CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Prothrombin

Enzyme Information

3.4.21.5
Thrombin.
based on mapping to UniProt P00734
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
-!- More selective than trypsin and plasmin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.13.

UniProtKB Entries (1)

P00734
THRB_HUMAN
Homo sapiens
Prothrombin

PDB Structure

PDB 1NRR
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystallographic structures of thrombin complexed with thrombin receptor peptides: existence of expected and novel binding modes.
Mathews, I.I., Padmanabhan, K.P., Ganesh, V., Tulinsky, A., Ishii, M., Chen, J., Turck, C.W., Coughlin, S.R., Fenton 2nd., J.W.
Biochemistry