CATH Classification

Domain Context

CATH Clusters

Superfamily Aldolase class I
Functional Family Pyridoxal 5'-phosphate synthase subunit PdxS

Enzyme Information

4.3.3.6
Pyridoxal 5'-phosphate synthase (glutamine hydrolyzing).
based on mapping to UniProt Q58090
D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + 3 H(2)O + phosphate.
-!- The ammonia is provided by the glutaminase subunit and channeled to the active site of the lyase subunit by a 100 A tunnel. -!- The enzyme can also use ribulose 5-phosphate and dihydroxyacetone phosphate. -!- The enzyme complex is found in aerobic bacteria, archeae, fungi and plants.

UniProtKB Entries (1)

Q58090
PDXS_METJA
Methanocaldococcus jannaschii DSM 2661
Pyridoxal 5'-phosphate synthase subunit PdxS

PDB Structure

PDB 2YZR
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of pyridoxine biosynthesis protein from Methanocaldococcus jannaschii
Manzoku, M., Ebihara, A., Chen, L., Fu, Z.-Q., Chrzas, J., Wang, B.-C., Yokoyama, S., Kuramitsu, S.
to be published