Homologous Superfamily: 2.30.30.40

Molscript image for 2o9sA00
Representative domain: 2o9sA00
PDB coordinates for domain 2o9sA00

SH3 Domains

Classification Lineage (2.30.30.40)

CATH CodeLevel DescriptionLinks
2 Mainly Beta
2.30 Roll
2.30.30 SH3 type barrels.
2.30.30.40 SH3 Domains Gene3D

Summary of Non-Redundant Representatives
- - - - 65 94 128 169 386

S35 Family Entries in Homologous Superfamily 2.30.30.40 (65)

CATH Level CATH code Representative Domain Representative Keywords Representative Thumbnail Number of Domains
2.30.30.40.1 2o9sA00 Sorbin and SH3 domain containing 1PPAR signaling pathwayInsulin signaling pathwayNucleusZonula adherens Molscript image for 2o9sA00 4
2.30.30.40.2 2iimA00 Pericentriolar materialPhosphoinositide 3-kinase bindingCD8 receptor bindingT cell receptor signaling pathwayCD4 receptor binding Molscript image for 2iimA00 56
2.30.30.40.3 1g2bA00 Molscript image for 1g2bA00 2
2.30.30.40.4 1wyxA00 RuffleMembrane fractionIntegrin-mediated signaling pathwayActin filament organizationB cell receptor signaling pathway Molscript image for 1wyxA00 3
2.30.30.40.5 1y0mA00 Calcium signaling pathwayPhosphatidylinositol signaling systemRattus norvegicusPathways in cancerPhospholipase C, gamma [EC:3.1.4.11] Molscript image for 1y0mA00 13
2.30.30.40.6 1zlmA00 Osteoclast-stimulating factor 1OssificationIdentical protein bindingHomo sapiensSignal transduction Molscript image for 1zlmA00 10
2.30.30.40.7 2v1qA00 Actin cortical patch assemblyIdentical protein bindingMating projection tipNucleusActin filament organization Molscript image for 2v1qA00 5
2.30.30.40.8 3eg3A00 DNA damage response, signal transduction resulting in induction of apoptosisProto-oncogene tyrosine-protein kinase ABL1 [EC:2.7.10.2]Pathways in cancerNucleolusNeurotrophin signaling pathway Molscript image for 3eg3A00 19
2.30.30.40.9 2hbwA01 Anabaena variabilis ATCC 29413NLP/P60 Molscript image for 2hbwA01 4
2.30.30.40.10 1sshA00 Cellular bud neckIdentical protein bindingActin cortical patch localizationSaccharomyces cerevisiaeMitochondrion Molscript image for 1sshA00 12
2.30.30.40.11 1jo8A00 Actin cortical patch assemblyActin-binding proteinMating projection tipEstablishment of cell polarityProtein localization Molscript image for 1jo8A00 11
2.30.30.40.12 1w70A00 Protein dimerization activityNeutrophil cytosolic factor 4Leukocyte transendothelial migrationCytosolNADPH oxidase complex Molscript image for 1w70A00 5
2.30.30.40.13 1zuyA00 Mating projection tipIdentical protein bindingActin cortical patch localizationReceptor-mediated endocytosisResponse to salt stress Molscript image for 1zuyA00 9
2.30.30.40.14 3i35A00 Focal adhesionHomo sapiensLIM and SH3 domain protein 1SH3/SH2 adaptor activity Molscript image for 3i35A00 3
2.30.30.40.15 3h0hA00 Prion diseasesFeeding behaviorLearningTyrosine-protein kinase FynT cell receptor signaling pathway Molscript image for 3h0hA00 5
2.30.30.40.16 3i9qA00 Spectrin alpha chain, brainGallus gallusSpectrin alpha Molscript image for 3i9qA00 24
2.30.30.40.17 2ak5B00 CytoplasmRattus norvegicusAstrocyte cell migrationFocal adhesionRho guanine nucleotide exchange factor 7 Molscript image for 2ak5B00 8
2.30.30.40.18 1ckaA00 Pathways in cancerChemokine signaling pathwayNeurotrophin signaling pathwayFc gamma R-mediated phagocytosisErbB signaling pathway Molscript image for 1ckaA00 9
2.30.30.40.19 1ng2A02 Soluble fractionGTP bindingCellular defense responseSH3 domain bindingSuperoxide anion generation Molscript image for 1ng2A02 2
2.30.30.40.20 1gcqC00 Positive regulation of cell adhesionMus musculusT cell differentiationRac guanyl-nucleotide exchange factor activityIntegrin-mediated signaling pathway Molscript image for 1gcqC00 6
2.30.30.40.21 1yn8A00 Hyperosmotic responseNucleusResponse to heatNegative regulation of protein kinase activityProtein binding Molscript image for 1yn8A00 7
2.30.30.40.22 2vwfA00 Jak-STAT signaling pathwayNeurotrophin signaling pathwayNon-small cell lung cancerT cell receptor signaling pathwayErbB signaling pathway Molscript image for 2vwfA00 20
2.30.30.40.23 2j6fA00 RufflePlasma membraneSH3 domain bindingStructural constituent of cytoskeletonProtein complex assembly Molscript image for 2j6fA00 18
2.30.30.40.24 3ehrB01 OssificationOsteoclast-stimulating factor 1Identical protein bindingHomo sapiensSignal transduction Molscript image for 3ehrB01 4
2.30.30.40.25 1i07A00 Adult locomotory behaviorActin cytoskeleton reorganizationProtein bindingBehavioral response to ethanolMus musculus Molscript image for 1i07A00 8
2.30.30.40.26 2vknA00 MAPK signaling pathway - yeastIdentical protein bindingMating projection tipPseudohyphal growthSHO1 osmosensor Molscript image for 2vknA00 3
2.30.30.40.27 1tucA00 Spectrin alpha chain, brainGallus gallusSpectrin alpha Molscript image for 1tucA00 1
2.30.30.40.28 1ycsB02 Induction of apoptosisNF-kappaB bindingNegative regulation of cell cycleApoptosis-stimulating of p53 protein 2Homo sapiens Molscript image for 1ycsB02 1
2.30.30.40.29 2v1rA00 PeroxisomePeroxin-13Protein binding, bridgingPeroxisomal membrane protein PAS20Peroxisomal membrane Molscript image for 2v1rA00 8
2.30.30.40.30 1ov3A01 GTP bindingSoluble fractionCellular defense responseSH3 domain bindingSuperoxide anion generation Molscript image for 1ov3A01 2
2.30.30.40.31 1ov3A02 Soluble fractionGTP bindingCellular defense responseSH3 domain bindingSuperoxide anion generation Molscript image for 1ov3A02 3
2.30.30.40.32 3i5rA00 ErbB-3 class receptor bindingInsulin-like growth factor receptor signaling pathwayInsulin receptor signaling pathwayGrowth hormone receptor signaling pathwayInsulin-like growth factor receptor binding Molscript image for 3i5rA00 11
2.30.30.40.33 2ablA01 DNA damage response, signal transduction resulting in induction of apoptosisProto-oncogene tyrosine-protein kinase ABL1 [EC:2.7.10.2]Pathways in cancerNeurotrophin signaling pathwayNucleolus Molscript image for 2ablA01 2
2.30.30.40.34 1ad5A01 Protein phosphorylationTyrosine-protein kinase HCKMesoderm developmentHomo sapiensProtein binding Molscript image for 1ad5A01 9
2.30.30.40.35 1ng2A01 GTP bindingSoluble fractionCellular defense responseSH3 domain bindingSuperoxide anion generation Molscript image for 1ng2A01 2
2.30.30.40.36 1b3qB03 Thermotoga maritimaBacterial chemotaxisTwo-component systemHistidine kinase.Two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3] Molscript image for 1b3qB03 3
2.30.30.40.37 1jxmA01 Postsynaptic membraneRattus norvegicusProtein C-terminus bindingIonotropic glutamate receptor bindingDisks large homolog 4 Molscript image for 1jxmA01 4
2.30.30.40.38 1bb9A00 Rattus norvegicusProtein heterodimerization activitySynaptic vesicle endocytosisProtein C-terminus bindingMyc box-dependent-interacting protein 1 Molscript image for 1bb9A00 4
2.30.30.40.39 1i1jB00 Melanoma-derived growth regulatory proteinHomo sapiensExtracellular spaceCell proliferation Molscript image for 1i1jB00 4
2.30.30.40.40 1t0hA00 Calcium channel regulator activityRattus norvegicusVoltage-dependent L-type calcium channel subunit beta-2Calcium ion transportVoltage-gated calcium channel complex Molscript image for 1t0hA00 8
2.30.30.40.41 2ch4Y01 Purine-binding chemotaxis protein CheWThermotoga maritimaBacterial chemotaxisTwo-component systemChemotaxis protein cheW Molscript image for 2ch4Y01 3
2.30.30.40.42 1griA01 Jak-STAT signaling pathwayNeurotrophin signaling pathwayNon-small cell lung cancerT cell receptor signaling pathwayErbB signaling pathway Molscript image for 1griA01 8
2.30.30.40.43 1vytA01 Cardiac muscle contractionRattus norvegicusVoltage-gated calcium channel complexDilated cardiomyopathyCalcium channel, voltage-dependent, beta 3 subunit Molscript image for 1vytA01 2
2.30.30.40.44 1x6bA01 Rho guanine nucleotide exchange factor 16Homo sapiens Molscript image for 1x6bA01 1
2.30.30.40.45 2jteA00 Mus musculusCD2-associated protein Molscript image for 2jteA00 3
2.30.30.40.46 2csqA01 RIMS-binding protein 2Homo sapiens Molscript image for 2csqA01 1
2.30.30.40.47 2js2A00 Receptor bindingNCK adaptor proteinPositive regulation of T cell proliferationT cell receptor signaling pathwayPositive regulation of actin filament polymerization Molscript image for 2js2A00 3
2.30.30.40.48 1wx6A01 NCK adaptor proteinPositive regulation of T cell proliferationRegulation of epidermal growth factor receptor activityT cell receptor signaling pathwayEpidermal growth factor receptor signaling pathway Molscript image for 1wx6A01 3
2.30.30.40.49 1u3oA01 Non-specific serine/threonine protein kinase.Rattus norvegicusVesicle-mediated transportAxonogenesisProtein binding Molscript image for 1u3oA01 1
2.30.30.40.50 1awwA00 Induction of apoptosis by extracellular signalsIdentical protein bindingPhosphatidylinositol-3,4,5-trisphosphate bindingPlasma membraneB cell receptor signaling pathway Molscript image for 1awwA00 4
2.30.30.40.51 2ke9A00 Caskin-2Homo sapiens Molscript image for 2ke9A00 1
2.30.30.40.52 2rqtA00 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing proteinArf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1Fc gamma R-mediated phagocytosisHomo sapiensProtein binding Molscript image for 2rqtA00 2
2.30.30.40.53 1jegA00 Tyrosine-protein kinase CSKProtein bindingCell-cell junctionATP bindingMus musculus Molscript image for 1jegA00 6
2.30.30.40.54 1uhfA00 Intersectin-2Homo sapiensSH3/SH2 adaptor activity Molscript image for 1uhfA00 2
2.30.30.40.55 1spkA00 Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1Mus musculus Molscript image for 1spkA00 2
2.30.30.40.56 2aklA02 Pseudomonas aeruginosaPhosphonoacetate hydrolase [EC:3.11.1.2]Phosphonate and phosphinate metabolismPutative uncharacterized protein Molscript image for 2aklA02 2
2.30.30.40.57 1j3tA00 Intersectin-2Homo sapiensSH3/SH2 adaptor activity Molscript image for 1j3tA00 2
2.30.30.40.58 2heqA01 Bacillus subtilisSPBc2 prophage-derived uncharacterized protein yorP Molscript image for 2heqA01 1
2.30.30.40.59 2o2oA00 NucleusHomo sapiensSH3 domain-containing kinase-binding protein 1 Molscript image for 2o2oA00 1
2.30.30.40.60 2epdA00 Rho protein signal transductionCytoskeleton organizationRho GTPase-activating protein 4Homo sapiensRho GTPase activator activity Molscript image for 2epdA00 1
2.30.30.40.61 1awjA00 Mus musculusTyrosine-protein kinase ITK/TSKNon-specific protein-tyrosine kinase.Protein binding Molscript image for 1awjA00 1
2.30.30.40.62 1ri9A00 FYN-binding proteinNucleusProtein bindingNLS-bearing substrate import into nucleusProtein phosphorylation Molscript image for 1ri9A00 1
2.30.30.40.63 1ug1A00 Dynamin-binding proteinHomo sapiensProtein binding Molscript image for 1ug1A00 1
2.30.30.40.64 1uffA00 Intersectin-2Homo sapiensSH3/SH2 adaptor activity Molscript image for 1uffA00 1
2.30.30.40.65 1udlA00 Intersectin-2Homo sapiensSH3/SH2 adaptor activity Molscript image for 1udlA00 1

Close Structural Clusters 2.30.30.40 (< 5Å)

Summary of "distant" structural clusters found within this level of CATH.
Cluster ID Example Domain Domains in Cluster Structural Alignment (Core) Structural Alignment (Expanded)
00002.00030.00030.00040/SSG5/1 1ad5A01 8
00002.00030.00030.00040/SSG5/2 1ov3A01 2
00002.00030.00030.00040/SSG5/3 1ri9A00 2
00002.00030.00030.00040/SSG5/4 1t0hA00 2
00002.00030.00030.00040/SSG5/5 2heqA01 5
00002.00030.00030.00040/SSG5/6 2j6fA00 16
00002.00030.00030.00040/SSG5/7 2ch4Y01 2
00002.00030.00030.00040/SSG5/8 1jxmA01 2
00002.00030.00030.00040/SSG5/9 1x6bA01 14
00002.00030.00030.00040/SSG5/10 1u3oA01 5


Distant Structural Clusters 2.30.30.40 (< 9Å)

Summary of "distant" structural clusters found within this level of CATH.
Cluster ID Example Domain Domains in Cluster Structural Alignment (Core) Structural Alignment (Expanded)
00002.00030.00030.00040/SSGA9/1 2v1qA00 6
00002.00030.00030.00040/SSGA9/2 1bb9A00 2
00002.00030.00030.00040/SSGA9/3 1i1jB00 2
00002.00030.00030.00040/SSGA9/4 1u3oA01 3
00002.00030.00030.00040/SSGA9/5 1uffA00 2


Structural Comparisons for Non-redundant S35 Representatives of 2.30.30.40 ( entries)