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CATH Superfamily 3.50.50.60

FAD/NAD(P)-binding domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
FAD/NAD(P)-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 113557: Nitrite reductase large subunit

There are 6 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Nitrite reductase (NAD(P)H). [EC: 1.7.1.4]
Ammonia + 3 NAD(P)(+) + 2 H(2)O = nitrite + 3 NAD(P)H.
  • The enzymes from the fungi Neurospora crassa, Emericella nidulans and Candida nitratophila and the bacterium Aliivibrio fischeri can use either NADPH or NADH as electron donor.
  • Cf. EC 1.7.1.15.
  • Formerly EC 1.6.6.4.
 396 A0A017I618 A0A023Z403 A0A024KQB8 A0A025CUZ8 A0A026V6V5 A0A027U0P1 A0A028APF1 A0A028EA02 A0A029HHT4 A0A029IIR2
(386 more...)
Transferred entry: 1.7.1.4. [EC: 1.6.6.4]
    		117 A0A024KQB8 A0A026V6V5 A0A027U0P1 A0A028APF1 A0A028EA02 A0A029HHT4 A0A029IIR2 A0A029KA21 A0A029PA80 A0A062Y6T3
    (107 more...)
    Rubredoxin--NAD(+) reductase. [EC: 1.18.1.1]
    2 reduced rubredoxin + NAD(+) + H(+) = 2 oxidized rubredoxin + NADH.
    • The enzyme from Clostridium acetobutylicum reduces rubredoxin, ferricyanide and dichlorophenolindophenol, but not ferredoxin or flavodoxin.
    • The reaction does not occur when NADPH is substituted for NADH.
    • Formerly EC 1.6.7.2.
    		 25 A0A0B6FV23 A0A0E1C7H4 A0A0F0Q6V4 A0A0H3FN88 A0A0H3GYE4 A0A0J2GLJ9 A0A0M1TEZ7 A0A0T7NUU7 A0A0T9L0R0 A0A0T9PC53
    (15 more...)
    Nitrite reductase (NADH). [EC: 1.7.1.15]
    Ammonia + 3 NAD(+) + 2 H(2)O = nitrite + 3 NADH.
    • This prokaryotic enzyme is specific for NADH.
    • In addition to catalyzing the 6-electron reduction of nitrite to ammonia, the enzyme from Escherichia coli can also catalyze the 2-electron reduction of hydroxylamine to ammonia.
    • cf. EC 1.7.1.4.
    		 24 A0A069XPE7 A0A070SP09 A0A0E0U4A8 A0A0E1M6U2 A0A0M7N2Q3 A0A125WY04 A0A140N552 A0A142H7M2 A0A142V3T7 A0A1B1NUU8
    (14 more...)
    Ferredoxin--NAD(+) reductase. [EC: 1.18.1.3]
    Reduced ferredoxin + NAD(+) = oxidized ferredoxin + NADH.
    • The reaction is written for a [2Fe-2S] ferredoxin, which is characteristic of some mono- and dioxygenase systems.
    • some anaerobic bacteria have a 2[4Fe-4S] ferredoxin, which transfers two electrons.
    		 7 A0A0J2HN49 A0A157YWW1 A0A168HKP9 A0A181WHY1 A0A181XAM7 A0A1K3CZ18 V3TY30
    Nitrate reductase (NADH). [EC: 1.7.1.1]
    Nitrite + NAD(+) + H(2)O = nitrate + NADH.
    • Formerly EC 1.6.6.1.
    		 1 A4WBB1