The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:
"Cysteine proteinases
".
FunFam 17149: Calpain 2, (M/II) large subunit
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 39 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
|
25 |
B5AFM5 (/ISS)
E2R8T7 (/ISS)
F6RX57 (/ISS)
F6TMZ0 (/ISS)
G1KRC7 (/ISS)
G1MBZ6 (/ISS)
G1QWI5 (/ISS)
G1TSG0 (/ISS)
G3H0X3 (/ISS)
G3TVX4 (/ISS)
(15 more) |
Catalytic activity GO:0003824
Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
|
21 |
B5AFM5 (/ISS)
E2R8T7 (/ISS)
F6RX57 (/ISS)
F6TMZ0 (/ISS)
G1KRC7 (/ISS)
G1MBZ6 (/ISS)
G1QWI5 (/ISS)
G1TSG0 (/ISS)
G3H0X3 (/ISS)
G3TVX4 (/ISS)
(11 more) |
Structural constituent of muscle GO:0008307
The action of a molecule that contributes to the structural integrity of a muscle fiber.
|
21 |
B5AFM5 (/ISS)
E2R8T7 (/ISS)
F6RX57 (/ISS)
F6TMZ0 (/ISS)
G1KRC7 (/ISS)
G1MBZ6 (/ISS)
G1QWI5 (/ISS)
G1TSG0 (/ISS)
G3H0X3 (/ISS)
G3TVX4 (/ISS)
(11 more) |
Sodium ion binding GO:0031402
Interacting selectively and non-covalently with sodium ions (Na+).
|
21 |
B5AFM5 (/ISS)
E2R8T7 (/ISS)
F6RX57 (/ISS)
F6TMZ0 (/ISS)
G1KRC7 (/ISS)
G1MBZ6 (/ISS)
G1QWI5 (/ISS)
G1TSG0 (/ISS)
G3H0X3 (/ISS)
G3TVX4 (/ISS)
(11 more) |
Protein complex scaffold GO:0032947
A structural molecule activity that provides a physical support for the assembly of a multiprotein complex. The scaffold may or may not be part of the final complex.
|
21 |
B5AFM5 (/ISS)
E2R8T7 (/ISS)
F6RX57 (/ISS)
F6TMZ0 (/ISS)
G1KRC7 (/ISS)
G1MBZ6 (/ISS)
G1QWI5 (/ISS)
G1TSG0 (/ISS)
G3H0X3 (/ISS)
G3TVX4 (/ISS)
(11 more) |
Ligase regulator activity GO:0055103
Modulates the activity of a ligase.
|
21 |
B5AFM5 (/ISS)
E2R8T7 (/ISS)
F6RX57 (/ISS)
F6TMZ0 (/ISS)
G1KRC7 (/ISS)
G1MBZ6 (/ISS)
G1QWI5 (/ISS)
G1TSG0 (/ISS)
G3H0X3 (/ISS)
G3TVX4 (/ISS)
(11 more) |
Peptidase activity GO:0008233
Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
|
20 |
B5AFM5 (/ISS)
E2R8T7 (/ISS)
F6RX57 (/ISS)
F6TMZ0 (/ISS)
G1KRC7 (/ISS)
G1MBZ6 (/ISS)
G1QWI5 (/ISS)
G1TSG0 (/ISS)
G3H0X3 (/ISS)
G3TVX4 (/ISS)
(10 more) |
Titin binding GO:0031432
Interacting selectively and non-covalently with titin, any of a family of giant proteins found in striated and smooth muscle. In striated muscle, single titin molecules span half the sarcomere, with their N- and C-termini in the Z-disc and M-line, respectively.
|
20 |
B5AFM5 (/ISS)
E2R8T7 (/ISS)
F6RX57 (/ISS)
F6TMZ0 (/ISS)
G1KRC7 (/ISS)
G1MBZ6 (/ISS)
G1QWI5 (/ISS)
G1TSG0 (/ISS)
G3H0X3 (/ISS)
G3TVX4 (/ISS)
(10 more) |
Calcium-dependent cysteine-type endopeptidase activity GO:0004198
Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium.
|
15 |
P07384 (/ISS)
P17655 (/ISS)
P20807 (/ISS)
P35750 (/ISS)
P43368 (/ISS)
P51186 (/ISS)
Q27970 (/ISS)
Q27971 (/ISS)
Q5NVS7 (/ISS)
Q92177 (/ISS)
(5 more) |
Calcium-dependent cysteine-type endopeptidase activity GO:0004198
Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium.
|
11 |
O08529 (/IDA)
O35350 (/IDA)
P07384 (/IDA)
P16259 (/IDA)
P17655 (/IDA)
P35750 (/IDA)
P97571 (/IDA)
Q07009 (/IDA)
Q11002 (/IDA)
Q64691 (/IDA)
(1 more) |
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
9 | O35350 (/IPI) P07384 (/IPI) P16259 (/IPI) P17655 (/IPI) P20807 (/IPI) P97571 (/IPI) Q07009 (/IPI) Q64691 (/IPI) Q9VT65 (/IPI) |
Calcium-dependent cysteine-type endopeptidase activity GO:0004198
Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium.
|
7 | O08529 (/TAS) O14815 (/TAS) O35350 (/TAS) O35920 (/TAS) P16259 (/TAS) P20807 (/TAS) Q9UMQ6 (/TAS) |
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
|
4 | P07384 (/IDA) P97571 (/IDA) Q07009 (/IDA) Q64691 (/IDA) |
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
|
3 | O14815 (/TAS) O35920 (/TAS) P16259 (/TAS) |
Peptidase activity GO:0008233
Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
|
3 | O08529 (/IDA) P16259 (/IDA) P20807 (/IDA) |
Calcium-dependent cysteine-type endopeptidase activity GO:0004198
Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium.
|
2 | O08529 (/ISO) O35350 (/ISO) |
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
|
2 | Q11002 (/NAS) Q9VT65 (/NAS) |
Cytoskeletal protein binding GO:0008092
Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton).
|
2 | P97571 (/IDA) Q07009 (/IDA) |
Cysteine-type peptidase activity GO:0008234
Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
|
2 | P17655 (/TAS) P20807 (/TAS) |
Protein tyrosine kinase binding GO:1990782
Interacting selectively and non-covalently with protein tyrosine kinase.
|
2 | E1BR22 (/IPI) Q92178 (/IPI) |
Catalytic activity GO:0003824
Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
|
1 | P20807 (/IDA) |
Catalytic activity GO:0003824
Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
|
1 | Q64691 (/ISO) |
Endopeptidase activity GO:0004175
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.
|
1 | P07384 (/TAS) |
Signal transducer activity GO:0004871
Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
|
1 | P20807 (/TAS) |
Receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
|
1 | P16259 (/IPI) |
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
|
1 | O35350 (/ISO) |
Cytoskeletal protein binding GO:0008092
Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton).
|
1 | P17655 (/NAS) |
Peptidase activity GO:0008233
Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
|
1 | Q64691 (/ISO) |
Peptidase activity GO:0008233
Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
|
1 | Q9UMQ6 (/TAS) |
Structural constituent of muscle GO:0008307
The action of a molecule that contributes to the structural integrity of a muscle fiber.
|
1 | Q64691 (/IMP) |
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
|
1 | P16259 (/IPI) |
Sodium ion binding GO:0031402
Interacting selectively and non-covalently with sodium ions (Na+).
|
1 | Q64691 (/IDA) |
Titin binding GO:0031432
Interacting selectively and non-covalently with titin, any of a family of giant proteins found in striated and smooth muscle. In striated muscle, single titin molecules span half the sarcomere, with their N- and C-termini in the Z-disc and M-line, respectively.
|
1 | P16259 (/IDA) |
Titin binding GO:0031432
Interacting selectively and non-covalently with titin, any of a family of giant proteins found in striated and smooth muscle. In striated muscle, single titin molecules span half the sarcomere, with their N- and C-termini in the Z-disc and M-line, respectively.
|
1 | P20807 (/IPI) |
Titin binding GO:0031432
Interacting selectively and non-covalently with titin, any of a family of giant proteins found in striated and smooth muscle. In striated muscle, single titin molecules span half the sarcomere, with their N- and C-termini in the Z-disc and M-line, respectively.
|
1 | Q64691 (/ISO) |
Protein complex scaffold GO:0032947
A structural molecule activity that provides a physical support for the assembly of a multiprotein complex. The scaffold may or may not be part of the final complex.
|
1 | Q64691 (/IMP) |
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
|
1 | Q07009 (/IPI) |
Ligase regulator activity GO:0055103
Modulates the activity of a ligase.
|
1 | P20807 (/IDA) |
Ligase regulator activity GO:0055103
Modulates the activity of a ligase.
|
1 | Q64691 (/ISO) |
There are 95 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
|
29 |
B5AFM5 (/ISS)
E2R8T7 (/ISS)
F6RX57 (/ISS)
F6TMZ0 (/ISS)
G1KRC7 (/ISS)
G1MBZ6 (/ISS)
G1QWI5 (/ISS)
G1TSG0 (/ISS)
G3H0X3 (/ISS)
G3TVX4 (/ISS)
(19 more) |
Regulation of catalytic activity GO:0050790
Any process that modulates the activity of an enzyme.
|
26 |
B5AFM5 (/ISS)
E2R8T7 (/ISS)
F6RX57 (/ISS)
F6TMZ0 (/ISS)
G1KRC7 (/ISS)
G1MBZ6 (/ISS)
G1QWI5 (/ISS)
G1TSG0 (/ISS)
G3H0X3 (/ISS)
G3TVX4 (/ISS)
(16 more) |
Self proteolysis GO:0097264
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their own peptide bonds.
|
25 |
B5AFM5 (/ISS)
E2R8T7 (/ISS)
F6RX57 (/ISS)
F6TMZ0 (/ISS)
G1KRC7 (/ISS)
G1MBZ6 (/ISS)
G1QWI5 (/ISS)
G1TSG0 (/ISS)
G3H0X3 (/ISS)
G3TVX4 (/ISS)
(15 more) |
Protein complex assembly GO:0006461
The aggregation, arrangement and bonding together of a set of components to form a protein complex.
|
21 |
B5AFM5 (/ISS)
E2R8T7 (/ISS)
F6RX57 (/ISS)
F6TMZ0 (/ISS)
G1KRC7 (/ISS)
G1MBZ6 (/ISS)
G1QWI5 (/ISS)
G1TSG0 (/ISS)
G3H0X3 (/ISS)
G3TVX4 (/ISS)
(11 more) |
Positive regulation of satellite cell activation involved in skeletal muscle regeneration GO:0014718
Any process that activates, maintains or increases the frequency, rate or extent of activation of satellite cell involved in skeletal muscle regeneration. The activation of satellite cell is the process that initiates satellite cell division by causing it to move from quiescence to the G1 stage of the cell cycle. The cell swells and there are a number of other small changes. The cells then start to divide. Following cell division the cells will differentiate.
|
21 |
B5AFM5 (/ISS)
E2R8T7 (/ISS)
F6RX57 (/ISS)
F6TMZ0 (/ISS)
G1KRC7 (/ISS)
G1MBZ6 (/ISS)
G1QWI5 (/ISS)
G1TSG0 (/ISS)
G3H0X3 (/ISS)
G3TVX4 (/ISS)
(11 more) |
Response to muscle activity GO:0014850
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle activity stimulus.
|
21 |
B5AFM5 (/ISS)
E2R8T7 (/ISS)
F6RX57 (/ISS)
F6TMZ0 (/ISS)
G1KRC7 (/ISS)
G1MBZ6 (/ISS)
G1QWI5 (/ISS)
G1TSG0 (/ISS)
G3H0X3 (/ISS)
G3TVX4 (/ISS)
(11 more) |
Negative regulation of protein sumoylation GO:0033234
Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of SUMO groups to a protein.
|
21 |
B5AFM5 (/ISS)
E2R8T7 (/ISS)
F6RX57 (/ISS)
F6TMZ0 (/ISS)
G1KRC7 (/ISS)
G1MBZ6 (/ISS)
G1QWI5 (/ISS)
G1TSG0 (/ISS)
G3H0X3 (/ISS)
G3TVX4 (/ISS)
(11 more) |
Sarcomere organization GO:0045214
The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
|
21 |
B5AFM5 (/ISS)
E2R8T7 (/ISS)
F6RX57 (/ISS)
F6TMZ0 (/ISS)
G1KRC7 (/ISS)
G1MBZ6 (/ISS)
G1QWI5 (/ISS)
G1TSG0 (/ISS)
G3H0X3 (/ISS)
G3TVX4 (/ISS)
(11 more) |
Positive regulation of proteolysis GO:0045862
Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.
|
21 |
B5AFM5 (/ISS)
E2R8T7 (/ISS)
F6RX57 (/ISS)
F6TMZ0 (/ISS)
G1KRC7 (/ISS)
G1MBZ6 (/ISS)
G1QWI5 (/ISS)
G1TSG0 (/ISS)
G3H0X3 (/ISS)
G3TVX4 (/ISS)
(11 more) |
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
21 |
B5AFM5 (/ISS)
E2R8T7 (/ISS)
F6RX57 (/ISS)
F6TMZ0 (/ISS)
G1KRC7 (/ISS)
G1MBZ6 (/ISS)
G1QWI5 (/ISS)
G1TSG0 (/ISS)
G3H0X3 (/ISS)
G3TVX4 (/ISS)
(11 more) |
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
20 |
B5AFM5 (/ISS)
E2R8T7 (/ISS)
F6RX57 (/ISS)
F6TMZ0 (/ISS)
G1KRC7 (/ISS)
G1MBZ6 (/ISS)
G1QWI5 (/ISS)
G1TSG0 (/ISS)
G3H0X3 (/ISS)
G3TVX4 (/ISS)
(10 more) |
Regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122
Any process that modulates I-kappaB kinase/NF-kappaB signaling.
|
20 |
B5AFM5 (/ISS)
E2R8T7 (/ISS)
F6RX57 (/ISS)
F6TMZ0 (/ISS)
G1KRC7 (/ISS)
G1MBZ6 (/ISS)
G1QWI5 (/ISS)
G1TSG0 (/ISS)
G3H0X3 (/ISS)
G3TVX4 (/ISS)
(10 more) |
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
20 |
B5AFM5 (/ISS)
E2R8T7 (/ISS)
F6RX57 (/ISS)
F6TMZ0 (/ISS)
G1KRC7 (/ISS)
G1MBZ6 (/ISS)
G1QWI5 (/ISS)
G1TSG0 (/ISS)
G3H0X3 (/ISS)
G3TVX4 (/ISS)
(10 more) |
Positive regulation of NF-kappaB transcription factor activity GO:0051092
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
|
20 |
B5AFM5 (/ISS)
E2R8T7 (/ISS)
F6RX57 (/ISS)
F6TMZ0 (/ISS)
G1KRC7 (/ISS)
G1MBZ6 (/ISS)
G1QWI5 (/ISS)
G1TSG0 (/ISS)
G3H0X3 (/ISS)
G3TVX4 (/ISS)
(10 more) |
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
|
10 | O08529 (/IDA) P07384 (/IDA) P16259 (/IDA) P20807 (/IDA) P35750 (/IDA) P97571 (/IDA) Q07009 (/IDA) Q11002 (/IDA) Q64691 (/IDA) Q9VT65 (/IDA) |
Myofibril assembly GO:0030239
Formation of myofibrils, the repeating units of striated muscle.
|
7 | P16259 (/ISS) P20807 (/ISS) P43368 (/ISS) P51186 (/ISS) Q92177 (/ISS) Q9GLG7 (/ISS) Q9TTH8 (/ISS) |
Positive regulation of release of sequestered calcium ion into cytosol GO:0051281
Any process that activates or increases the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria.
|
7 | P16259 (/ISS) P20807 (/ISS) P43368 (/ISS) P51186 (/ISS) Q92177 (/ISS) Q9GLG7 (/ISS) Q9TTH8 (/ISS) |
Response to calcium ion GO:0051592
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
|
7 | P20807 (/ISS) P43368 (/ISS) P51186 (/ISS) Q64691 (/ISS) Q92177 (/ISS) Q9GLG7 (/ISS) Q9TTH8 (/ISS) |
Muscle structure development GO:0061061
The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms.
|
7 | P16259 (/ISS) P20807 (/ISS) P43368 (/ISS) P51186 (/ISS) Q92177 (/ISS) Q9GLG7 (/ISS) Q9TTH8 (/ISS) |
Cellular response to calcium ion GO:0071277
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
|
7 | P16259 (/ISS) P20807 (/ISS) P43368 (/ISS) P51186 (/ISS) Q92177 (/ISS) Q9GLG7 (/ISS) Q9TTH8 (/ISS) |
Cellular response to salt stress GO:0071472
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
|
7 | P16259 (/ISS) P20807 (/ISS) P43368 (/ISS) P51186 (/ISS) Q92177 (/ISS) Q9GLG7 (/ISS) Q9TTH8 (/ISS) |
Protein localization to membrane GO:0072657
A process in which a protein is transported to, or maintained in, a specific location in a membrane.
|
7 | P16259 (/ISS) P20807 (/ISS) P43368 (/ISS) P51186 (/ISS) Q92177 (/ISS) Q9GLG7 (/ISS) Q9TTH8 (/ISS) |
Protein autoprocessing GO:0016540
Processing which a protein carries out itself. This involves actions such as the autolytic removal of residues to generate the mature form of the protein.
|
4 | P97571 (/IDA) Q07009 (/IDA) Q11002 (/IDA) Q9VT65 (/IDA) |
Cellular response to amino acid stimulus GO:0071230
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups.
|
4 | P17655 (/ISS) Q27971 (/ISS) Q92178 (/ISS) Q9GLG1 (/ISS) |
Self proteolysis GO:0097264
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their own peptide bonds.
|
3 | P07384 (/IDA) P16259 (/IDA) P20807 (/IDA) |
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
|
2 | O35350 (/ISO) Q64691 (/ISO) |
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
|
2 | P16259 (/TAS) Q07009 (/TAS) |
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
|
2 | A0A0R4ID08 (/IMP) B8A6G0 (/IMP) |
Myoblast fusion GO:0007520
A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
|
2 | O08529 (/IMP) Q11002 (/IMP) |
Neuron remodeling GO:0016322
The developmentally regulated remodeling of neuronal projections such as pruning to eliminate the extra dendrites and axons projections set up in early stages of nervous system development.
|
2 | Q11002 (/IGI) Q9VT65 (/IGI) |
Neuron remodeling GO:0016322
The developmentally regulated remodeling of neuronal projections such as pruning to eliminate the extra dendrites and axons projections set up in early stages of nervous system development.
|
2 | Q11002 (/IMP) Q9VT65 (/IMP) |
Protein autoprocessing GO:0016540
Processing which a protein carries out itself. This involves actions such as the autolytic removal of residues to generate the mature form of the protein.
|
2 | P97571 (/IC) Q07009 (/IC) |
Protein autoprocessing GO:0016540
Processing which a protein carries out itself. This involves actions such as the autolytic removal of residues to generate the mature form of the protein.
|
2 | Q11002 (/TAS) Q9VT65 (/TAS) |
Branchiomotor neuron axon guidance GO:0021785
The process in which a branchiomotor neuron growth cone is directed to a specific target site. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx.
|
2 | A0A0R4ID08 (/IMP) B8A6G0 (/IMP) |
Extracellular matrix disassembly GO:0022617
A process that results in the breakdown of the extracellular matrix.
|
2 | P07384 (/TAS) P17655 (/TAS) |
Protein catabolic process GO:0030163
The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
|
2 | E9QE31 (/IGI) F1R632 (/IGI) |
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
2 | P20807 (/IMP) Q64691 (/IMP) |
Regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122
Any process that modulates I-kappaB kinase/NF-kappaB signaling.
|
2 | P20807 (/IMP) Q64691 (/IMP) |
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
2 | P20807 (/IMP) Q64691 (/IMP) |
Regulation of catalytic activity GO:0050790
Any process that modulates the activity of an enzyme.
|
2 | P07384 (/IDA) P20807 (/IDA) |
Regulation of catalytic activity GO:0050790
Any process that modulates the activity of an enzyme.
|
2 | O35350 (/ISO) Q64691 (/ISO) |
Positive regulation of NF-kappaB transcription factor activity GO:0051092
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
|
2 | P20807 (/IMP) Q64691 (/IMP) |
Cellular response to amino acid stimulus GO:0071230
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups.
|
2 | O08529 (/IDA) Q07009 (/IDA) |
Self proteolysis GO:0097264
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their own peptide bonds.
|
2 | O35350 (/ISO) Q64691 (/ISO) |
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
|
1 | Q07009 (/IEP) |
Blastocyst development GO:0001824
The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm.
|
1 | O08529 (/IMP) |
Protein complex assembly GO:0006461
The aggregation, arrangement and bonding together of a set of components to form a protein complex.
|
1 | Q64691 (/IMP) |
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
|
1 | O35350 (/IMP) |
Phagocytosis GO:0006909
An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.
|
1 | Q11002 (/IMP) |
Apoptotic process GO:0006915
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
|
1 | P20807 (/TAS) |
Border follicle cell migration GO:0007298
The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster.
|
1 | Q9VT65 (/IMP) |
Muscle organ development GO:0007517
The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.
|
1 | P20807 (/TAS) |
Digestion GO:0007586
The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.
|
1 | O14815 (/TAS) |
Positive regulation of cell proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
|
1 | P07384 (/TAS) |
Determination of adult lifespan GO:0008340
The control of viability and duration in the adult phase of the life-cycle.
|
1 | Q11002 (/IMP) |
Larval locomotory behavior GO:0008345
Locomotory behavior in a larval (immature) organism.
|
1 | Q11002 (/IMP) |
Dorsal/ventral pattern formation GO:0009953
The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism.
|
1 | Q11002 (/IDA) |
Positive regulation of necrotic cell death GO:0010940
Any process that increases the rate, frequency or extent of necrotic cell death. Necrotic cell death is a cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents.
|
1 | P34308 (/IGI) |
Programmed cell death GO:0012501
A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell.
|
1 | Q64691 (/IDA) |
Positive regulation of satellite cell activation involved in skeletal muscle regeneration GO:0014718
Any process that activates, maintains or increases the frequency, rate or extent of activation of satellite cell involved in skeletal muscle regeneration. The activation of satellite cell is the process that initiates satellite cell division by causing it to move from quiescence to the G1 stage of the cell cycle. The cell swells and there are a number of other small changes. The cells then start to divide. Following cell division the cells will differentiate.
|
1 | Q64691 (/IDA) |
Response to muscle activity GO:0014850
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle activity stimulus.
|
1 | P16259 (/IDA) |
Regulation of macroautophagy GO:0016241
Any process that modulates the frequency, rate or extent of macroautophagy.
|
1 | P07384 (/NAS) |
BMP signaling pathway involved in spinal cord dorsal/ventral patterning GO:0021919
A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the spatial identity of regions along the dorsal-ventral axis of the spinal cord.
|
1 | Q11002 (/IDA) |
Myofibril assembly GO:0030239
Formation of myofibrils, the repeating units of striated muscle.
|
1 | Q64691 (/IMP) |
Myofibril assembly GO:0030239
Formation of myofibrils, the repeating units of striated muscle.
|
1 | P20807 (/TAS) |
Receptor catabolic process GO:0032801
The chemical reactions and pathways resulting in the breakdown of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
|
1 | O35350 (/IDA) |
Negative regulation of protein sumoylation GO:0033234
Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of SUMO groups to a protein.
|
1 | P20807 (/IDA) |
Negative regulation of protein sumoylation GO:0033234
Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of SUMO groups to a protein.
|
1 | Q64691 (/ISO) |
Cuticle development GO:0042335
The chemical reactions and pathways resulting in the formation of a cuticle, the outer layer of some animals and plants, which acts to prevent water loss.
|
1 | Q11002 (/IDA) |
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
|
1 | P16259 (/IEP) |
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
1 | Q64691 (/ISO) |
Regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122
Any process that modulates I-kappaB kinase/NF-kappaB signaling.
|
1 | Q64691 (/ISO) |
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
|
1 | P07384 (/TAS) |
Sarcomere organization GO:0045214
The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
|
1 | Q64691 (/IMP) |
Regulation of myoblast differentiation GO:0045661
Any process that modulates the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
|
1 | Q64691 (/IDA) |
Positive regulation of proteolysis GO:0045862
Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.
|
1 | Q64691 (/IDA) |
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | Q64691 (/IDA) |
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | Q64691 (/ISO) |
Muscle cell cellular homeostasis GO:0046716
The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state.
|
1 | P20807 (/TAS) |
Defense response to fungus GO:0050832
Reactions triggered in response to the presence of a fungus that act to protect the cell or organism.
|
1 | Q11002 (/IMP) |
Positive regulation of NF-kappaB transcription factor activity GO:0051092
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
|
1 | Q64691 (/ISO) |
Positive regulation of release of sequestered calcium ion into cytosol GO:0051281
Any process that activates or increases the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria.
|
1 | Q64691 (/IMP) |
Regulation of cytoskeleton organization GO:0051493
Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures.
|
1 | P17655 (/TAS) |
Response to calcium ion GO:0051592
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
|
1 | P16259 (/IDA) |
Proteolysis involved in cellular protein catabolic process GO:0051603
The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells.
|
1 | P17655 (/IDA) |
Proteolysis involved in cellular protein catabolic process GO:0051603
The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells.
|
1 | O08529 (/ISO) |
Mammary gland involution GO:0060056
The tissue remodeling that removes differentiated mammary epithelia during weaning.
|
1 | O35350 (/IMP) |
Muscle structure development GO:0061061
The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms.
|
1 | Q64691 (/IMP) |
Cornification GO:0070268
A type of programmed cell death that occurs in the epidermis, morphologically and biochemically distinct from apoptosis. It leads to the formation of corneocytes, i.e. dead keratinocytes containing an amalgam of specific proteins (e.g., keratin, loricrin, SPR and involucrin) and lipids (e.g., fatty acids and ceramides), which are necessary for the function of the cornified skin layer (mechanical resistance, elasticity, water repellence and structural stability).
|
1 | P07384 (/TAS) |
G1 to G0 transition involved in cell differentiation GO:0070315
A cell cycle arrest process that results in arrest during G1 phase, whereupon the cell enters G0 phase, in the context of cell differentiation.
|
1 | Q64691 (/IDA) |
Cellular response to calcium ion GO:0071277
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
|
1 | Q64691 (/IDA) |
Cellular response to salt stress GO:0071472
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
|
1 | Q64691 (/IDA) |
Protein localization to membrane GO:0072657
A process in which a protein is transported to, or maintained in, a specific location in a membrane.
|
1 | Q64691 (/IMP) |
Sodium-dependent self proteolysis GO:1990091
The sodium-dependent hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their own peptide bonds.
|
1 | P16259 (/IDA) |
Negative regulation of skeletal muscle cell differentiation GO:2001015
Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle cell differentiation.
|
1 | Q64691 (/IMP) |
There are 55 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
28 |
B5AFM5 (/ISS)
E2R8T7 (/ISS)
F6RX57 (/ISS)
F6TMZ0 (/ISS)
G1KRC7 (/ISS)
G1MBZ6 (/ISS)
G1QWI5 (/ISS)
G1TSG0 (/ISS)
G3H0X3 (/ISS)
G3TVX4 (/ISS)
(18 more) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
28 |
B5AFM5 (/ISS)
E2R8T7 (/ISS)
F6RX57 (/ISS)
F6TMZ0 (/ISS)
G1KRC7 (/ISS)
G1MBZ6 (/ISS)
G1QWI5 (/ISS)
G1TSG0 (/ISS)
G3H0X3 (/ISS)
G3TVX4 (/ISS)
(18 more) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
24 |
B5AFM5 (/ISS)
E2R8T7 (/ISS)
F6RX57 (/ISS)
F6TMZ0 (/ISS)
G1KRC7 (/ISS)
G1MBZ6 (/ISS)
G1QWI5 (/ISS)
G1TSG0 (/ISS)
G3H0X3 (/ISS)
G3TVX4 (/ISS)
(14 more) |
Myofibril GO:0030016
The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism.
|
21 |
B5AFM5 (/ISS)
E2R8T7 (/ISS)
F6RX57 (/ISS)
F6TMZ0 (/ISS)
G1KRC7 (/ISS)
G1MBZ6 (/ISS)
G1QWI5 (/ISS)
G1TSG0 (/ISS)
G3H0X3 (/ISS)
G3TVX4 (/ISS)
(11 more) |
Z disc GO:0030018
Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.
|
21 |
B5AFM5 (/ISS)
E2R8T7 (/ISS)
F6RX57 (/ISS)
F6TMZ0 (/ISS)
G1KRC7 (/ISS)
G1MBZ6 (/ISS)
G1QWI5 (/ISS)
G1TSG0 (/ISS)
G3H0X3 (/ISS)
G3TVX4 (/ISS)
(11 more) |
T-tubule GO:0030315
Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane.
|
21 |
B5AFM5 (/ISS)
E2R8T7 (/ISS)
F6RX57 (/ISS)
F6TMZ0 (/ISS)
G1KRC7 (/ISS)
G1MBZ6 (/ISS)
G1QWI5 (/ISS)
G1TSG0 (/ISS)
G3H0X3 (/ISS)
G3TVX4 (/ISS)
(11 more) |
Protein complex GO:0043234
A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical.
|
21 |
B5AFM5 (/ISS)
E2R8T7 (/ISS)
F6RX57 (/ISS)
F6TMZ0 (/ISS)
G1KRC7 (/ISS)
G1MBZ6 (/ISS)
G1QWI5 (/ISS)
G1TSG0 (/ISS)
G3H0X3 (/ISS)
G3TVX4 (/ISS)
(11 more) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
20 |
B5AFM5 (/ISS)
E2R8T7 (/ISS)
F6RX57 (/ISS)
F6TMZ0 (/ISS)
G1KRC7 (/ISS)
G1MBZ6 (/ISS)
G1QWI5 (/ISS)
G1TSG0 (/ISS)
G3H0X3 (/ISS)
G3TVX4 (/ISS)
(10 more) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
7 | O08529 (/IDA) P16259 (/IDA) P20807 (/IDA) P35750 (/IDA) Q07009 (/IDA) Q64691 (/IDA) Q9VT65 (/IDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
5 | O08529 (/IDA) O35350 (/IDA) P07384 (/IDA) P17655 (/IDA) Q64691 (/IDA) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
4 | P07384 (/IDA) P16259 (/IDA) P17655 (/IDA) Q64691 (/IDA) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
4 | O08529 (/TAS) O35350 (/TAS) P07384 (/TAS) P17655 (/TAS) |
Dendrite GO:0030425
A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
|
4 | P17655 (/ISS) Q27971 (/ISS) Q92178 (/ISS) Q9GLG1 (/ISS) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
3 | O08529 (/IDA) P16259 (/IDA) P20807 (/IDA) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | Q11002 (/NAS) Q9VT65 (/NAS) |
Lysosome GO:0005764
A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
|
2 | O08529 (/IDA) O35350 (/IDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | O08529 (/ISO) O35350 (/ISO) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | P07384 (/TAS) P17655 (/TAS) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
2 | O08529 (/ISO) O35350 (/ISO) |
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
|
2 | P07384 (/IDA) P17655 (/IDA) |
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
|
2 | O08529 (/ISO) O35350 (/ISO) |
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
2 | P07384 (/IDA) P17655 (/IDA) |
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
2 | O08529 (/ISO) O35350 (/ISO) |
Chromatin GO:0000785
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
|
1 | O08529 (/IDA) |
Acrosomal vesicle GO:0001669
A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome.
|
1 | Q6J756 (/IDA) |
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
|
1 | P07384 (/TAS) |
Intracellular GO:0005622
The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
|
1 | Q11002 (/IDA) |
Intracellular GO:0005622
The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
|
1 | P20807 (/TAS) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q64691 (/ISO) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q64691 (/ISO) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q07009 (/TAS) |
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
1 | O35350 (/IDA) |
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
|
1 | P17655 (/IDA) |
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
|
1 | O08529 (/ISO) |
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
|
1 | P17655 (/IDA) |
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
|
1 | O08529 (/ISO) |
Actin cytoskeleton GO:0015629
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
|
1 | Q11002 (/IDA) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
1 | P07384 (/IDA) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
1 | O35350 (/ISO) |
Myofibril GO:0030016
The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism.
|
1 | P16259 (/IDA) |
Sarcomere GO:0030017
The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
|
1 | P34308 (/IDA) |
Z disc GO:0030018
Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.
|
1 | P16259 (/IDA) |
T-tubule GO:0030315
Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane.
|
1 | P16259 (/IDA) |
Dendrite GO:0030425
A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
|
1 | Q07009 (/IDA) |
Cortical actin cytoskeleton GO:0030864
The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane.
|
1 | P17655 (/TAS) |
Pseudopodium GO:0031143
A temporary protrusion or retractile process of a cell, associated with flowing movements of the protoplasm, and serving for locomotion and feeding.
|
1 | P17655 (/IDA) |
Pseudopodium GO:0031143
A temporary protrusion or retractile process of a cell, associated with flowing movements of the protoplasm, and serving for locomotion and feeding.
|
1 | O08529 (/ISO) |
M band GO:0031430
The midline of aligned thick filaments in a sarcomere; location of specific proteins that link thick filaments. Depending on muscle type the M band consists of different numbers of M lines.
|
1 | P34308 (/IDA) |
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
|
1 | Q11002 (/IDA) |
Protein complex GO:0043234
A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical.
|
1 | Q64691 (/IDA) |
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
|
1 | P17655 (/IDA) |
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
|
1 | O08529 (/ISO) |
Perinuclear endoplasmic reticulum GO:0097038
The portion of endoplasmic reticulum, the intracellular network of tubules and cisternae, that occurs near the nucleus. The lumen of the perinuclear endoplasmic reticulum is contiguous with the nuclear envelope lumen (also called perinuclear space), the region between the inner and outer nuclear membranes.
|
1 | P17655 (/IDA) |
Perinuclear endoplasmic reticulum GO:0097038
The portion of endoplasmic reticulum, the intracellular network of tubules and cisternae, that occurs near the nucleus. The lumen of the perinuclear endoplasmic reticulum is contiguous with the nuclear envelope lumen (also called perinuclear space), the region between the inner and outer nuclear membranes.
|
1 | O08529 (/ISO) |
Ficolin-1-rich granule lumen GO:1904813
Any membrane-enclosed lumen that is part of a ficolin-1-rich granule.
|
1 | P07384 (/TAS) |