The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:
"Low-density Lipoprotein Receptor
".
FunFam 12091: Low-density lipoprotein receptor-related protein
There are 7 EC terms in this cluster
Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
EC Term | Annotations | Evidence |
---|---|---|
Complement factor I.
[EC: 3.4.21.45]
Inactivates complement subcomponents C3b, iC3b and C4b by proteolytic cleavage.
|
13 |
B7P761
B7P761
B7PDK0
B7PJ49
B7PJ49
B7PJ49
B7PJ49
B7PJ49
B7Q812
B7QBX8 (3 more...) |
Matriptase.
[EC: 3.4.21.109]
Cleaves various synthetic substrates with Arg or Lys at the P1 position and prefers small side-chain amino acids, such as Ala and Gly, at the P2 position.
|
12 |
A0A1A7YRI5
A0A1A8B8M8
F7CC11
G3PIA1
H0XDT6
H3BG09
H3DFT8
J3SDD6
Q6GR54
Q9DGR1 (2 more...) |
Receptor protein-tyrosine kinase.
[EC: 2.7.10.1]
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
|
9 | A0A0P5CPS6 A0A0P5CPS6 B7PJ49 B7PJ49 B7PJ49 B7PJ49 B7PJ49 B7QBX8 B7QMR1 |
Procollagen C-endopeptidase.
[EC: 3.4.24.19]
Cleavage of the C-terminal propeptide at Ala-|-Asp in type I and II procollagens and at Arg-|-Asp in type III.
|
5 | B7PJ49 B7PJ49 B7PJ49 B7PJ49 B7PJ49 |
Enteropeptidase.
[EC: 3.4.21.9]
Activation of trypsinogen by selective cleavage of 6-Lys-|-Ile-7 bond.
|
5 | B7P761 B7P761 B7QBX8 B7QEG4 E0VZI8 |
Protein C (activated).
[EC: 3.4.21.69]
Degradation of blood coagulation factors Va and VIIIa.
|
1 | B7QMR1 |
Coagulation factor Xa.
[EC: 3.4.21.6]
Selective cleavage of Arg-|-Thr and then Arg-|-Ile bonds in prothrombin to form thrombin.
|
1 | B7QKE3 |