)

P35914
HMGCL_HUMAN
Homo sapiens
Hydroxymethylglutaryl-CoA lyase, mitochondrial

PDB Structure

PDB 3MP5
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Functional insights into human HMG-CoA lyase from structures of Acyl-CoA-containing ternary complexes.
Fu, Z., Runquist, J.A., Montgomery, C., Miziorko, H.M., Kim, J.J.
J.Biol.Chem.