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CATH Superfamily 3.90.70.10

Cysteine proteinases

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Cysteine proteinases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 17149: Calpain 2, (M/II) large subunit

There are 5 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Calpain-1. [EC: 3.4.22.52]
Broad endopeptidase specificity.
  • Cytosolic in animal cells.
  • The active enzyme molecule is a heterodimer in which the large subunit contains the peptidase unit, and the small subunit is also a component of EC 3.4.22.53.
  • Belongs to peptidase family C2.
  • Formerly EC 3.4.22.17 and EC 3.4.24.5.
 26 B2ZA85 B2ZA85 E0W233 E0W233 H9G0C4 H9G0C4 O35350 O35350 O42133 O42133
(16 more...)
Calpain-2. [EC: 3.4.22.53]
Broad endopeptidase specificity.
  • Cytosolic in animal cells.
  • The active enzyme molecule is a heterodimer in which the large subunit contains the peptidase unit, and the small subunit is also a component of EC 3.4.22.52.
  • Belongs to peptidase family C2.
  • Formerly EC 3.4.22.17 and EC 3.4.24.5.
 24 A0A061I2B5 A0A061I2B5 A0A061I368 A0A061I368 A6NHC0 A6NHC0 H9EQA5 H9EQA5 O08529 O08529
(14 more...)
Calpain-3. [EC: 3.4.22.54]
Broad endopeptidase activity.
  • Activated by autoproteolytic cleavage of insertion sequence 1 (IS1), which allows substrates and inhibitors gain access to the active site.
  • Substrates include the protein itself and connectin/titin.
  • Belongs to peptidase family C2.
 18 F7G8S2 F7G8S2 P16259 P16259 P20807 P20807 P43368 P43368 P51186 P51186
(8 more...)
4-nitrophenylphosphatase. [EC: 3.1.3.41]
4-nitrophenyl phosphate + H(2)O = 4-nitrophenol + phosphate.
  • A number of other substances, including phenyl phosphate, 4-nitrophenyl sulfate, acetyl phosphate and glycerol phosphate, are not substrates.
 2 A0A170X0R2 A0A170X0R2
Transferred entry: 3.4.22.52 and 3.4.22.53. [EC: 3.4.22.17]
    		2 Q9I8G2 Q9I8G2
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