CATH Classification

Domain Context

CATH Clusters

Superfamily Glycosidases
Functional Family Endochitinase B1

Enzyme Information

3.2.1.14
Chitinase.
based on mapping to UniProt E9QRF2
Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta- linkages in chitin and chitodextrins.
-!- The enzyme binds to chitin and randomly cleaves glycosidic linkages in chitin and chitodextrins in a non-processive mode, generating chitooligosaccharides and free ends on which exo-chitinases and exo- chitodextrinases can act. -!- Activity is greatly stimulated in the presence of EC 1.14.99.53, which attacks the crystalline structure of chitin and makes the polymer more accesible to the chitinase. -!- Cf. EC 3.2.1.202.

UniProtKB Entries (1)

E9QRF2
CHIB1_ASPFU
Aspergillus fumigatus Af293
Endochitinase B1

PDB Structure

PDB 1W9V
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Specificity and Affinity of Natural Product Cyclopentapeptide Inhibitors Against Aspergillus Fumigatus, Human and Bacterial Chitinases
Rao, F.V., Houston, D.R., Boot, R.G., Aerts, J.M.F.G., Hodkinson, M., Adams, D.J., Shiomi, K., Omura, S., Van Aalten, D.M.F.
Chem.Biol.