View in Gene3D

CATH Superfamily 4.10.400.10

Low-density Lipoprotein Receptor

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Low-density Lipoprotein Receptor
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
12255
Low-density lipoprotein receptor 2
14524
EC
3D
 2m7pA00 - 91.9
12091
Low-density lipoprotein receptor-related protein
7505
EC
 - - 92.4
12149
Low-density lipoprotein receptor 2
4277
EC
3D
 1f5yA02 - 98.4
12090
Low-density lipoprotein receptor-related protein
3877
EC
 - - 98.5
12263
Very low-density lipoprotein receptor
3185
EC
 - - 97.3
12107
Low-density lipoprotein receptor-related protein
2917
EC
3D
 1j8eA00 - 97.8
12324
Low-density lipoprotein receptor-related protein
2716
EC
 - - 92.7
12137
Low-density lipoprotein receptor 1
2591
EC
 - - 97.8
12097
Low-density lipoprotein receptor-related protein
1730
EC
3D
 1cr8A00 - 85.2
12096
Low-density lipoprotein receptor-related protein-2
1559
EC
 - - 94.6
12116
Low-density lipoprotein receptor
Ldl
1455
EC
 - - 95.2
12290
Low-density lipoprotein receptor-related protein 1
1031
EC
3D
 2fyjA00 - 89.4
12054
Low-density lipoprotein receptor-related protein
905 - - 88.8
12108
Very low-density lipoprotein receptor
872
3D
 2fcwB01 - 87.9
12121
Glucosidase 2 subunit beta
858
EC
 - - 91.0
12067
Very low-density lipoprotein receptor
830
3D
 1n7dA03 - 95.7
12085
Low-density lipoprotein receptor-related protein
821
EC
 - - 84.7
12253
Low-density lipoprotein receptor-related protein 1B
776
3D
 2m96A00 - 94.4
12044
Low-density lipoprotein receptor-related protein-2
713
EC
 - - 97.1
12053
Low-density lipoprotein receptor-related protein-2
633
EC
 - - 89.4
12179
Glucosidase 2 subunit beta
515
EC
 - - 89.8
12169
Low-density lipoprotein receptor-related protein-2
460 - - 87.1
12311
Transmembrane cell adhesion receptor mua-3
449
EC
3D
 1jrfA00 - 95.3
12030
Very low-density lipoprotein receptor
448 - - 81.9
11974
Low-density lipoprotein receptor-related protein 1B
446 - - 73.9
12051
Low-density lipoprotein receptor-related protein
428
EC
 - - 87.1
11961
Low-density lipoprotein receptor-related protein 1
423 - - 83.1
12061
Low-density lipoprotein receptor-related protein 8
409
3D
 1d2jA00 - 82.8
12062
Putative low-density lipoprotein receptor
403
3D
 2i1pA00 - 90.5
11944
Low-density lipoprotein receptor-related protein 1B
386
3D
 2knyA00 - 61.9
12277
Low-density lipoprotein receptor-related protein 12
378 - - 89.3
11898
Low-density lipoprotein receptor-related protein 1B
357 - - 85.1
12267
Atrial natriuretic peptide-converting enzyme
335 - - 74.0
12261
Atrial natriuretic peptide-converting enzyme
330 - - 86.2
12268
Low-density lipoprotein receptor-related protein
314 - - 98.5
12319
Low-density lipoprotein receptor-related protein
283
EC
 - - 97.3
11976
Putative low-density lipoprotein receptor
269 - - 81.8
12023
Low-density lipoprotein receptor-related protein 3
264 - - 81.4
12064
Low-density lipoprotein receptor-related protein 2
263
EC
 - - 93.2
12015
Low-density lipoprotein receptor-related protein 1B
248 - - 77.0
12321
Terribly reduced optic lobes, isoform AQ
247 - - 94.0
12280
Sortilin-related receptor, L
DLR class
216 - - 89.0
11942
Complement component C8 alpha chain
206 - - 86.5
640
Prolow-density lipoprotein receptor-related protein 1
199 - - 61.7
11564
Prolow-density lipoprotein receptor-related protein 1
189
3D
 1d2lA00 - 54.7
395
Prolow-density lipoprotein receptor-related protein 1
183 - - 39.2
12354
Transmembrane cell adhesion receptor mua-3
182 - - 97.2
11910
Low-density lipoprotein receptor-related protein
172 - - 66.3
12003
Sortilin-related receptor, L
DLR class
169 - - 82.8
11610
Prolow-density lipoprotein receptor-related protein 1
167 - - 62.2
11955
Prolow-density lipoprotein receptor-related protein 1
165 - - 80.8
12024
Low-density lipoprotein receptor 2
165
3D
 1f5yA01 - 82.1
12109
Low-density lipoprotein receptor-related protein 2
157 - - 77.9
11598
Neuropilin and tolloid-like protein 2
157 - - 66.6
11980
Low-density lipoprotein receptor-related protein 12
157 - - 28.7
12039
Low-density lipoprotein receptor-related protein
147
EC
 - - 79.4
12020
Sortilin-related receptor, L A repeats-containing
147 - - 91.0
12027
Very low-density lipoprotein receptor
144
3D
 1n7dA06 - 71.0
5752
Terribly reduced optic lobes, isoform AH
140 - - 34.4
11633
Sortilin-related receptor
140 - - 75.9
11853
Low-density lipoprotein receptor
Ldl
138
EC
 - - 72.1
11595
Sortilin-related receptor, L A repeats-containing
137 - - 61.4
12306
Terribly reduced optic lobes, isoform AP
136 - - 84.9
11619
Low-density lipoprotein receptor-related protein 2
136 - - 49.7
11661
Sortilin-related receptor, L
DLR class
135 - - 58.8
11950
Low-density lipoprotein receptor class A domain-containing protein 3
135 - - 49.0
11930
Prolow-density lipoprotein receptor-related protein 1
131 - - 80.4
12117
Basement membrane-specific heparan sulfate proteoglycan core protein
129 - - 82.4
9470
Transmembrane protease serine 6
119 - - 42.0
11912
Low-density lipoprotein receptor-related protein 2
119 - - 71.8
11757
Low-density lipoprotein receptor-related protein 6
119 - - 76.5
3872
Low-density lipoprotein receptor-related protein 4
118 - - 50.0
11953
Low-density lipoprotein receptor-related protein 5
116 - - 64.4
11604
Relaxin receptor 1
115
3D
 2jm4A00 - 58.0
11584
Low-density lipoprotein receptor-related protein 1B
115 - - 64.8
273
Atrial natriuretic peptide-converting enzyme
104 - - 37.7
12271
MAM and LDL-receptor class A domain-containing protein
104 - - 92.1
12230
Membrane frizzled-related protein
103 - - 87.4
11663
Low-density lipoprotein receptor-related protein 1B
102 - - 49.1
11659
Atrial natriuretic peptide-converting enzyme
101 - - 45.5
11917
Low-density lipoprotein receptor 2
95
3D
 1n7dA04 - 63.2
11734
Low-density lipoprotein receptor-related protein 1B
94 - - 60.5
11941
Prolow-density lipoprotein receptor-related protein 1
93 - - 49.5
12087
G-protein coupled receptor GRL101
92
EC
 - - 81.9
11947
CD320 antigen isoform 002
90 - - 65.8
11664
Zinc finger protein 862
90 - - 61.0
12198
Sortilin-related receptor, L
DLR class
87 - - 75.5
11597
Very low-density lipoprotein receptor
86 - - 46.3
11683
Atrial natriuretic peptide-converting enzyme
84 - - 21.8
12007
Transmembrane protease serine 6
80 - - 64.2
12286
ALK tyrosine kinase receptor
80
EC
 - - 96.1
2122
Very low-density lipoprotein receptor
80 - - 46.1
11651
Atrial natriuretic peptide-converting enzyme
74 - - 41.7
4964
Low-density lipoprotein receptor
Ldl
73 - - 46.6
11704
Low-density lipoprotein receptor-related protein 11
72 - - 56.7
6873
Low-density lipoprotein receptor-related protein 6
72 - - 43.5
940
Low-density lipoprotein receptor-related protein 4
71 - - 35.6
1508
Low-density lipoprotein receptor-related protein 3
71 - - 36.2
4137
Uncharacterized protein
70 - - 26.2
1682
Low-density lipoprotein receptor-related protein 1B
69 - - 36.1
11724
Transmembrane protease serine 7
64 - - 72.4
11972
Low-density lipoprotein receptor-related protein 2
63 - - 54.1
2487
Low-density lipoprotein receptor
Ldl
61 - - 25.9
11890
Enteropeptidase
59
EC
 - - 61.8
4431
Low-density lipoprotein receptor-related protein 4
59 - - 27.4
11726
Low-density lipoprotein receptor-related protein 1B
53 - - 36.6
11902
Suppressor of tumorigenicity 14 protein
52
EC
 - - 55.8
6883
Basement membrane-specific heparan sulfate proteoglycan core protein
51 - - 15.7
11750
Transmembrane protease serine 6
50 - - 33.8
11778
Prolow-density lipoprotein receptor-related protein 1
49 - - 30.1
1958
Low-density lipoprotein receptor-related protein 2
49 - - 50.2
1960
Low-density lipoprotein receptor-related protein 2
48 - - 35.3
997
Low-density lipoprotein receptor-related protein
48 - - 55.5
8780
Low-density lipoprotein receptor-related protein 1B
48 - - 34.7
719
Lipophorin receptor 1, isoform G
48 - - 20.9
11685
Low-density lipoprotein receptor-related protein 8
47 - - 48.0
3472
Low-density lipoprotein receptor-related protein
44 - - 43.0
11745
Transmembrane protease serine 9
42 - - 53.7
12273
RME-2, isoform b
39 - - 79.3
11791
Low-density lipoprotein receptor-related protein 8
39 - - 44.3
491
Low-density lipoprotein receptor-related protein 2
39 - - 29.4
5482
Terribly reduced optic lobes, isoform AN
39 - - 17.4
3232
Low-density lipoprotein receptor class A domain-containing protein 1
39 - - 46.4
4435
Low-density lipoprotein receptor-related protein 2
37 - - 36.0
11671
Low-density lipoprotein receptor-related protein 12
33 - - 29.3
11702
Low-density lipoprotein receptor-related protein 2
32 - - 43.7
11908
SCO-spondin
30 - - 50.7
12225
Putative vitellogenin receptor
28 - - 82.9
8003
Ecdysone-inducible gene E1, isoform A
28 - - 8.8
5693
Ecdysone-inducible gene E1, isoform A
28 - - 13.5
11918
SCO-spondin
27 - - 42.2
7025
Transmembrane protease serine 13
26 - - 41.0
255
Low-density lipoprotein receptor-related protein
26 - - 39.4
1961
Terribly reduced optic lobes, isoform AK
25 - - 9.0
6891
Megalin, isoform A
23 - - 30.8
365
Terribly reduced optic lobes, isoform AX
23 - - 12.0
10198
Low-density lipoprotein receptor-related protein 5
23 - - 44.4
11713
Kunitz-type protease inhibitor 1
23 - - 37.8
2753
Suppressor of tumorigenicity protein 14
21
EC
 - - 38.0
6875
Low-density lipoprotein receptor class A domain-containing protein 1
20 - - 45.2
8743
LDL receptor-like repeat
20 - - 54.8
4885
Low-density lipoprotein receptor-related protein 2
20 - - 22.2
11923
Low-density lipoprotein receptor-related protein 2
20 - - 38.9
1411
Low-density lipoprotein receptor-related protein 2
19 - - 22.4
3473
Low-density lipoprotein receptor-related protein
18 - - 27.8
6541
LDL-related protein LRP6
17 - - 33.0
3479
DIET1
17 - - 26.9
3477
Low-density lipoprotein receptor-related protein 2
17 - - 27.6
4459
Low-density lipoprotein receptor-related protein 2
17
3D
 2m0pA00 - 27.7
9469
Transmembrane protease serine 4
15 - - 10.9
12320
Putative vitellogenin receptor
15 - - 84.2
6936
Corin, isoform B
14 - - 10.3
1018
Megalin, isoform A
13 - - 15.9
4263
Glycoprotein receptor gp330/megalin
13 - - 19.8
5659
DIET1
11 - - 3.1
9685
Terribly reduced optic lobes, isoform AF
11 - - 19.2
1964
LDL receptor-like repeat
11 - - 0.0
6152
Ecdysone-inducible gene E1, isoform A
11 - - 5.5
714
Terribly reduced optic lobes, isoform AK
11 - - 7.6
3480
cDNA FLJ60310
11 - - 12.5
3478
Low-density lipoprotein receptor-related protein 2
11 - - 12.9
1567
Lipophorin receptor 2, isoform A
9 - - 15.5
11311
Low-density lipoprotein receptor-related protein 2
9 - - 5.9
1934
Putative vitellogenin receptor
9 - - 13.1
10162
Low-density lipoprotein receptor-related protein 2
8 - - 9.7
3819
Apical endosomal glycoprotein
8 - - 8.5
10176
LDL receptor-like repeat
7 - - 18.1
3494
LDL receptor-like repeat
7 - - 5.7
5086
Lipophorin receptor 2, isoform A
7 - - 11.1
1404
DIET1
7 - - 27.9
1234
Uncharacterized protein F44E2.4
7 - - 40.4
6043
RT10567p
6 - - 13.5
7894
Membrane frizzled-related protein
6 - - 4.8
2641
Low density lipoprotein receptor
6 - - 17.8
4434
Transmembrane protease serine 2
6 - - 21.4
2446
Low-density lipoprotein receptor-related protein
6 - - 10.1
6970
Low-density lipoprotein receptor-related protein
6 - - 21.8
881
Low-density lipoprotein receptor-related protein
6 - - 7.3
7912
DIET1
6 - - 6.9
5654
Low-density lipoprotein receptor-related protein
6 - - 7.5
5639
Membrane bound arginine specific serine protease
6
EC
 - - 14.4
11590
Apical endosomal glycoprotein
6 - - 33.6
5855
EG:BACR25B3.1 protein
5 - - 3.9
8863
EG:BACR25B3.1 protein
5 - - 6.5
268
LEV-10, isoform b
5 - - 20.4
2255
Putative vitellogenin receptor
5 - - 17.4
1403
Low-density lipoprotein receptor-related protein
5 - - 24.3
2989
Uninflatable, isoform C
4 - - 17.4
7895
Serine protease nudel
4 - - 10.9
4199
Serine protease nudel
4 - - 23.1
4527
Lipophorin receptor 2, isoform G
4 - - 0.0
3555
Lipophorin receptor 2, isoform B
4 - - 0.0
6871
Low-density lipoprotein receptor-related protein 8
3 - - 0.0
4456
Low-density lipoprotein receptor-related protein
3 - - 26.6
9928
Transmembrane protease serine 4
3 - - 10.9
9502
Suppressor of tumorigenicity 14 protein homolog
3
EC
 - - 0.0
3502
Suppressor of tumorigenicity 14 protein homolog
3
EC
 - - 0.0
8112
Low-density lipoprotein receptor 1
3 - - 2.9
8406
Serine protease nudel
3 - - 10.9
12187
Yolk receptor RME-2
2 - - 49.8
11562
Low-density lipoprotein receptor-related protein 2
2 - - 0.0
7891
Low-density lipoprotein receptor-related protein 10
2 - - 0.0
6134
EG:BACR25B3.1 protein
2 - - 0.0
5631
Low-density lipoprotein receptor-related protein 2
2 - - 0.0
11658
EGG-2
2 - - 32.1
684
Megalin, isoform A
2 - - 0.0
11883
SCO-spondin
2 - - 52.0
7901
Transmembrane protease serine 2
2 - - 3.3
3453
Low-density lipoprotein receptor-related protein 2
2 - - 0.0
3461
Suppressor of tumorigenicity 14 protein homolog
2
EC
 - - 0.0
5650
G-protein coupled receptor GRL101
1 - - 0.0
11759
EGG-1
1 - - 0.0
673
G-protein coupled receptor GRL101
1 - - 0.0
10744
G-protein coupled receptor GRL101
1 - - 0.0
956
GL15420
1 - - 0.0
964
LRP-2
1 - - 0.0
3604
Serine protease inhibitor, Kunitz type 1 b
1 - - 0.0
8728
SCO-spondin
1 - - 0.0
115
Megalin, isoform A
1 - - 0.0
1775
Low-density lipoprotein receptor-related protein
1 - - 0.0
10779
Low-density lipoprotein receptor-related protein 2
1 - - 0.0
11609
EGG-1
1 - - 0.0