CATH Classification

Domain Context

CATH Clusters

Superfamily Aldolase class I
Functional Family 2-isopropylmalate synthase

Enzyme Information

2.3.3.13
2-isopropylmalate synthase.
based on mapping to UniProt P9WQB3
Acetyl-CoA + 3-methyl-2-oxobutanoate + H(2)O = (2S)-2-isopropylmalate + CoA.
-!- Formerly EC 4.1.3.12.

UniProtKB Entries (1)

P9WQB3
LEU1_MYCTU
Mycobacterium tuberculosis H37Rv
2-isopropylmalate synthase

PDB Structure

PDB 3HQ1
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Probing the active site of M. tuberculosis LeuA
Koon, N., Squire, C.J., Baker, E.N.
To be Published