CATH Classification

Domain Context

CATH Clusters

Superfamily Aldolase class I
Functional Family KHG/KDPG aldolase

Enzyme Information

4.1.3.16
4-hydroxy-2-oxoglutarate aldolase.
based on mapping to UniProt P0A955
4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate.
-!- The enzymes from rat liver and bovine liver act on both enantiomers of 4-hydroxy-2-oxoglutarate. -!- Formerly EC 4.1.2.1 and EC 4.1.2.31.
4.1.2.14
2-dehydro-3-deoxy-phosphogluconate aldolase.
based on mapping to UniProt P0A955
2-dehydro-3-deoxy-6-phosphate-D-gluconate = pyruvate + D-glyceraldehyde 3-phosphate.
-!- The enzyme shows no activity with 2-dehydro-3-deoxy-6-phosphate-D- galactonate (cf. EC 4.1.2.55). -!- Also acts on 2-oxobutanoate.

UniProtKB Entries (1)

P0A955
ALKH_ECOLI
Escherichia coli K-12
KHG/KDPG aldolase

PDB Structure

PDB 2C0A
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Mechanism of the Class I Kdpg Aldolase.
Fullerton, S.W.B., Griffiths, J.S., Merkel, A.B., Cheriyann, M., Wymer, J., Hutchins, M.J., Fierke, C.A., Toone, E.J., Naismith, J.H.
Bioorg.Med.Chem.