Homologous Superfamily: 3.40.50.2300

Molscript image for 2fvyA01
Representative domain: 2fvyA01
PDB coordinates for domain 2fvyA01

Classification Lineage (3.40.50.2300)

CATH CodeLevel DescriptionLinks
3 Alpha Beta
3.40 3-Layer(aba) Sandwich
3.40.50 Rossmann fold
3.40.50.2300 Gene3D

Summary of Non-Redundant Representatives
- - - - 112 133 153 334 752

S35 Family Entries in Homologous Superfamily 3.40.50.2300 (112)

CATH Level CATH code Representative Domain Representative Keywords Representative Thumbnail Number of Domains
3.40.50.2300.1 2fvyA01 Methyl-galactoside transport system substrate-binding proteinBacterial chemotaxisD-galactose-binding periplasmic proteinABC transportersEscherichia coli K-12 Molscript image for 2fvyA01 14
3.40.50.2300.2 2fvyA02 Methyl-galactoside transport system substrate-binding proteinBacterial chemotaxisD-galactose-binding periplasmic proteinEscherichia coli K-12ABC transporters Molscript image for 2fvyA02 14
3.40.50.2300.3 1jbeA00 Escherichia coli O157:H7Two-component system, chemotaxis family, response regulator CheYBacterial chemotaxisTwo-component systemChemotaxis protein cheY Molscript image for 1jbeA00 93
3.40.50.2300.4 3ckmA02 Haemophilus influenzaeUncharacterized protein HI_1655 Molscript image for 3ckmA02 2
3.40.50.2300.5 3lftB01 Putative ABC transport system substrate-binding proteinPutative uncharacterized proteinStreptococcus pneumoniae Molscript image for 3lftB01 3
3.40.50.2300.6 3lftA02 Putative ABC transport system substrate-binding proteinPutative uncharacterized proteinStreptococcus pneumoniae Molscript image for 3lftA02 3
3.40.50.2300.7 3ctpA02 Alkaliphilus metalliredigens QYMFPeriplasmic binding protein/LacI transcriptional regulator Molscript image for 3ctpA02 2
3.40.50.2300.8 8abpA01 L-arabinose-binding periplasmic proteinL-arabinose transport system substrate-binding proteinABC transportersEscherichia coli K-12 Molscript image for 8abpA01 12
3.40.50.2300.9 1usgA02 Leucine-specific-binding proteinBranched-chain amino acid transport system substrate-binding proteinEscherichia coli K-12ABC transporters Molscript image for 1usgA02 13
3.40.50.2300.10 1s8nA01 Response regulator NasTProbable transcriptional regulatory protein pdtaRMycobacterium tuberculosis Molscript image for 1s8nA01 9
3.40.50.2300.11 3ctpA01 Alkaliphilus metalliredigens QYMFPeriplasmic binding protein/LacI transcriptional regulator Molscript image for 3ctpA01 2
3.40.50.2300.12 1qkkA00 Sinorhizobium melilotiTwo-component systemTwo-component system, NtrC family, C4-dicarboxylate transport response regulator DctDC4-dicarboxylate transport transcriptional regulatory protein dctD Molscript image for 1qkkA00 10
3.40.50.2300.13 1jyeA02 Lactose operon repressorProtein bindingCytosolEscherichia coli K-12 Molscript image for 1jyeA02 31
3.40.50.2300.14 1gudA01 MembraneD-allose transport system substrate-binding proteinD-allose-binding periplasmic proteinEscherichia coli K-12ABC transporters Molscript image for 1gudA01 4
3.40.50.2300.15 2driA02 D-ribose-binding periplasmic proteinBacterial chemotaxisRibose transport system substrate-binding proteinMembraneABC transporters Molscript image for 2driA02 15
3.40.50.2300.16 1jx6A02 Vibrio harveyiVibrio cholerae pathogenic cycleAutoinducer 2-binding periplasmic protein LuxPProtein bindingAutoinducer 2-binding periplasmic protein luxP Molscript image for 1jx6A02 4
3.40.50.2300.17 2jbaA00 Phosphate regulon transcriptional regulatory protein phoBTwo-component systemTwo-component system, OmpR family, phosphate regulon response regulator PhoBProtein bindingEscherichia coli K-12 Molscript image for 2jbaA00 35
3.40.50.2300.18 2qvgA00 Phosphotransferases with a nitrogenous group as acceptor.Two component response regulator[EC:2.7.3.-]Legionella pneumophila subsp. pneumophila str. Philadelphia 1 Molscript image for 2qvgA00 1
3.40.50.2300.19 2r25B00 MAPK signaling pathway - yeastResponse to hydrogen peroxideProtein bindingOsomolarity two-component system, sensor histidine kinase SLN1 [EC:2.7.13.3]Osmosensor activity Molscript image for 2r25B00 8
3.40.50.2300.20 2h3hA01 Thermotoga maritimaSugar ABC transporter, periplasmic sugar-binding proteinSimple sugar transport system substrate-binding protein Molscript image for 2h3hA01 10
3.40.50.2300.21 1k68A00 Tolypothrix sp. PCC 7601Response regulator Molscript image for 1k68A00 8
3.40.50.2300.22 1jyeA01 Lactose operon repressorProtein bindingEscherichia coli K-12Cytosol Molscript image for 1jyeA01 31
3.40.50.2300.23 2r47A01 Methanothermobacter thermautotrophicus str. Delta HUncharacterized protein MTH_862 Molscript image for 2r47A01 5
3.40.50.2300.24 1dbwB00 Transcriptional regulatory protein fixJSinorhizobium meliloti Molscript image for 1dbwB00 11
3.40.50.2300.25 2driA01 D-ribose-binding periplasmic proteinMembraneBacterial chemotaxisRibose transport system substrate-binding proteinEscherichia coli K-12 Molscript image for 2driA01 11
3.40.50.2300.26 1mb3A00 Caulobacter vibrioidesTwo-component systemTwo-component system, cell cycle response regulator DivKPolar differentiation response regulatorCell cycle - Caulobacter Molscript image for 1mb3A00 7
3.40.50.2300.27 3crnA00 Response regulator receiver domain protein (CheY-like)Methanospirillum hungatei JF-1 Molscript image for 3crnA00 3
3.40.50.2300.28 3brqB02 Specific transcriptional repressor activitySequence-specific DNA binding transcription factor activityTranscriptionHTH-type transcriptional regulator ascGNegative regulation of gene-specific transcription Molscript image for 3brqB02 5
3.40.50.2300.29 1ys7A01 Transcriptional regulatory protein prrAMycobacterium tuberculosis Molscript image for 1ys7A01 6
3.40.50.2300.30 3c3kA02 Alanine racemaseActinobacillus succinogenes 130ZAlanine racemase. Molscript image for 3c3kA02 2
3.40.50.2300.31 1dz3A00 Geobacillus stearothermophilusStage 0 sporulation protein A Molscript image for 1dz3A00 5
3.40.50.2300.32 3brsA01 Ribose transport system substrate-binding proteinBacterial chemotaxisPeriplasmic binding protein/LacI transcriptional regulatorClostridium phytofermentans ISDgABC transporters Molscript image for 3brsA01 2
3.40.50.2300.33 2h3hB02 Thermotoga maritimaSugar ABC transporter, periplasmic sugar-binding proteinSimple sugar transport system substrate-binding protein Molscript image for 2h3hB02 10
3.40.50.2300.34 3ckmA01 Haemophilus influenzaeUncharacterized protein HI_1655 Molscript image for 3ckmA01 2
3.40.50.2300.35 3cg4A00 Response regulator receiver domain protein (CheY-like)Methanospirillum hungatei JF-1 Molscript image for 3cg4A00 1
3.40.50.2300.36 8abpA02 L-arabinose-binding periplasmic proteinL-arabinose transport system substrate-binding proteinEscherichia coli K-12ABC transporters Molscript image for 8abpA02 12
3.40.50.2300.37 3c3kB01 Alanine racemaseActinobacillus succinogenes 130ZAlanine racemase. Molscript image for 3c3kB01 2
3.40.50.2300.38 3brsA02 Ribose transport system substrate-binding proteinBacterial chemotaxisPeriplasmic binding protein/LacI transcriptional regulatorClostridium phytofermentans ISDgABC transporters Molscript image for 3brsA02 2
3.40.50.2300.39 2jk1A00 Hydrogenase transcriptional regulatory protein hupR1Rhodobacter capsulatus Molscript image for 2jk1A00 3
3.40.50.2300.40 3clkA02 Lactobacillus plantarumTranscription regulator Molscript image for 3clkA02 2
3.40.50.2300.41 2rdmA00 Response regulator receiver proteinSinorhizobium medicae WSM419 Molscript image for 2rdmA00 3
3.40.50.2300.42 2rgyA02 Alanine racemase.Burkholderia phymatum STM815LacI family transcriptional regulatorTranscriptional regulator, LacI family Molscript image for 2rgyA02 27
3.40.50.2300.43 2rjnA00 Response regulator receiver:Metal-dependent phosphohydrolase, HD subdomainNeptuniibacter caesariensis Molscript image for 2rjnA00 1
3.40.50.2300.44 2rjoA01 Burkholderia phytofirmans PsJNPeriplasmic binding protein/LacI transcriptional regulator Molscript image for 2rjoA01 1
3.40.50.2300.45 1r8jB01 Circadian clock protein kaiAIdentical protein bindingCircadian clock protein KaiAEntrainment of circadian clockSynechococcus elongatus PCC 7942 Molscript image for 1r8jB01 4
3.40.50.2300.46 3c3mA00 Response regulator receiver proteinMethanoculleus marisnigri JR1 Molscript image for 3c3mA00 1
3.40.50.2300.47 2qr3A00 Bacteroides fragilisTwo-component system response regulator Molscript image for 2qr3A00 1
3.40.50.2300.48 3gl9B00 Thermotoga maritimaResponse regulatorTwo-component system, unclassified family, response regulatorProtein binding Molscript image for 3gl9B00 4
3.40.50.2300.49 3brqB01 Specific transcriptional repressor activityHTH-type transcriptional regulator ascGTranscriptionSequence-specific DNA binding transcription factor activitySequence-specific DNA binding Molscript image for 3brqB01 5
3.40.50.2300.50 2w42B01 Homologs of the eukaryotic argonaute proteinArchaeoglobus fulgidusPiwi protein AF_1318 Molscript image for 2w42B01 7
3.40.50.2300.51 1zgzA00 TorCAD operon transcriptional regulatory protein torRTwo-component systemTwo-component system, OmpR family, torCAD operon response regulator TorRProtein bindingEscherichia coli K-12 Molscript image for 1zgzA00 8
3.40.50.2300.52 2wjwA02 Alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activityGlutamate receptor 2Synaptic transmissionKainate selective glutamate receptor activityHomo sapiens Molscript image for 2wjwA02 5
3.40.50.2300.53 1dbqA01 LacI family transcriptional regulator, purine nucleotide synthesis repressorHTH-type transcriptional repressor purREscherichia coli K-12 Molscript image for 1dbqA01 26
3.40.50.2300.54 1p2fA01 Thermotoga maritimaResponse regulatorTwo-component system, OmpR family, response regulator Molscript image for 1p2fA01 1
3.40.50.2300.55 2qu7A02 Putative transcriptional regulatorStaphylococcus saprophyticus subsp. saprophyticus ATCC 15305 Molscript image for 2qu7A02 2
3.40.50.2300.56 1srrC00 Sporulation initiation phosphotransferase FBacillus subtilisTwo-component system, response regulator, stage 0 sporulation protein FTransferring phosphorous-containing groups.Two-component system Molscript image for 1srrC00 18
3.40.50.2300.57 3cnbA00 DNA-binding response regulator, merR familyColwellia psychrerythraea 34H Molscript image for 3cnbA00 3
3.40.50.2300.58 2zayA00 Response regulator receiver proteinDesulfuromonas acetoxidans DSM 684 Molscript image for 2zayA00 2
3.40.50.2300.59 3bblA02 Chloroflexus aggregans DSM 9485Alanine racemase.LacI family transcriptional regulator, repressor for deo operon, udp, cdd, tsx, nupC, and nupGTranscriptional regulator, LacI family Molscript image for 3bblA02 1
3.40.50.2300.60 3bblA01 Chloroflexus aggregans DSM 9485Alanine racemase.LacI family transcriptional regulator, repressor for deo operon, udp, cdd, tsx, nupC, and nupGTranscriptional regulator, LacI family Molscript image for 3bblA01 1
3.40.50.2300.61 3cs3A02 Sugar-binding transcriptional regulator, LacI familyLacI family transcriptional regulatorEnterococcus faecalis Molscript image for 3cs3A02 1
3.40.50.2300.62 2fepA02 Bacillus subtilisCatabolite control protein ALacI family transcriptional regulator Molscript image for 2fepA02 28
3.40.50.2300.63 2qxyA00 Thermotoga maritimaResponse regulatorTwo-component system, unclassified family, response regulator Molscript image for 2qxyA00 2
3.40.50.2300.64 2rgyA01 Alanine racemase.Burkholderia phymatum STM815LacI family transcriptional regulatorTranscriptional regulator, LacI family Molscript image for 2rgyA01 1
3.40.50.2300.65 3cg0A00 Desulfovibrio desulfuricans subsp. desulfuricans str. G20Response regulator receiver modulated diguanylate cyclase with PAS/PAC sensor Molscript image for 3cg0A00 4
3.40.50.2300.66 1jx6A01 Vibrio cholerae pathogenic cycleVibrio harveyiAutoinducer 2-binding periplasmic protein LuxPProtein bindingAutoinducer 2-binding periplasmic protein luxP Molscript image for 1jx6A01 4
3.40.50.2300.67 3gt7A00 Sensor proteinHistidine kinase.Syntrophus aciditrophicus SB Molscript image for 3gt7A00 2
3.40.50.2300.68 1ny5A01 Transcriptional regulator (NtrC family)Aquifex aeolicusTwo-component system, NtrC family, response regulator Molscript image for 1ny5A01 9
3.40.50.2300.69 2q5cA01 Clostridium acetobutylicumNtrC family transcriptional regulator (PAS and AAA domains) Molscript image for 2q5cA01 2
3.40.50.2300.70 3b2nA00 Similar to two-component response regulatorStaphylococcus aureus subsp. aureus Mu50 Molscript image for 3b2nA00 1
3.40.50.2300.71 2qsjB00 DNA-binding response regulator, LuxR familyRuegeria pomeroyi Molscript image for 2qsjB00 2
3.40.50.2300.72 1bykA01 Specific transcriptional repressor activitySequence-specific DNA binding transcription factor activityLacI family transcriptional regulator, trehalose operon repressorTranscriptionProtein binding Molscript image for 1bykA01 2
3.40.50.2300.73 1qo0D01 Pseudomonas aeruginosaAliphatic amidase regulator Molscript image for 1qo0D01 2
3.40.50.2300.74 2qu7A01 Putative transcriptional regulatorStaphylococcus saprophyticus subsp. saprophyticus ATCC 15305 Molscript image for 2qu7A01 2
3.40.50.2300.75 1a2oA01 Bacterial chemotaxisChemotaxis response regulator protein-glutamate methylesteraseTwo-component systemSalmonella enterica subsp. enterica serovar TyphimuriumTwo-component system, chemotaxis family, response regulator CheB [EC:3.1.1.61] Molscript image for 1a2oA01 2
3.40.50.2300.76 3bilA02 Corynebacterium glutamicumPROBABLE LACI-FAMILY TRANSCRIPTIONAL REGULATOR Molscript image for 3bilA02 2
3.40.50.2300.77 2r4qA00 PTS system, fructose-specific IIB component [EC:2.7.1.69]PTS system fructose-specific EIIABC componentBacillus subtilisPhosphotransferases with an alcohol group as acceptor.PTS system, fructose-specific IIA component [EC:2.7.1.69] Molscript image for 2r4qA00 2
3.40.50.2300.78 3clkB01 Lactobacillus plantarumTranscription regulator Molscript image for 3clkB01 2
3.40.50.2300.79 1a04A01 Two-component system, NarL family, nitrate/nitrite response regulator NarLTwo-component systemProtein bindingEscherichia coli K-12Nitrate/nitrite response regulator protein narL Molscript image for 1a04A01 3
3.40.50.2300.80 2fepA01 Bacillus subtilisCatabolite control protein ALacI family transcriptional regulator Molscript image for 2fepA01 28
3.40.50.2300.81 2iksB02 LacI family transcriptional regulator, fructose operon transcriptional repressorFructose repressorEscherichia coli K-12 Molscript image for 2iksB02 2
3.40.50.2300.82 1dcfA00 Response to insectResponse to abscisic acid stimulusResponse to heatDefense response to bacteriumResponse to gibberellin stimulus Molscript image for 1dcfA00 1
3.40.50.2300.83 3cs3A01 Sugar-binding transcriptional regulator, LacI familyLacI family transcriptional regulatorEnterococcus faecalis Molscript image for 3cs3A01 1
3.40.50.2300.84 3cz5B00 Two-component response regulator, LuxR familyAurantimonas manganoxydans SI85-9A1 Molscript image for 3cz5B00 4
3.40.50.2300.85 2rjoA02 Burkholderia phytofirmans PsJNPeriplasmic binding protein/LacI transcriptional regulator Molscript image for 2rjoA02 1
3.40.50.2300.86 1w25B02 Identical protein bindingCaulobacter vibrioidesTwo-component systemTwo-component system, cell cycle response regulatorCell cycle - Caulobacter Molscript image for 1w25B02 2
3.40.50.2300.87 2qv0A00 Protein mrkEKlebsiella pneumoniae Molscript image for 2qv0A00 2
3.40.50.2300.88 3cu5B00 Clostridium phytofermentans ISDgTwo component transcriptional regulator, AraC family Molscript image for 3cu5B00 2
3.40.50.2300.89 2hqbA02 Transcriptional activator of comK geneTranscriptional activator of comK geneBacillus halodurans Molscript image for 2hqbA02 1
3.40.50.2300.90 1jdpA01 Natriuretic peptide receptor activityHomo sapiensAtrial natriuretic peptide receptor 3 Molscript image for 1jdpA01 7
3.40.50.2300.91 2iksA01 LacI family transcriptional regulator, fructose operon transcriptional repressorFructose repressorEscherichia coli K-12 Molscript image for 2iksA01 2
3.40.50.2300.92 2hqbA01 Transcriptional activator of comK geneTranscriptional activator of comK geneBacillus halodurans Molscript image for 2hqbA01 1
3.40.50.2300.93 1peaA02 Aliphatic amidase expression-regulating proteinPseudomonas aeruginosaBranched-chain amino acid transport system substrate-binding proteinABC transporters Molscript image for 1peaA02 4
3.40.50.2300.94 1ewkB02 Rattus norvegicusMembrane depolarizationElevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messengerActivation of phospholipase C activity by metabotropic glutamate receptor signaling pathwayPostsynaptic density Molscript image for 1ewkB02 9
3.40.50.2300.95 3d8uA02 Putative transcriptional regulatorVibrio parahaemolyticusLacI family transcriptional regulator, gluconate utilization system Gnt-I transcriptional repressor Molscript image for 3d8uA02 2
3.40.50.2300.96 1usgA01 Leucine-specific-binding proteinBranched-chain amino acid transport system substrate-binding proteinEscherichia coli K-12ABC transporters Molscript image for 1usgA01 13
3.40.50.2300.97 3bilA01 Corynebacterium glutamicumPROBABLE LACI-FAMILY TRANSCRIPTIONAL REGULATOR Molscript image for 3bilA01 2
3.40.50.2300.98 2b4aA00 BH3024 proteinBacillus halodurans Molscript image for 2b4aA00 1
3.40.50.2300.99 1bykA02 Specific transcriptional repressor activityLacI family transcriptional regulator, trehalose operon repressorTranscriptionSequence-specific DNA binding transcription factor activityProtein binding Molscript image for 1bykA02 2
3.40.50.2300.100 2pjuC01 Positive regulation of gene-specific transcriptionPropionate catabolism operon regulatory proteinNegative regulation of gene-specific transcriptionEscherichia coli K-12Specific transcriptional repressor activity Molscript image for 2pjuC01 4
3.40.50.2300.101 1peaA01 Aliphatic amidase expression-regulating proteinPseudomonas aeruginosaBranched-chain amino acid transport system substrate-binding proteinABC transporters Molscript image for 1peaA01 4
3.40.50.2300.102 2wjwA01 Glutamate receptor 2Alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activitySynaptic transmissionKainate selective glutamate receptor activityHomo sapiens Molscript image for 2wjwA01 4
3.40.50.2300.103 3d8uB01 Putative transcriptional regulatorVibrio parahaemolyticusLacI family transcriptional regulator, gluconate utilization system Gnt-I transcriptional repressor Molscript image for 3d8uB01 2
3.40.50.2300.104 2qzjA00 Two-component response regulatorClostridium difficile 630 Molscript image for 2qzjA00 6
3.40.50.2300.105 1dp4C02 Atrial natriuretic peptide receptor 1Rattus norvegicusPurine metabolismGuanylate cyclase.Dopamine metabolic process Molscript image for 1dp4C02 6
3.40.50.2300.106 1jdpB02 Natriuretic peptide receptor activityHomo sapiensAtrial natriuretic peptide receptor 3 Molscript image for 1jdpB02 13
3.40.50.2300.107 3kg2B01 Glutamate receptor 2Rattus norvegicusSynaptic transmissionPerikaryonDendrite cytoplasm Molscript image for 3kg2B01 1
3.40.50.2300.108 3eq2B01 Pseudomonas aeruginosaProbable two-component response regulator Molscript image for 3eq2B01 2
3.40.50.2300.109 1ewkA01 Rattus norvegicusPresynaptic membraneMembrane depolarizationIntegral to plasma membraneElevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger Molscript image for 1ewkA01 9
3.40.50.2300.110 2ayzA00 Two-component systemTwo-component system, NarL family, capsular synthesis sensor histidine kinase RcsC [EC:2.7.13.3]Histidine kinase.Sensor kinase protein rcsCEscherichia coli K-12 Molscript image for 2ayzA00 2
3.40.50.2300.111 1p6qA00 CheY2Two-component system, chemotaxis family, response regulator CheYBacterial chemotaxisSinorhizobium melilotiTwo-component system Molscript image for 1p6qA00 2
3.40.50.2300.112 2kyrA00 Protein-N(pi)-phosphohistidine--sugar phosphotransferase.PTS system, fructose-specific IIB-like component [EC:2.7.1.69]Escherichia coli K-12Fructose-like phosphotransferase enzyme IIB component 1 Molscript image for 2kyrA00 1

Close Structural Clusters 3.40.50.2300 (< 5Å)

Summary of "distant" structural clusters found within this level of CATH.
Cluster ID Example Domain Domains in Cluster Structural Alignment (Core) Structural Alignment (Expanded)
00003.00040.00050.02300/SSG5/1 2qvgA00 10
00003.00040.00050.02300/SSG5/2 1usgA02 4
00003.00040.00050.02300/SSG5/3 3kg2B01 5
00003.00040.00050.02300/SSG5/4 2h3hB02 5
00003.00040.00050.02300/SSG5/5 3clkA02 12
00003.00040.00050.02300/SSG5/6 1s8nA01 2
00003.00040.00050.02300/SSG5/7 1qo0D01 5
00003.00040.00050.02300/SSG5/8 8abpA02 3
00003.00040.00050.02300/SSG5/9 2kyrA00 2
00003.00040.00050.02300/SSG5/10 3brsA01 17
00003.00040.00050.02300/SSG5/11 2hqbA02 4
00003.00040.00050.02300/SSG5/12 2iksA01 7
00003.00040.00050.02300/SSG5/13 1jbeA00 24
00003.00040.00050.02300/SSG5/14 1r8jB01 2
00003.00040.00050.02300/SSG5/15 1jdpA01 2


Distant Structural Clusters 3.40.50.2300 (< 9Å)

Summary of "distant" structural clusters found within this level of CATH.
Cluster ID Example Domain Domains in Cluster Structural Alignment (Core) Structural Alignment (Expanded)
00003.00040.00050.02300/SSGA9/1 1bykA02 6
00003.00040.00050.02300/SSGA9/2 1ys7A01 7
00003.00040.00050.02300/SSGA9/3 2r47A01 3
00003.00040.00050.02300/SSGA9/4 3ckmA01 3
00003.00040.00050.02300/SSGA9/5 3c3kB01 3


Structural Comparisons for Non-redundant S35 Representatives of 3.40.50.2300 ( entries)