CATH Classification

Domain Context

CATH Clusters

Superfamily Aldolase class I
Functional Family 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, chloroplastic

Enzyme Information

5.3.1.16
1-(5-phosphoribosyl)-5- ((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase.
based on mapping to UniProt P40545
1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D- ribosylamino)methylideneamino)imidazole-4-carboxamide = 5-((5-phospho-1- deoxy-D-ribulos-1-ylamino)methylideneamino)-1-(5-phospho-beta-D- ribosyl)imidazole-4-carboxamide.
-!- Involved in histidine biosynthesis.

UniProtKB Entries (1)

P40545
HIS4_YEAST
Saccharomyces cerevisiae S288C
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

PDB Structure

PDB 2AGK
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of the yeast His6 enzyme suggests a reaction mechanism
Quevillon-Cheruel, S., Leulliot, N., Graille, M., Blondeau, K., Janin, J., Tilbeurgh, H.V.
Protein Sci.