CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.20 | Alpha-Beta Barrel | |
3.20.20 | TIM Barrel | |
3.20.20.70 | Aldolase class I |
Domain Context
CATH Clusters
Superfamily | Aldolase class I |
Functional Family | Pyridoxine 5'-phosphate synthase |
Enzyme Information
2.6.99.2 |
Pyridoxine 5'-phosphate synthase.
based on mapping to UniProt P0A794
1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate = pyridoxine 5'-phosphate + phosphate + 2 H(2)O.
-!- In Escherichia coli, the coenzyme pyridoxal 5'-phosphate is synthesized de novo by a pathway that involves EC 1.2.1.72, EC 1.1.1.290, EC 2.6.1.52, EC 1.1.1.262, EC 2.6.99.2 and EC 1.4.3.5. -!- 1-deoxy-D-xylulose cannot replace 1-deoxy-D-xylulose 5-phosphate as a substrate.
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UniProtKB Entries (1)
P0A794 |
PDXJ_ECOLI
Escherichia coli K-12
Pyridoxine 5'-phosphate synthase
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PDB Structure
PDB | 1IXO |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Enzyme-ligand complexes of pyridoxine 5'-phosphate synthase: implications for substrate binding and catalysis
J.MOL.BIOL.
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