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CATH Superfamily 3.50.50.60

FAD/NAD(P)-binding domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
FAD/NAD(P)-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 113851: Lysine N6-hydroxylase/L-ornithine N5-oxygenase fam...

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
L-lysine N(6)-monooxygenase (NADPH). [EC: 1.14.13.59]
L-lysine + NADPH + O(2) = N(6)-hydroxy-L-lysine + NADP(+) + H(2)O.
  • The enzyme from strain EN 222 of Escherichia coli is highly specific for L-lysine; L-ornithine and L-homolysine are, for example, not substrates.
 20 A0A099L3U0 A0A099L3U0 A0A0H3KJJ5 A0A0H3KJJ5 B3RAB3 B3RAB3 C5CUE3 C5CUE3 E6V973 E6V973
(10 more...)
L-ornithine N(5)-monooxygenase (NADPH). [EC: 1.14.13.195]
L-ornithine + NADPH + O(2) = N(5)-hydroxy-L-ornithine + NADP(+) + H(2)O.
  • The enzyme is involved in biosynthesis of N(5)-hydroxy-L-ornithine, N(5)-formyl-N(5)-hydroxy-L-ornithine or N(5)-acetyl-N(5)-hydroxy-L- ornithine.
  • These nonproteinogenic amino acids are building blocks of siderophores produced by some bacteria (e.g. Streptomyces coelicolor, Saccharopolyspora erythraea and Pseudomonas aeruginosa).
  • The enzyme is specific for NADPH.
  • Cf. EC 1.14.13.196.
 2 O51940 O51940