CATH Classification

Domain Context

CATH Clusters

Superfamily Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
Functional Family Myotubularin related protein 6

Enzyme Information

3.1.3.64
Phosphatidylinositol-3-phosphatase.
based on mapping to UniProt Q9Y217
1-phosphatidyl-1D-myo-inositol 3-phosphate + H(2)O = 1-phosphatidyl- 1D-myo-inositol + phosphate.
-!- This enzyme still works when the 2,3-bis(acyloxy)propyl group is removed, i.e., it hydrolyzes Ins(1,3)P(2) to Ins-1-P. -!- Formerly EC 3.1.3.65.
3.1.3.95
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase.
based on mapping to UniProt Q9Y217
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H(2)O = 1-phosphatidyl- 1D-myo-inositol 5-phosphate + phosphate.
-!- The enzyme is found in both plants and animals. -!- It also has the activity of EC 3.1.3.64.

UniProtKB Entries (1)

Q9Y217
MTMR6_HUMAN
Homo sapiens
Myotubularin-related protein 6

PDB Structure

PDB 2YF0
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of Human Mtmr6
Moche, M., Tresaugues, L., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, I., Karlberg, T., Kotenyova, T., Kouznetsova, E., Nyman, T., Persson, C., Schuler, H., Schutz, P., Siponen, M.I., Thorsell, A.G., Vandenberg, S., Wahlberg, E., Weigelt, J., Welin, M., Nordlund, P.
To be Published