Homologous Superfamily: 3.40.50.300

Representative domain: 1byiA00

P-loop containing nucleotide triphosphate hydrolases

Classification Lineage (3.40.50.300)

CATH Code	Level Description	Links
3	Alpha Beta
3.40	3-Layer(aba) Sandwich
3.40.50	Rossmann fold
3.40.50.300	P-loop containing nucleotide triphosphate hydrolases	Gene3D

Summary of Non-Redundant Representatives


-	-	-	-	230	356	473	898	2970

Non-Redundant Representatives (230)
Alignments (79)
Structural Neighbours ()
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S35 Family Entries in Homologous Superfamily 3.40.50.300 (230)

CATH code	Representative Domain	Representative Keywords	Number of Domains
3.40.50.300.1	1byiA00	Dethiobiotin synthase activityDethiobiotin synthase.Biotin biosynthetic processMetabolic pathwaysEscherichia coli K-12	13
3.40.50.300.2	2gxqA00	Heat resistant RNA dependent ATPaseThermus thermophilus	9
3.40.50.300.3	2oxcA00	ATP-dependent RNA helicase activityATP-dependent RNA helicase DDX20 [EC:3.6.1.-]In phosphorous-containing anhydrides.CytoskeletonProbable ATP-dependent RNA helicase DDX20	17
3.40.50.300.4	2j45A02	Thermus aquaticusSignal recognition particle proteinProtein binding	31
3.40.50.300.5	1m7gC00	Adenylyl-sulfate kinase.Adenylyl-sulfate kinasePenicillium chrysogenum	38
3.40.50.300.6	2c78A01	Thermus thermophilus HB8Elongation factor Tu-AElongation factor EF-Tu [EC:3.6.5.3]	38
3.40.50.300.7	1zd8A00	Pyrimidine metabolismNucleoside-triphosphate--adenylate kinase.GTP:AMP phosphotransferase mitochondrialNucleoside-triphosphate--adenylate kinase [EC:2.7.4.10]Homo sapiens	9
3.40.50.300.8	3gj0A00	DNA metabolic processGTP bindingMitosisChromatin bindingMitotic spindle organization	14
3.40.50.300.9	2qmoA00	Biotin metabolismDethiobiotin synthetaseHelicobacter pyloriDethiobiotin synthase.Dethiobiotin synthetase [EC:6.3.3.3]	1
3.40.50.300.10	1nn3A00	Thymidylate kinaseDTMP kinase.Cell cycleThymidylate kinase activityHomo sapiens	36
3.40.50.300.11	1gtvA00	Thymidylate kinasePyrimidine metabolismDTMP kinase.Mycobacterium tuberculosisMetabolic pathways	16
3.40.50.300.12	1vmaA02	Thermotoga maritimaProtein exportBacterial secretion systemCell division protein FtsYFused signal recognition particle receptor	5
3.40.50.300.13	2hxsA00	GTPase activityGTP bindingRas-related protein Rab-28Homo sapiensGDP binding	3
3.40.50.300.14	1vhtA00	Dephospho-CoA kinase activityDephospho-CoA kinase [EC:2.7.1.24]Coenzyme A biosynthetic processDephospho-CoA kinase.Pantothenate and CoA biosynthesis	16
3.40.50.300.15	3dl0A00	Bacillus subtilisAdenylate kinasePurine metabolismAdenylate kinase [EC:2.7.4.3]Adenylate kinase.	27
3.40.50.300.16	3be4A00	Cryptosporidium parvum Iowa IIPurine metabolismAdenylate kinaseAdenylate kinase [EC:2.7.4.3]Metabolic pathways	23
3.40.50.300.17	1r2qA00	GTP bindingRas-related protein Rab-5AGDP bindingEndocytosisGTPase activity	45
3.40.50.300.18	2ce2X00	SenescenceNeurotrophin signaling pathwayNon-small cell lung cancerT cell receptor signaling pathwayErbB signaling pathway	139
3.40.50.300.19	1cipA01	Rattus norvegicusGuanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptideGuanine nucleotide-binding protein G(i) subunit alpha-1Chagas diseaseChemokine signaling pathway	43
3.40.50.300.20	1ukvY00	GTP-binding protein YPT1Endoplasmic reticulum membraneRab family, otherER to Golgi vesicle-mediated transportProtein binding	10
3.40.50.300.21	2qt1A00	Ribosylnicotinamide kinase.Nicotinamide riboside kinase 1Homo sapiensNicotinamide riboside kinase.	22
3.40.50.300.22	1ckeA00	Cytidylate kinase [EC:2.7.4.14]Pyrimidine metabolismEscherichia coli K-12Cytidylate kinase.Metabolic pathways	16
3.40.50.300.23	1jnyA01	Sulfolobus solfataricusElongation factor 1-alphaElongation factor EF-1 alpha subunit [EC:3.6.5.3]	13
3.40.50.300.24	1mh1A00	Neurotrophin signaling pathwayCell adhesionRas-related C3 botulinum toxin substrate 1MAPK signaling pathwayCellular component movement	139
3.40.50.300.25	1n0wA00	Identical protein bindingDouble-strand break repair via homologous recombinationReciprocal meiotic recombinationProtein homooligomerizationDNA unwinding involved in replication	40
3.40.50.300.26	2cbzA00	ATP bindingMembrane fractionIntegral to plasma membraneResponse to drugATP-binding cassette, subfamily C (CFTR/MRP), member 1	1
3.40.50.300.27	2qm8A02	Methylobacterium extorquensGTPase/ATPase	9
3.40.50.300.28	2no7B00	Pyrimidine metabolismPurine metabolismDeoxycytidine kinase.Deoxycitidine kinase [EC:2.7.1.74]Deoxycytidine kinase activity	69
3.40.50.300.29	1uj2A00	Pyrimidine metabolismUridine kinase.Drug metabolism - other enzymesUridine kinase [EC:2.7.1.48]Homo sapiens	16
3.40.50.300.30	2iyvA00	Phenylalanine, tyrosine and tryptophan biosynthesisShikimate kinase [EC:2.7.1.71]Shikimate kinaseShikimate kinase.Mycobacterium tuberculosis	27
3.40.50.300.31	1sgwA00	Pyrococcus furiosusABC-2 type transport system ATP-binding proteinPutative ABC transporter (ATP-binding protein)	1
3.40.50.300.32	1x3sA00	IntracellularRas-related protein Rab-18Homo sapiens	9
3.40.50.300.33	1wmsA00	LysosomeGTP bindingRas-related protein Rab-9AProtein bindingGDP binding	22
3.40.50.300.34	2wwfA00	Pyrimidine metabolismPlasmodium falciparum 3D7Thymidylate kinase, putativeMetabolic pathwaysDTMP kinase [EC:2.7.4.9]	12
3.40.50.300.35	2pcjA00	Acting on acid anhydrides; catalyzing transmembrane movement of substances.Lipoprotein-releasing system ATP-binding protein LolDAquifex aeolicus	10
3.40.50.300.36	1xmvA01	Homologous recombinationProtein recARecombination protein RecAEscherichia coli K-12	17
3.40.50.300.37	2c95A00	Adenylate kinase isoenzyme 1Purine metabolismNucleusProtein bindingMetabolic pathways	13
3.40.50.300.38	1qf9A00	Pyrimidine metabolismPyrimidine base salvageCDP biosynthetic processPhosphotransferase activity, phosphate group as acceptorCytidylate kinase.	10
3.40.50.300.39	1z0jA00	Mus musculusGTPase activityGTP bindingRas-related protein Rab-22AProtein binding	3
3.40.50.300.40	1oxxK01	ABC transporter, ATP binding protein (Glucose)Glucose/arabinose transport system ATP-binding proteinSulfolobus solfataricusABC transporters	34
3.40.50.300.41	1q0uB00	Geobacillus stearothermophilusRNA binding protein	2
3.40.50.300.42	4tmkA00	Pyrimidine metabolismDTTP biosynthetic processEscherichia coli K-12Metabolic pathwaysNucleobase, nucleoside and nucleotide interconversion	2
3.40.50.300.43	2xb4A00	Adenylate kinaseDesulfovibrio gigasAdenylate kinase.	1
3.40.50.300.44	3czpB01	Pseudomonas aeruginosaPutative uncharacterized protein	2
3.40.50.300.45	1nrjB00	SRP-dependent cotranslational protein targeting to membraneGTP bindingSignal recognition particle receptor subunit betaProtein bindingIntegral to endoplasmic reticulum membrane	1
3.40.50.300.46	2f6rA00	Bifunctional coenzyme A synthaseCoenzyme A biosynthetic processDephospho-CoA kinase.Pantetheine-phosphate adenylyltransferase [EC:2.7.7.3]Pantetheine-phosphate adenylyltransferase activity	1
3.40.50.300.47	1kk1A01	Pyrococcus abyssiTranslation initiation factor eIF-2 gamma subunitTranslation initiation factor 2 subunit gamma	18
3.40.50.300.48	3b6eA00	Zinc ion bindingInterferon-induced helicase C domain-containing protein 1 [EC:3.6.1.-]RIG-I-like receptor signaling pathwayIn phosphorous-containing anhydrides.Interferon-induced helicase C domain-containing protein 1	1
3.40.50.300.49	3c8uA00	Amino sugar and nucleotide sugar metabolismFructokinaseFructose and mannose metabolismRuegeria sp. TM1040Fructokinase.	1
3.40.50.300.50	1c4oA03	Thermus thermophilus HB8UvrABC system protein BNucleotide excision repairExcinuclease ABC subunit B	10
3.40.50.300.51	1lv7A01	Zinc ion bindingATPase activityIntegral to membraneMetalloendopeptidases.Proteolysis	31
3.40.50.300.52	2vhjA01	NTPase P4Pseudomonas phage phi12	60
3.40.50.300.53	1bifA01	Identical protein bindingRattus norvegicus6-phosphofructo-2-kinase activityFructose-2,6-bisphosphate 2-phosphatase.6-phosphofructo-2-kinase [EC:2.7.1.105]	10
3.40.50.300.54	1vecA00	Probable ATP-dependent RNA helicase DDX6ATP-dependent RNA helicase DDX6/DHH1 [EC:3.6.1.-]In phosphorous-containing anhydrides.RNA degradationHomo sapiens	3
3.40.50.300.55	2p65A00	ClpB protein, putativePlasmodium falciparum 3D7	7
3.40.50.300.56	1n0uA01	Positive regulation of translational elongationElongation factor 2Elongation factor EF-2 [EC:3.6.5.3]Protein bindingRibonucleoprotein binding	16
3.40.50.300.57	1mr3F00	Golgi-associated vesicleIdentical protein bindingGTPase activityIntra-Golgi vesicle-mediated transportER to Golgi vesicle-mediated transport	69
3.40.50.300.58	2rhmC00	Chloroflexus aurantiacus J-10-flPutative uncharacterized protein	4
3.40.50.300.59	3bs4A00	Pyrococcus horikoshiiPutative uncharacterized protein PH0321	1
3.40.50.300.60	1nijA01	Uncharacterized GTP-binding protein yjiAEscherichia coli K-12	1
3.40.50.300.61	1g7sA01	Methanothermobacter thermautotrophicus str. Delta HTranslation initiation factor IF-2 unclassified subunitProbable translation initiation factor IF-2	3
3.40.50.300.62	2fnaA01	Sulfolobus solfataricusPutative uncharacterized protein	3
3.40.50.300.63	1f6bB00	Cricetulus griseusGTP-binding protein SAR1b	11
3.40.50.300.64	1byuB00	Canis lupus familiarisGTP-binding nuclear protein Ran	35
3.40.50.300.65	1ewqB05	Thermus aquaticusDNA mismatch repair protein mutS	28
3.40.50.300.66	1tueD00	In phosphorous-containing anhydrides.Human papillomavirus type 18Replication protein E1	30
3.40.50.300.67	1sulB00	Bacillus subtilisProbable GTP-binding protein engBGTP-binding protein	7
3.40.50.300.68	1b0uA00	Histidine transport ATP-binding protein hisPSalmonella enterica subsp. enterica serovar TyphimuriumHistidine transport system ATP-binding protein [EC:3.6.3.21]ABC transporters	17
3.40.50.300.69	2is6A03	DNA helicase II / ATP-dependent DNA helicase PcrA [EC:3.6.1.-]Nucleotide excision repairIn phosphorous-containing anhydrides.Protein bindingMismatch repair	13
3.40.50.300.70	1dg3A02	GTP bindingInterferon-induced guanylate-binding protein 1Homo sapiens	9
3.40.50.300.71	2qu8A00		1
3.40.50.300.72	2r2aA00	Neisseria meningitidis serogroup BPutative uncharacterized protein	2
3.40.50.300.73	3cx8A01	Rho protein signal transductionGTPase activityIn utero embryonic developmentPlatelet activationRegulation of cell shape	24
3.40.50.300.74	1g8pA01	Porphyrin and chlorophyll metabolismMagnesium chelatase subunit I [EC:6.6.1.1]Rhodobacter capsulatusMagnesium-chelatase 38 kDa subunitMetabolic pathways	1
3.40.50.300.75	3ievA01	GTP-binding protein era homologGTP-binding protein EraAquifex aeolicus	6
3.40.50.300.76	1g6hA00	Methanocaldococcus jannaschiiProbable branched-chain amino acid transport ATP-binding protein livGBranched-chain amino acid transport system ATP-binding proteinABC transporters	5
3.40.50.300.77	1rifA02	ATP-dependent DNA helicase uvsWIn phosphorous-containing anhydrides.Enterobacteria phage T4	2
3.40.50.300.78	1bofA01	Rattus norvegicusGuanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptideGuanine nucleotide-binding protein G(i) subunit alpha-1Chemokine signaling pathwayChagas disease	21
3.40.50.300.79	2erxA00	DIRAS family, GTP-binding Ras-like 2Homo sapiensGTP-binding protein Di-Ras2	6
3.40.50.300.80	1ji0A00	Thermotoga maritimaBranched chain amino acid ABC transporter, ATP-binding proteinBranched-chain amino acid transport system ATP-binding proteinABC transporters	1
3.40.50.300.81	2obnA02	Anabaena variabilis ATCC 29413Putative uncharacterized protein	4
3.40.50.300.82	1d2nA01	Vesicle-fusing ATPaseCricetulus griseusProtein bindingVesicle-fusing ATPase.	2
3.40.50.300.83	2is6A01	DNA helicase II / ATP-dependent DNA helicase PcrA [EC:3.6.1.-]Nucleotide excision repairIn phosphorous-containing anhydrides.Protein bindingDNA helicase II	10
3.40.50.300.84	1t0jB00	Calcium channel regulator activityRattus norvegicusVoltage-dependent L-type calcium channel subunit beta-2Voltage-gated calcium channel complexCalcium ion transport	4
3.40.50.300.85	1y63A00	Leishmania majorPutative uncharacterized protein	2
3.40.50.300.86	2ixeD01	TAP complexTAP1 bindingRattus norvegicusMicrosomeMHC class I protein binding	8
3.40.50.300.87	2bbsB00	Vibrio cholerae infectionATP-binding cassette, subfamily C (CFTR/MRP), member 7Cystic fibrosis transmembrane conductance regulatorChannel-conductance-controlling ATPase.Early endosome	39
3.40.50.300.88	2zptX00	Mus musculusTyrosine-ester sulfotransferase.Sulfate assimilationAryl sulfotransferase activityTyrosine-ester sulfotransferase	40
3.40.50.300.89	2vp4D00	Deoxynucleoside kinase activityNucleoside diphosphate phosphorylationDeoxynucleoside kinaseDrosophila melanogaster[EC:2.7.1.145]	64
3.40.50.300.90	1rz3A00	Pyrimidine metabolismGeobacillus stearothermophilusUridine kinase [EC:2.7.1.48]Rbstp0775 proteinMetabolic pathways	1
3.40.50.300.91	1viaA00	Phenylalanine, tyrosine and tryptophan biosynthesisCampylobacter jejuniShikimate kinase [EC:2.7.1.71]Shikimate kinaseShikimate kinase.	6
3.40.50.300.92	2dbyA01	Thermus thermophilus HB8GTP-binding protein	7
3.40.50.300.93	1c4oA01	Thermus thermophilus HB8UvrABC system protein BNucleotide excision repairExcinuclease ABC subunit B	4
3.40.50.300.94	2r8rA00	Sensor proteinPseudomonas syringae pv. tomatoTwo-component systemTwo-component system, OmpR family, sensor histidine kinase KdpD [EC:2.7.13.3]Histidine kinase.	2
3.40.50.300.95	1g3qA00	Pyrococcus furiosusCell division inhibitor minD homologSeptum site-determining protein MinD	4
3.40.50.300.96	1g64B00	Porphyrin and chlorophyll metabolismSalmonella enterica subsp. enterica serovar TyphimuriumCob(I)alamin adenosyltransferase [EC:2.5.1.17]Cob(I)yrinic acid a,c-diamide adenosyltransferaseMetabolic pathways	4
3.40.50.300.97	1e6cA00	Erwinia chrysanthemiShikimate kinase 2Shikimate kinase.	6
3.40.50.300.98	1r6bX04	ATP-dependent Clp protease ATP-binding subunit clpAATP-dependent Clp protease ATP-binding subunit ClpAProtein bindingEscherichia coli K-12	5
3.40.50.300.99	3czpA02	Pseudomonas aeruginosaPutative uncharacterized protein	2
3.40.50.300.100	3dmnA00	DNA helicase II / ATP-dependent DNA helicase PcrA [EC:3.6.1.-]Nucleotide excision repairLactobacillus plantarumMismatch repairDNA helicase (Putative)	1
3.40.50.300.101	3cbqA00	Rad and Gem related GTP binding protein 2GTP-binding protein REM 2Homo sapiens	14
3.40.50.300.102	2pl3A00	In phosphorous-containing anhydrides.Homo sapiensProbable ATP-dependent RNA helicase DDX10RNA helicase activity	1
3.40.50.300.103	3defA00	Identical protein bindingTranslocase of chloroplast 33, chloroplasticGTPase activityArabidopsis thalianaGTP binding	15
3.40.50.300.104	1m7bA00	Actin cytoskeleton organizationRho-related GTP-binding protein RhoEGTPase activityGTP bindingCell adhesion	9
3.40.50.300.105	2bjwA01	TranscriptionTranscription activator activityTranscription repressor activityPsp operon transcriptional activatorEscherichia coli K-12	31
3.40.50.300.106	1htwA00	UPF0079 ATP-binding protein HI_0065Haemophilus influenzae	6
3.40.50.300.107	1vplA00	Thermotoga maritimaABC-2 type transport system ATP-binding proteinABC transporter, ATP-binding protein	1
3.40.50.300.108	3c5cB00	Ras-like protein family member 12Homo sapiensRas-like, family 12	5
3.40.50.300.109	3bosB01	DnaA-homolog proteinShewanella amazonensis SB2BRegulatory inactivation of DnaA Hda protein	2
3.40.50.300.110	3cwqA00	ParA family chromosome partitioning proteinSynechocystis sp. PCC 6803	2
3.40.50.300.111	1f2uA00	Exonuclease SbcCPyrococcus furiosusDNA double-strand break repair rad50 ATPase	5
3.40.50.300.112	1in4A01	Holliday junction DNA helicase RuvBThermotoga maritimaHomologous recombinationIn phosphorous-containing anhydrides.Holliday junction ATP-dependent DNA helicase ruvB	10
3.40.50.300.113	1g41A01	ATP-dependent hsl protease ATP-binding subunit hslUHaemophilus influenzaeATP-dependent HslUV protease ATP-binding subunit HslU	58
3.40.50.300.114	1fnnA02	Pyrobaculum aerophilumCell division control protein 6 (Cdc6), putativeArchaeal cell division control protein 6	2
3.40.50.300.115	1fukA00	ATP-dependent RNA helicase activityEukaryotic translation initiation factor 4F complexTranslational initiationProtein bindingATP-dependent RNA helicase eIF4A	9
3.40.50.300.116	3ea0A00	Pilus assembly protein CpaEChlorobaculum tepidumATPase, ParA family	2
3.40.50.300.117	1t9hA02	Ribosome biogenesis GTPase [EC:3.6.1.-]Putative ribosome biogenesis GTPase RsgABacillus subtilisIn phosphorous-containing anhydrides.	5
3.40.50.300.118	1knqA00	Thermoresistant gluconokinasePentose phosphate pathwayGluconokinase activityGluconokinase.Gluconokinase [EC:2.7.1.12]	12
3.40.50.300.119	1pjrA01	Geobacillus stearothermophilusATP-dependent DNA helicase pcrAIn phosphorous-containing anhydrides.	6
3.40.50.300.120	1z2aA00	Mus musculusRegulation of smoothened signaling pathwaySpinal cord dorsal/ventral patterningNegative regulation of proteolysisRas-related protein Rab-23	2
3.40.50.300.121	1nlfA00	Regulatory protein repAEscherichia coli	17
3.40.50.300.122	1udxA02	Thermus thermophilus HB8GTPase obgGTP-binding protein	3
3.40.50.300.123	1xtqA00	GTP-binding protein RhebGTPase activityInsulin signaling pathwayGTP bindingRas homolog enriched in brain	4
3.40.50.300.124	1c9kB00	Adenosylcobinamide kinase / adenosylcobinamide-phosphate guanylyltransferase [EC:2.7.1.156 2.7.7.62]Adenosylcobinamide-phosphate guanylyltransferase.Porphyrin and chlorophyll metabolismSalmonella enterica subsp. enterica serovar TyphimuriumBifunctional adenosylcobalamin biosynthesis protein cobU	6
3.40.50.300.125	1xtiA02	ATP-dependent RNA helicase activityIdentical protein bindingU6 snRNA bindingSpliceosomeSpliceosomal complex	4
3.40.50.300.126	2h57B00	ADP-ribosylation factor-like 6ADP-ribosylation factor-like protein 6Homo sapiens	3
3.40.50.300.127	2jgnB00	CytoplasmATP-dependent RNA helicase activityRIG-I-like receptor signaling pathwayATP-dependent RNA helicase [EC:3.6.1.-]ATP-dependent RNA helicase DDX3X	5
3.40.50.300.128	1ihuA01	Arsenical pump-driving ATPaseEscherichia coliArsenite-transporting ATPase.	6
3.40.50.300.129	2reoA01	Alcohol sulfotransferase activityAlcohol sulfotransferase.[EC:2.8.2.-]Sulfotransferase 1C3Homo sapiens	3
3.40.50.300.130	1s2mA02	Cytoplasmic mRNA processing body assemblyIdentical protein bindingCytoplasmic mRNA processing bodyStress granule assemblyRNA degradation	5
3.40.50.300.131	1nktA03	Protein exportBacterial secretion systemProtein translocase subunit secA 1Preprotein translocase subunit SecAMycobacterium tuberculosis	1
3.40.50.300.132	1wrbA00	DjVLGBDugesia japonica	4
3.40.50.300.133	1cr2A00	Enterobacteria phage T7DNA primase/helicaseNucleotidyltransferases.	23
3.40.50.300.134	1t8tA00	Glycosaminoglycan biosynthesis - heparan sulfate[Heparan sulfate]-glucosamine 3-sulfotransferase 3.Heparan sulfate glucosamine 3-O-sulfotransferase 3A1[heparan sulfate]-glucosamine 3-sulfotransferase 3 [EC:2.8.2.30]Integral to membrane	12
3.40.50.300.135	2pt7A02	Helicobacter pyloriCag alphaEpithelial cell signaling in Helicobacter pylori infectionBacterial secretion systemType IV secretion system protein VirB11	18
3.40.50.300.136	1njgA01	Pyrimidine metabolismDNA-dependent DNA replicationDNA replicationPurine metabolismATPase activity	20
3.40.50.300.137	2hjvA00	Bacillus subtilisATP-dependent RNA helicase dbpAIn phosphorous-containing anhydrides.	4
3.40.50.300.138	1zd1B00	Sulfotransferase 4A1Sulfotransferase 4A1 [EC:2.8.2.-]Homo sapiensSulfotransferases.	2
3.40.50.300.139	2r44A02	Cytophaga hutchinsonii ATCC 33406MoxR-like ATPase [EC:3.6.3.-]Putative uncharacterized protein	1
3.40.50.300.140	1khtB00	Adenylate kinaseMethanococcus voltaeAdenylate kinase.	16
3.40.50.300.141	1mkyA01	Thermotoga maritimaGTP-binding protein engAGTP-binding protein	1
3.40.50.300.142	1kgdA01	Non-specific serine/threonine protein kinase.Actin cytoskeletonGuanylate kinase activityPeripheral plasma membrane protein CASKCell adhesion	1
3.40.50.300.143	3fdiB00	Eubacterium ventriosum ATCC 27560Putative uncharacterized protein	2
3.40.50.300.144	3crmA01	Pseudomonas aeruginosaTRNA dimethylallyltransferase [EC:2.5.1.75]TRNA dimethylallyltransferase.TRNA dimethylallyltransferaseMetabolic pathways	4
3.40.50.300.145	3b85A00	Phosphate starvation-inducible protein PhoH and related proteinsPhosphate starvation-inducible protein PhoH, predicted ATPaseCorynebacterium glutamicum	2
3.40.50.300.146	3kb2A00	Bacillus subtilisSPBc2 prophage-derived uncharacterized protein yorR	4
3.40.50.300.147	1svmA03	Simian virus 40In phosphorous-containing anhydrides.Large T antigen	25
3.40.50.300.148	3fmoB00	CytoplasmNuclear poreIn phosphorous-containing anhydrides.ATP-dependent RNA helicase DDX19BRNA binding	5
3.40.50.300.149	1cp2A00	Nitrogenase iron protein 1Nitrogenase.Clostridium pasteurianum	70
3.40.50.300.150	1pujA01	Bacillus subtilisRibosome biogenesis GTPase A	1
3.40.50.300.151	2w58B01	Geobacillus kaustophilusPrimosomal protein DnaIPrimosome component (Helicase loader)	3
3.40.50.300.152	1mkyA02	Thermotoga maritimaGTP-binding proteinGTP-binding protein engA	1
3.40.50.300.153	1a5tA01	Pyrimidine metabolismDNA polymerase III subunit delta' [EC:2.7.7.7]DNA replicationPurine metabolismProtein binding	13
3.40.50.300.154	1gvnD00	Zeta-toxinStreptococcus pyogenes	2
3.40.50.300.155	1um8A01	Helicobacter pyloriATP-dependent Clp protease ATP-binding subunit clpXATP-dependent Clp protease ATP-binding subunit ClpX	1
3.40.50.300.156	1ly1A00	Polynucleotide kinasePolynucleotide 5'-hydroxyl-kinase.Enterobacteria phage T4	17
3.40.50.300.157	2ck3D02	ATP catabolic processParkinson's diseaseOxidative phosphorylationAlzheimer's diseaseMetabolic pathways	110
3.40.50.300.158	2chgA01	Archaeoglobus fulgidusReplication factor C small subunitReplication factor C small subunit	22
3.40.50.300.159	1ko7A02	Protein-serine/threonine kinases.HPr kinase/phosphorylaseStaphylococcus xylosusPhosphotransferases with a phosphate group as acceptor.	21
3.40.50.300.160	2g0tA02	Thermotoga maritimaPutative uncharacterized protein	2
3.40.50.300.161	1vytB02	Cardiac muscle contractionRattus norvegicusVoltage-gated calcium channel complexDilated cardiomyopathyCalcium channel, voltage-dependent, beta 3 subunit	6
3.40.50.300.162	1xzpA03	TRNA modification GTPaseThermotoga maritimaActing on GTP; involved in cellular and subcellular movement.TRNA modification GTPase mnmE	3
3.40.50.300.163	2nq2D00	Uncharacterized ABC transporter ATP-binding protein HI_1470Iron complex transport system ATP-binding protein [EC:3.6.3.34]Haemophilus influenzaeABC transporters	2
3.40.50.300.164	1zunB01	Selenoamino acid metabolismSulfur metabolismPurine metabolismAdenylylsulfate kinase [EC:2.7.1.25]Metabolic pathways	1
3.40.50.300.165	1qhxA00	Phosphotransferases with an alcohol group as acceptor.Streptomyces violaceusChloramphenicol 3-O phosphotransferase	6
3.40.50.300.166	1xwiA01	LysosomeATP catabolic processVacuolar protein sorting-associated protein 4BProtein C-terminus bindingNucleus	6
3.40.50.300.167	2bdtA00	Bacillus haloduransBH3686 protein	1
3.40.50.300.168	1texA00	Mycobacterium smegmatisSulfotransferase	4
3.40.50.300.169	1knxE02	Protein-serine/threonine kinases.HPr kinase/phosphorylaseMycoplasma pneumoniaePhosphotransferases with a phosphate group as acceptor.HPr kinase/phosphorylase [EC:2.7.11.- 2.7.4.-]	6
3.40.50.300.170	1q44A00	Flavonol sulfotransferase-likeBrassinosteroid metabolic processDefense responseBrassinosteroid sulfotransferase activityArabidopsis thaliana	2
3.40.50.300.171	2qi9C00	Vitamin B12-transporting ATPase.Vitamin B12 transport system ATP-binding protein [EC:3.6.3.33]Vitamin B12 import ATP-binding protein btuDPeripheral to membrane of membrane fractionEscherichia coli K-12	4
3.40.50.300.172	1np6B01	Molybdopterin-guanine dinucleotide biosynthesis protein BMolybdopterin-guanine dinucleotide biosynthesis protein BProtein bindingEscherichia coli K-12	4
3.40.50.300.173	2ck3A02	Oxidative phosphorylationParkinson's diseaseAlzheimer's diseaseMetabolic pathwaysF-type H+-transporting ATPase subunit alpha [EC:3.6.3.14]	111
3.40.50.300.174	1s96A01	Purine metabolismGuanylate kinase [EC:2.7.4.8]Guanylate kinaseGuanylate kinase.Metabolic pathways	10
3.40.50.300.175	2qorA01	Purine metabolismGuanylate kinase, putativePlasmodium vivaxGuanylate kinase [EC:2.7.4.8]Metabolic pathways	12
3.40.50.300.176	1j99A00	Bile-salt sulfotransferase [EC:2.8.2.14]Bile salt sulfotransferaseBile-salt sulfotransferase.Homo sapiens	14
3.40.50.300.177	1uf9A00	Thermus thermophilus HB8Dephospho-CoA kinase [EC:2.7.1.24]Dephospho-CoA kinase.Dephospho-CoA kinasePantothenate and CoA biosynthesis	3
3.40.50.300.178	2grjA00	Thermotoga maritimaDephospho-CoA kinase [EC:2.7.1.24]Dephospho-CoA kinase.Pantothenate and CoA biosynthesisDephospho-CoA kinase	8
3.40.50.300.179	2ph1A00	Archaeoglobus fulgidusNucleotide-binding protein	1
3.40.50.300.180	1darA01	Elongation factor GThermus thermophilus HB8Elongation factor EF-G [EC:3.6.5.3]	12
3.40.50.300.181	1gkuB03	Reverse gyraseReverse gyrase [EC:5.99.1.3 3.6.1.-]In phosphorous-containing anhydrides.Archaeoglobus fulgidusDNA topoisomerase (ATP-hydrolyzing).	3
3.40.50.300.182	1xjcA00	Geobacillus stearothermophilusMobB protein homolog	1
3.40.50.300.183	2gnoA01	Pyrimidine metabolismThermotoga maritimaDNA replicationPurine metabolismDNA polymerase III, gamma subunit-related protein	1
3.40.50.300.184	3kqnA01	RNA-directed RNA polymerase.Hepatitis C virus (isolate Con1)In phosphorous-containing anhydrides.Genome polyproteinNucleoside-triphosphatase.	23
3.40.50.300.185	1tf7A01	Non-specific serine/threonine protein kinase.Circadian clock protein KaiCCircadian clock protein kinase kaiCIdentical protein bindingEntrainment of circadian clock	14
3.40.50.300.186	1kjwA02	Postsynaptic membraneRattus norvegicusProtein C-terminus bindingIonotropic glutamate receptor bindingDisks large homolog 4	4
3.40.50.300.187	3kqnA02	Hepatitis C virus (isolate Con1)RNA-directed RNA polymerase.In phosphorous-containing anhydrides.Genome polyproteinCysteine endopeptidases.	25
3.40.50.300.188	1e2kA00	Herpes simplex virus (type 1 / strain 17)Thymidine kinaseThymidine kinase.	59
3.40.50.300.189	3czqC00	Sinorhizobium melilotiPutative uncharacterized protein	4
3.40.50.300.190	1p9rA02	General secretion pathway protein EVibrio choleraeBacterial secretion systemGeneral secretion pathway protein E	2
3.40.50.300.191	2akaB00	Identical protein bindingDynamin GTPase.Rattus norvegicusReceptor internalizationProtein complex binding	3
3.40.50.300.192	2if2A00	Dephospho-CoA kinase [EC:2.7.1.24]Dephospho-CoA kinase.Pantothenate and CoA biosynthesisDephospho-CoA kinaseMetabolic pathways	3
3.40.50.300.193	3d31A01	Methanosarcina acetivoransPutative sulfate transport system ATP-binding proteinSulfate/molybdate ABC transporter, ATP-binding proteinABC transporters	6
3.40.50.300.194	1vcnA01	Pyrimidine metabolismThermus thermophilus HB8CTP synthase.CTP synthaseCTP synthase [EC:6.3.4.2]	7
3.40.50.300.195	3do6A01	Thermotoga maritimaOne carbon pool by folateFormate--tetrahydrofolate ligase [EC:6.3.4.3]Formate--tetrahydrofolate ligaseFormate--tetrahydrofolate ligase.	8
3.40.50.300.196	1g8fA03	Selenoamino acid metabolismIdentical protein bindingPurine metabolismSulfur metabolismSulfate adenylyltransferase (ATP) activity	13
3.40.50.300.197	1odfA00	ATP bindingCytoplasmUncharacterized kinase YGR205WTransferring phosphorous-containing groups.Nucleus	1
3.40.50.300.198	1u9iA02	Circadian clock protein KaiCNon-specific serine/threonine protein kinase.Circadian clock protein kinase kaiCIdentical protein bindingEntrainment of circadian clock	14
3.40.50.300.199	2r6fA05	Nucleotide excision repairGeobacillus kaustophilusExcinuclease ABC subunit AExcinuclease ABC subunit A	2
3.40.50.300.200	1wb1C01	Methanococcus maripaludisMJ0495-like protein	12
3.40.50.300.201	2x19A00	Exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)NucleusNucleus organizationNucleocytoplasmic transportProtein binding	3
3.40.50.300.202	1ihuA02	Escherichia coliArsenical pump-driving ATPaseArsenite-transporting ATPase.	6
3.40.50.300.203	1gm5A04	Thermotoga maritimaHomologous recombinationATP-dependent DNA helicase RecG [EC:3.6.1.-]ATP-dependent DNA helicase	1
3.40.50.300.204	1nstA00	Glycosaminoglycan biosynthesis - heparan sulfateHydrolases.Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1Heparan sulfate proteoglycan biosynthetic processHeparan sulfate N-deacetylase/N-sulfotransferase NDST1 [EC:3.1.1.- 2.8.2.-]	1
3.40.50.300.205	1l8qA01	Two-component systemChromosomal replication initiator proteinChromosomal replication initiator protein dnaAAquifex aeolicus	9
3.40.50.300.206	1dekA01	Deoxynucleotide monophosphate kinaseEnterobacteria phage T4(Deoxy)nucleoside-phosphate kinase.	4
3.40.50.300.207	1w36D02	DNA recombinationExodeoxyribonuclease V.Protein bindingEscherichia coli K-12Exodeoxyribonuclease V alpha subunit [EC:3.1.11.5]	4
3.40.50.300.208	1ofuX00	Pseudomonas aeruginosaCell division inhibitor SulACell division inhibitor sulA	6
3.40.50.300.209	1znwA01	Purine metabolismGuanylate kinaseGuanylate kinase [EC:2.7.4.8]Guanylate kinase.Metabolic pathways	6
3.40.50.300.210	1a7jA00	Phosphoribulokinase.Rhodobacter sphaeroidesPhosphoribulokinase 1	1
3.40.50.300.211	1sq5C00	Pantothenate kinaseCoenzyme A biosynthetic processPantothenate kinase.Escherichia coli K-12Metabolic pathways	30
3.40.50.300.212	1jqlB00	Pyrimidine metabolismDNA replicationPurine metabolismProtein bindingMetabolic pathways	6
3.40.50.300.213	1zakA00	Adenylate kinase, chloroplasticAdenylate kinase.Zea mays	2
3.40.50.300.214	3co5A00	Neisseria gonorrhoeae FA 1090Putative two-component system transcriptional response regulator	2
3.40.50.300.215	1w36D03	DNA recombinationExodeoxyribonuclease V.Protein bindingEscherichia coli K-12Exodeoxyribonuclease V alpha subunit [EC:3.1.11.5]	4
3.40.50.300.216	1w36B01	ATP bindingHomologous recombinationExodeoxyribonuclease V beta chainExodeoxyribonuclease V beta subunit [EC:3.1.11.5]Exodeoxyribonuclease V.	4
3.40.50.300.217	1sxjE01	Leading strand elongationNucleotide excision repairDNA replicationReplication factor C subunit 3/5Protein binding	1
3.40.50.300.218	1lw7A02	Haemophilus influenzaeTranscriptional regulator nadRHipB family transcriptional regulator, involved in the regulation of NAD biosynthesis	1
3.40.50.300.219	2zejB02	Non-specific serine/threonine protein kinase.MAP kinase kinase activityDetermination of adult lifespanExternal side of mitochondrial outer membraneLeucine-rich repeat serine/threonine-protein kinase 2	2
3.40.50.300.220	1zp6A00	Agrobacterium tumefaciens str. C58Putative uncharacterized protein	1
3.40.50.300.221	1e9rD01	TrwBEscherichia coli	36
3.40.50.300.222	3h0kA00	Sulfolobus solfataricusUPF0200 protein SSO1041	2
3.40.50.300.223	1nktA01	Protein exportBacterial secretion systemProtein translocase subunit secA 1Mycobacterium tuberculosisPreprotein translocase subunit SecA	2
3.40.50.300.224	1pv4E02	Transcriptional attenuationRNA degradationIn phosphorous-containing anhydrides.Protein bindingTranscription termination factor Rho	30
3.40.50.300.225	1e69A00	Thermotoga maritimaChromosome segregation SMC protein, putativeChromosome segregation protein	6
3.40.50.300.226	1gm5A05	Thermotoga maritimaHomologous recombinationATP-dependent DNA helicase RecG [EC:3.6.1.-]ATP-dependent DNA helicase	1
3.40.50.300.227	1fmjA00	Retinol dehydrataseSpodoptera frugiperda	10
3.40.50.300.228	1w36B03	ATP bindingHomologous recombinationExodeoxyribonuclease V beta chainExodeoxyribonuclease V beta subunit [EC:3.1.11.5]Exodeoxyribonuclease V.	4
3.40.50.300.229	2pjrA03	Geobacillus stearothermophilusIn phosphorous-containing anhydrides.ATP-dependent DNA helicase pcrA	2
3.40.50.300.230	1osnC00	Thymidine kinaseHuman herpesvirus 3 strain Oka vaccineThymidine kinase.	4

Close Structural Clusters (54)
Distant Structural Clusters (25)

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

Close Structural Clusters 3.40.50.300 (< 5Å)

Summary of "distant" structural clusters found within this level of CATH.
Cluster ID	Example Domain	Domains in Cluster	Structural Alignment (Core)	Structural Alignment (Expanded)
00003.00040.00050.00300/SSG5/1	2bjwA01	7	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSG5/2	3czpA02	2	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSG5/3	1cp2A00	2	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSG5/4	1nlfA00	2	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSG5/5	1d2nA01	4	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSG5/6	1dekA01	2	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSG5/7	1e2kA00	2	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSG5/8	1viaA00	3	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSG5/9	1f6bB00	3	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSG5/10	2reoA01	4	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSG5/11	1gkuB03	5	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSG5/12	3ea0A00	3	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSG5/13	1um8A01	3	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSG5/14	1g6hA00	8	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSG5/15	1n0uA01	3	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSG5/16	1xwiA01	3	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSG5/17	1gm5A05	2	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSG5/18	4tmkA00	4	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSG5/19	1ihuA02	2	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSG5/20	1zunB01	2	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSG5/21	1kgdA01	5	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSG5/22	1qhxA00	5	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSG5/23	1knqA00	3	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSG5/24	1knxE02	2	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSG5/25	1lw7A02	2	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSG5/26	1z2aA00	13	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSG5/27	1mkyA01	2	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSG5/28	1n0wA00	2	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSG5/29	3cx8A01	6	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSG5/30	2qm8A02	2	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSG5/31	1xjcA00	2	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSG5/32	1nrjB00	2	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSG5/33	1p9rA02	2	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSG5/34	3b85A00	3	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSG5/35	2qmoA00	2	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSG5/36	1pujA01	2	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSG5/37	2gxqA00	4	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSG5/38	1zd1B00	2	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSG5/39	3dl0A00	5	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSG5/40	1rz3A00	3	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSG5/41	2qi9C00	5	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSG5/42	1svmA03	2	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSG5/43	1t0jB00	2	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSG5/44	2hxsA00	4	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSG5/45	1u9iA02	3	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSG5/46	2qu8A00	2	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSG5/47	1vhtA00	5	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSG5/48	1vecA00	3	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSG5/49	1vmaA02	2	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSG5/50	1rifA02	4	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSG5/51	2ck3D02	2	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSG5/52	2g0tA02	2	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSG5/53	3dmnA00	2	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSG5/54	2vp4D00	2	FASTA Jalview	FASTA Jalview

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

Distant Structural Clusters 3.40.50.300 (< 9Å)

Summary of "distant" structural clusters found within this level of CATH.
Cluster ID	Example Domain	Domains in Cluster	Structural Alignment (Core)	Structural Alignment (Expanded)
00003.00040.00050.00300/SSGA9/1	1uj2A00	3	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSGA9/2	1sgwA00	4	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSGA9/3	1fnnA02	5	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSGA9/4	2r44A02	3	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSGA9/5	2r8rA00	2	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSGA9/6	1vytB02	4	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSGA9/7	2rhmC00	11	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSGA9/8	1mkyA02	2	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSGA9/9	1udxA02	4	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSGA9/10	1nktA01	2	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSGA9/11	1nrjB00	6	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSGA9/12	1texA00	3	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSGA9/13	3co5A00	2	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSGA9/14	1pv4E02	2	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSGA9/15	1byiA00	4	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSGA9/16	3kqnA01	5	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSGA9/17	3crmA01	5	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSGA9/18	2jgnB00	4	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSGA9/19	1zd1B00	2	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSGA9/20	2xb4A00	3	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSGA9/21	1c4oA03	2	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSGA9/22	2w58B01	6	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSGA9/23	3kb2A00	3	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSGA9/24	1n0wA00	4	FASTA Jalview	FASTA Jalview
00003.00040.00050.00300/SSGA9/25	2dbyA01	4	FASTA Jalview	FASTA Jalview

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

Structural Comparisons for Non-redundant S35 Representatives of 3.40.50.300 ( entries)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

Homologous Superfamily: 3.40.50.300

P-loop containing nucleotide triphosphate hydrolases

Classification Lineage (3.40.50.300)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S35 Family Entries in Homologous Superfamily 3.40.50.300 (230)

What is an Close Structural Cluster?

Close Structural Clusters 3.40.50.300 (< 5Å)

What is a Distant Structural Cluster?

Distant Structural Clusters 3.40.50.300 (< 9Å)

What is a Structural Neighbour?

Structural Comparisons for Non-redundant S35 Representatives of 3.40.50.300 ( entries)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

CATH Shortcuts