CATH Classification

Domain Context

CATH Clusters

Superfamily Enolase-like C-terminal domain
Functional Family L-Ala-D/L-Glu epimerase

Enzyme Information

5.1.1.20
L-Ala-D/L-Glu epimerase.
based on mapping to UniProt Q9WXM1
L-alanyl-D-glutamate = L-alanyl-L-glutamate.
-!- The enzyme, characterized from the bacteria Escherichia coli and Bacillus subtilis, is involved in the recycling of the murein peptide, of which L-Ala-D-Glu is a component. -!- In vitro the enzyme from E.coli epimerizes several L-Ala-L-X dipeptides with broader specificity than the enzyme from B.subtilis. -!- Formerly EC 5.1.1.n1.

UniProtKB Entries (1)

Q9WXM1
AEEP_THEMA
Thermotoga maritima MSB8
L-Ala-D/L-Glu epimerase

PDB Structure

PDB 3DFY
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery of a dipeptide epimerase enzymatic function guided by homology modeling and virtual screening.
Kalyanaraman, C., Imker, H.J., Fedorov, A.A., Fedorov, E.V., Glasner, M.E., Babbitt, P.C., Almo, S.C., Gerlt, J.A., Jacobson, M.P.
Structure