CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
Functional Family Protein kinase C

Enzyme Information

2.7.11.13
Protein kinase C.
based on mapping to UniProt P41743
ATP + a protein = ADP + a phosphoprotein.
-!- A family of serine- and threonine-specific protein kinases that depend on lipids for activity. -!- They can be activated by calcium but have a requirement for the second messenger diacylglycerol. -!- Members of this group of enzymes phosphorylate a wide variety of protein targets and are known to be involved in diverse cell- signaling pathways. -!- Members of the protein kinase C family also serve as major receptors for phorbol esters, a class of tumor promoters. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P41743
KPCI_HUMAN
Homo sapiens
Protein kinase C iota type

PDB Structure

PDB 1WMH
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure of a Cell Polarity Regulator, a Complex between Atypical PKC and Par6 PB1 Domains
Hirano, Y., Yoshinaga, S., Takeya, R., Suzuki, N.N., Horiuchi, M., Kohjima, M., Sumimoto, H., Inagaki, F.
J.Biol.Chem.