CATH Classification

Domain Context

CATH Clusters

Superfamily 3.10.20.30
Functional Family Succinate dehydrogenase iron-sulfur subunit

Enzyme Information

1.3.5.1
Succinate dehydrogenase (quinone).
based on mapping to UniProt P07014
Succinate + a quinone = fumarate + a quinol.
-!- The enzyme is found in the inner mitochondrial membrane in eukaryotes and the plasma membrane of many aerobic or facultative bacteria. -!- It catalyzes succinate oxidation in the citric acid cycle and transfers the electrons to quinones in the membrane, thus constituting a part of the aerobic respiratory chain (known as complex II). -!- In vivo the enzyme uses the quinone found in the organism - eukaryotic enzymes utilize ubiquinone, bacterial enzymes utilize ubiquinone or menaquinone, and archaebacterial enzymes from the Sulfolobus genus use caldariellaquinone. -!- Cf. EC 1.3.5.4.

UniProtKB Entries (1)

P69054
DHSC_ECOLI
Escherichia coli K-12
Succinate dehydrogenase cytochrome b556 subunit

PDB Structure

PDB 2WU2
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of the E. Coli Succinate:Quinone Oxidoreductase (Sqr) Sdhc His84met Mutant
Ruprecht, J., Yankovskaya, V., Maklashina, E., Iwata, S., Cecchini, G.
To be Published