View in Gene3D

CATH Superfamily 3.50.50.60

FAD/NAD(P)-binding domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
FAD/NAD(P)-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 113402: Trypanothione reductase, putative

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Trypanothione-disulfide reductase. [EC: 1.8.1.12]
Trypanothione + NADP(+) = trypanothione disulfide + NADPH.
  • Trypanothione disulfide is the oxidized form of N(1),N(8)- bis(glutathionyl)-spermidine from the insect-parasitic trypanosomatid Crithidia fasciculata.
  • The activity is dependent on a redox-active cystine at the active center (cf. EC 1.8.1.7).
  • Formerly EC 1.6.4.8.
 17 A0A088RI55 A0A1G4I7S0 A4H480 A4HSF7 C6GKV5 D0A4H8 E9AKE1 G0U7X7 P13110 P28593
(7 more...)