CATH Classification

Domain Context

CATH Clusters

Superfamily Aldolase class I
Functional Family Pyridoxine 5'-phosphate synthase

Enzyme Information

2.6.99.2
Pyridoxine 5'-phosphate synthase.
based on mapping to UniProt P0A794
1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate = pyridoxine 5'-phosphate + phosphate + 2 H(2)O.
-!- In Escherichia coli, the coenzyme pyridoxal 5'-phosphate is synthesized de novo by a pathway that involves EC 1.2.1.72, EC 1.1.1.290, EC 2.6.1.52, EC 1.1.1.262, EC 2.6.99.2 and EC 1.4.3.5. -!- 1-deoxy-D-xylulose cannot replace 1-deoxy-D-xylulose 5-phosphate as a substrate.

UniProtKB Entries (1)

P0A794
PDXJ_ECOLI
Escherichia coli K-12
Pyridoxine 5'-phosphate synthase

PDB Structure

PDB 1IXO
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Enzyme-ligand complexes of pyridoxine 5'-phosphate synthase: implications for substrate binding and catalysis
Garrido-Franco, M., Laber, B., Huber, R., Clausen, T.
J.MOL.BIOL.