CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.2300
Functional Family Arsenate reductase

Enzyme Information

1.20.4.4
Arsenate reductase (thioredoxin).
based on mapping to UniProt P0A006
Arsenate + thioredoxin = arsenite + thioredoxin disulfide + H(2)O.
-!- The enzyme, characterized in bacteria of the Firmicutes phylum, is specific for thioredoxin. -!- It has no activity with glutaredoxin (cf. EC 1.20.4.1). -!- Although the arsenite formed is more toxic than arsenate, it can be extruded from some bacteria by EC 7.3.2.7; in other organisms, arsenite can be methylated by EC 2.1.1.137 in a pathway that produces non-toxic organoarsenical compounds. -!- The enzyme also has the activity of EC 3.1.3.48.

UniProtKB Entries (1)

P0A006
ARSC_STAAU
Staphylococcus aureus
Arsenate reductase

PDB Structure

PDB 1LJL
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
All intermediates of the arsenate reductase mechanism, including an intramolecular dynamic disulfide cascade.
Messens, J., Martins, J.C., Van Belle, K., Brosens, E., Desmyter, A., De Gieter, M., Wieruszeski, J.M., Willem, R., Wyns, L., Zegers, I.
Proc.Natl.Acad.Sci.USA