CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family

Enzyme Information
Type I site-specific deoxyribonuclease.
based on mapping to UniProt P10486
Endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5'-phosphates, ATP is simultaneously hydrolyzed.
-!- Large group of enzymes that have an absolute requirement for ATP (or dATP) and S-adenosyl-L-methionine. -!- They recognize specific short DNA sequences and cleave at sites remote from the recognition sequence. -!- Multifunctional proteins which also catalyze the reactions of EC and EC, with similar site specificity. -!- Formerly EC and EC -!- See the REBASE database for a complete list of these enzymes:

UniProtKB Entries (1)

Escherichia coli
Type I restriction enzyme EcoR124II R protein

PDB Structure

PDB 2W00
External Links
Primary Citation
Structure of the Motor Subunit of Type I Restriction-Modification Complex Ecor124I.
Lapkouski, M., Panjikar, S., Janscak, P., Smatanova, I.K., Carey, J., Ettrich, R., Csefalvay, E.